Objectives — To estimate the relative risks of albuminuria with all-cause and cardiovascular disease (CVD) mortality in a large cohort of American Indians with diabetes. Methods — A total of 1,953 diabetic participants in the Strong Heart Study were evaluated based on albuminuria categories at baseline examination. The Cox proportional hazards model was used to examine associations. Results — Of the 1,953 participants, 605 (31%) and 410 (21%) had microalbuminuria and macroalbuminuria, respectively, at baseline examination. Microalbuminuria (HR=1.42, 95% CI 1.15—1.77 for all-cause, and HR=1.48, CI 1.01—2.17 for CVD), and macroalbuminuria (HR=3.39, CI 2.71—4.25 for all-cause, and HR=3.74, CI 2.56—5.47 for CVD) were significant predictors for all-cause and CVD mortality after adjustment for other CVD risk factors. Conclusions — Results from the present study suggest that albuminuria is a strong independent predictor of all-cause and CVD Mortality in American Indians with diabetes.
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