Research has led to effective treatment regimes for erectile dysfunction (ED). Convincing evidence links vascular risk factors (hypertension, diabetes mellitus, hyperlipidaemia and smoking) with ED. This association is not surprising since the corpus cavernosum is a modified vascular tissue. This review presents a brief account of the aetiology, diagnosis and treatment of ED. There is a need to raise awareness of this condition and to make appropriate treatment available to patients.
NIH Consensus Conference . Impotence. NIH Consensus Development Panel on Impotence . JAMA1993;270: 83-90
2.
Benet AE , Melman A.The epidemiology of erectile dysfunction . Urol Clin North Am1995;22(4): 699-709
3.
Rosen R , Fisher W , Eardley I , Niederberger C , Nadal A , Sand M.The Multinational Men’s Attitudes to Life Events and Sexuality (MALES) Study I. Prevalence of erectile dysfunction and related health concerns in the general population . Curr Med Res Opin2004;20(5): 607-617
Sullivan ME , Thompson CS , Dashwood MR , Khan MA , Jeremy JY , Morgan RJ , et al.Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease?Cardiovasc Res1999;43(3): 658-665
6.
Hedon F.Anxiety and erectile dysfunction: a global approach to ED enhances results and quality of life . Int J Impot Res2003;15(Suppl) 2: S16-S19
7.
Kantor J , Bilker WB , Glasser DB , Margolis DJ.Prevalence of erectile dysfunction and active depression: an analytic cross-sectional study of general medical patients . Am J Epidemiol2002;156(11): 1035-1042
8.
Kirby R , Carson C , Goldstein I.Erectile Dysfunction: A Clinical Guide. Oxford: Isis Medical Media , 1999
9.
O’Keefe M , Hunt DK.Assessment and treatment of impotence . Med Clin North Am1995;79(2): 415-434
10.
Slag MF , Morley JE , Elson MK , Trence DL , Nelson CJ , Nelson AE , et al.Impotence in medical clinic outpatients . JAMA1983;249(13): 1736-1740
11.
Rosen R , Altwein J , Boyle P , Kirby RS , Lukacs B , Meuleman E , et al.Lower urinary tract symptoms and male sexual dysfunction: the multinational survey of the aging male (MSAM-7) . Eur Urol2003;44(6): 637-649
12.
Shabbir M , Mikhailidis DP , Morgan RJ.Erectile dysfunction: an underdiagnosed condition associated with multiple risk factors . Curr Med Res Opin2004;20(5): 603-606
13.
Hall SJ , Basile G , Bertero EB , de las Morenas A , Goldstein I.Extensive corporeal fibrosis after penile irradiation . J Urol1995;153(2): 372-377
14.
Foresta C , Caretta N , Garolla A , Rossato M.Erectile function in elderly: role of androgens . J Endocrinol Invest2003;26(3 Suppl): 77-81
15.
Rosen RC , Cappelleri JC , Gendrano N 3rd . The International Index of Erectile Function (IIEF): a state-of-the-science review . Int J Impot Res2002;14(4): 226-244
16.
Carter HB , Epstein JL , Walsh PC , Parton AW.Age, PSA and the chance of curable prostate cancer among men with non-palpable disease . J Urol1998;159: 74
17.
Citron JT , Ettinger B , Rubinoff H , Ettinger VM , Minkoff J , Hom F , et al.Prevalence of hypothalamic-pituitary imaging abnormalities in impotent men with secondary hypogonadism . J Urol1996;155(2): 529-533
18.
Zonszein J.Diagnosis and management of endocrine disorders of erectile dysfunction . Urol Clin North Am1995;22(4): 789-802
19.
Khan MA , Morgan RJ , Mikhailidis DP.The choice of antihypertensive drugs in patients with erectile dysfunction . Curr Med Res Opin2002;18(2): 103-107
20.
The treatment of mild hypertension study . A randomized, placebo-controlled, trial of a nutritional-hygienic regimen along with various drug monotherapies . Arch Intern Med1991;151(7): 1413-1423
21.
Aversa A , Isidori AM , Spera G , Lenzi A , Fabbri A.Androgens improve cavernous vasodilation and response to sildenafil in patients with erec-tile dysfunction . Clin Endocrinol2003;58(5): 632-638
22.
Guay AT , Perez JB , Velasquez E , Newton RA , Jacobson JP.Clinical experience with intraurethral alprostadil (MUSE) in the treatment of men with erectile dysfunction. A retrospective study. Medicated urethral system for erection . Eur Urol2000;38(6): 671-676
23.
Khan MA , Raistrick M , Mikhailidis DP , Morgan RJ.MUSE: clinical experience . Curr Med Res Opin2002;18(2): 64-67
24.
Montorsi F , Salonia A, Deho’ F , Cestari A , Guazzoni G , Rigatti P , et al.Pharmacological management of erectile dysfunction . BJU Int2003;91(5): 446-454
25.
Erratum in: N Engl J Med1998;339(1): 59
26.
Khan MA , Mikhailidis DP , Morgan RJ.Sildenafil: a urologist’s view . Curr Med Res Opin2000;16(Supp1): S48-S58
27.
Francis SH , Corbin JD.Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists . Curr Urol Rep2003;4(6): 457-465
28.
Crowe SM , Streetman DS.Vardenafil treatment for erectile dysfunction . Ann Pharmacother2004;38(1): 77-85
29.
Keating GM , Scott LJ.Spotlight on vardenafil in erectile dysfunction . Drugs Aging2004;21(2): 135-140
30.
Porst H.The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience . J Urol1996;155(3): 802-815
31.
Bella AJ , Brock GB.Tadalafil in the treatment of erectile dysfunction . Curr Urol Rep2003;4(6): 472-478
32.
Zorgniotti AW.Experience with buccal phentolamine mesylate for impotence . Int J Impot Res1994;6(1): 37-41
33.
Morales A , Heaton JP , Johnston B , Adams M.Oral and topical treatment of erectile dysfunction. Present and future . Urol Clin North Am1995;22(4): 879-886
34.
Duncan BL , Parkes MB.Integrating individual and systems approaches: strategic-behavioural therapy . J Marital Fam Ther1988;1: 151-161
35.
Hiller J.Psychoanalytic concepts and psychosexual therapy . Sexual Marital Therapy1993;8: 9-26
36.
Spence SH.Psychosexual Therapy: A Cognitive-Behavioural Approach. London: Chapman and Hall , 1991
37.
Aloui R , Iwaz J , Kokkidis MJ , Lavoisier P.A new vacuum device as alternative treatment for impotence . Br J Urol1992;70(6): 652-655
38.
Lewis RW , Witherington R.External vacuum therapy for erectile dysfunction: use and results . World J Urol1997;15(1): 78-82
39.
Lewis RW . Intraurethral and topical agents . Drugs Today2000;36(2-3): 113-119
40.
Stackl W , Hasun R , Marberger M.Intracavernous injection of prostaglandin E1 in impotent men . J Urol1988;140(1): 66-68
41.
Sundaram CP , Thomas W , Pryor LE , Sidi AA , Billups K , Pryor JL.Long-term follow-up of patients receiving injection therapy for erectile dysfunction . Urology1997;49(6): 932-935
42.
Anastasiadis AG , Wilson SK , Burchardt M , Shabsigh R.Long-term outcomes of inflatable penile implants: reliability, patient satisfaction and complication management . Curr Opin Urol2001;11(6): 619-623
