Simultaneous treatment with peripheral blood stem-cell (PBSC) transplantation and intensive chemotherapy was evaluated in a case of non-Hodgkin's lymphoma (NHL) with poor prognosis. A 59-year-old male diagnosed with a high-grade, anaplastic large-cell (Ki-1) NHL, involving fractures in the left hip, underwent computed tomography and gallium scintigram surveillance. The patient received chemotherapy with epirubicin hydrochloride, cyclophosphamide, vincristine and prednisolone, and the fractured hip bone was repaired following the first course of chemotherapy. After the second and third courses of chemotherapy, PBSCs were harvested and cryopreserved. The patient then received a further course of chemotherapy and PBSC transplantation was conducted using infused cells consisting of 9.63 × 106/kg CD34 cells and 2.24 × 105/kg granulocyte macrophage colony-forming units. Recovery of platelet and white blood cell counts occurred 10 and 8 days, respectively, after PBSC infusion and the patient remains well.
SteinHMasonDYGerdesJO'ConnorNWainscoatJPallesenG: The expression of the Hodgkin's disease associated antigen KI-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood1985; 66: 848–858
2.
AgnarssonBAKadinME: Ki-1 positive large cell lymphoma: a morphologic and immunologic study of 19 cases. Am J Surg Pathol1988; 12: 264–274
3.
ChottAKasererKAugustinIVeselyMHeinzROehlingerW: Ki-1-positive large cell lymphoma. A clinicopathologic study of 41 cases. Am J Surg Pathol1990; 14: 439–448
4.
TillyHGaulardPLepageEDumontetCDieboldJPlantierI: Primary anaplastic large-cell lymphoma in adults: clinical presentation, immunophenotype, and outcome. Blood1997; 90: 3727–3734
5.
FilippaDALadanyiMWollnerNStrausDJO'BrienJPPortlockC: CD30 (Ki-1)-positive malignant lymphomas: clinical immunophenotypic, histologic, and genetic characteristics and differences with Hodgkin's disease. Blood1996; 87: 2905–2917
6.
LonesMASangerWPerkinsSLMedeirosLJ: Anaplastic large cell lymphoma arising in bone: report of a case of the monomorphic variant with the t(2; 5)(p23; q35) translocation. Arch Pathol Lab Med2000; 124: 1339–1343
7.
NagasakaTNakamuraSMedeirosLJJucoJLaiR: Anaplastic large cell lymphomas presented as bone lesions: a clinicopathologic study of six cases and review of the literature. Mod Pathol2000; 13: 1143–1149
8.
MasonDYBastardCRimokhRDastugueNHuretJLKristofferssonU: CD30-positive large cell lymphomas (Ki-1 lymphoma) are associated with a chromosomal translocation involving 5q35. Br J Haematol1990; 74: 161–168
9.
SarrisAHLuthraRPapadimitracopoulouVWaasdorpMDimopoulosMAMcBrideJA: Amplification of genomic DNA demonstrates the presence of the t(2; 5) (p23; q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. Blood1996; 88: 1771–1779
10.
SchwabUSteinHGerdesJLemkeHKirchnerHSchaadtMDiehlV: Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature1982; 299: 65–67
11.
FaninRSilvestriFGerominACernoMInfantiLZajaF: Primary systemic CD30 (Ki-1)- positive anaplastic large cell lymphoma of the adult: sequential intensive treatment with the F-MACHOP regimen (+/– radiotherapy) and autologous bone marrow transplantation. Blood1996; 87: 1243–1248
12.
FaninRSperottoASilvestriFCernoMGerominAStocchiR: The therapy of primary adult systemic CD30-positive anaplastic large cell lymphoma: results of 40 cases treated in a single center. Leuk Lymphoma1999; 35: 159–169
13.
HarrisNLJaffeESSteinHBanksPMChanJKClearyML: A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood1994; 84: 1361–1392
14.
FossHDDemelGAnagnostopoulosIAraujoIHummelMSteinH: Uniform expression of cytotoxic molecules in anaplastic large cell lymphoma of null/T cell phenotype and in cell lines derived from anaplastic large cell lymphoma. Pathobiology1997; 65: 83–90
15.
KrenacsLWellmannASorbaraLHimmelmannAWBadgiEJaffeESRaffeldM: Cytotoxic cell antigen expression in anaplastic large cell lymphomas of T- and null-cell Type and Hodgkin's disease: evidence for distinct cellular origin. Blood1997; 89: 980–989
16.
DukersDFten BergeRLOudejansJJPulfordKHayesDMisereJF: A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas. J Clin Pathol1999; 52: 129–136
17.
FragaMBroussetPSchlaiferDPayenCRobertARubieH: Bone marrow involvement in anaplastic large cell lymphoma; immunohistochemical detection of minimal disease and its prognostic significance. Am J Clin Pathol1995; 103: 82–89
18.
DeconinckELamyTFoussardCGaillardFDelwailVColombatP: Autologous stem cell transplantation for anaplastic large-cell lymphomas: results of a prospective trial. Br J Haematol2000; 109: 736–742
