Ophthalmoplegia is an unusual finding in diffuse large B cell lymphoma. This report describes the case of a 72-year old male patient who presented with ophthalmoplegia but no gross neurological manifestations and an isolated mass in the left upper thigh. His ophthalmoplegia improved from his first cycle of systemic and intrathecal chemotherapy, his thigh mass effusion spontaneously resolved, and his laboratory tests also showed improvement. The patient remained well, though weak, for several months with no other neurological signs. He subsequently died from clinically diagnosed pulmonary embolism.
ReddyRVVakiliST: Midbrain encephalitis as a remote effect of a malignant neoplasm. Arch Neurol1981; 38: 781–782.
4.
ThirkillCEFitzGeraldPSergottRC: Cancer-associated retinopathy (CAR syndrome) with antibodies reacting with retinal, optic-nerve, and cancer cells. N Engl J Med1989; 321: 1589–1594.
5.
AscasoFJTorresMBerguaJM: Progressive external ophthalmoplegia: A paraneoplastic manifestation of lymphoma. Eur J Ophthalmol2002; 12: 315–318.
6.
LossosAAverbuch-HellerLRechesA: Complete unilateral ophthalmoplegia as the presenting manifestation of Waldenström's macroglobulinemia. Neurology1990; 40: 1801–1802.
7.
TemmelAFPCzernyCSusaniM: Ophthalmoplegia as an unusual initial symptom of non-Hodgkin's lymphoma in the head and neck. Eur Arch Otorhinolaryngol1997; 254: 470–473.
8.
LeeDSWooKIChangHR: T-cell lymphoma presenting as painful ophthalmoplegia. Korean J Ophthalmol2006; 20: 192–194.
9.
YokojiHNakamuraSIkedaT: A case of malignant lymphoma with a metastasis to the lateral rectus muscle. Rinsho Shinkeigaku1997; 37: 526–527.
