Effects of telerehabilitation monitored home-based therapies on upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy: A systematic review

Abstract

Introduction:

Children and adolescents with cerebral palsy (CP) demonstrate proficient function if they can perform all tasks required for daily living. Telerehabilitation (TR) and monitoring can facilitate the execution of home-based (HB) therapies. This systematic review aimed to assess the scientific evidence regarding the effects of TR-monitored HB therapies on outcomes related to upper extremity function in children and adolescents with unilateral cerebral palsy (UCP).

Methods

Comprehensive searches were conducted across online databases, including the Cochrane Library, EMBASE, PubMed, Web of Science, and PEDro, as well as additional sources, from inception to October 2025. The inclusion criteria encompassed randomized controlled trials, whose risk of bias and methodological quality were evaluated using the Cochrane Risk-of-Bias Tool and the PEDro scale, respectively. A narrative synthesis approach was employed for data analysis.

Results

TR-monitored HB therapies showed positive improvements in hand coordination, dexterity, bimanual hand function, ADL motor and processing skills, occupational performance, and execution of functional goals in children and adolescents with UCP (predominantly spastic UCP studies) compared with the control interventions.

Conclusions

Telerehabilitation-monitored HB therapies showed potential to improve upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy (predominantly spastic UCP studies).

Keywords

Telerehabilitation home-based therapies upper extremity function cerebral palsy children adolescents systematic review

Introduction

Spastic hemiparetic cerebral palsy (CP) primarily occurs due to unilateral injury to the motor cortex and/or pyramidal tract, causing hypertonia in certain antagonist muscles contralateral to the injury.¹ Unilateral spastic CP occurs due to damage to one brain hemisphere, causing functional impairments with spasticity in the flexor muscles, range of motion limitations, and low muscular strength.² Diminished upper extremity (UE) movements due to spasticity, weakness, and lack of selective muscle activation affect numerous children with CP, and these impairments with sensory deficits restrict synchronized and smooth movements needed for activities of daily living (ADL).³ Upper extremity impairments impair function and restrict motor independence in ADL.⁴ Sensory and motor impairments contribute to the functional limitations of the affected UE in children with unilateral spastic CP, with unimanual ability determined by these limitations and impaired unimanual ability affecting bimanual performance.²

Traditionally, UE management focused on decreasing motor impairments and enhancing the quality of movement in children with unilateral CP.⁵ Throughout the years, the model has transformed from an isolated therapy for impairments, such as spasticity and strength, to methods focusing on enhancing ADL and motor function.⁶ Recent advances in computer technology have enabled the online administration and monitoring of training, permitting therapist-participant interaction, which gives participants the feeling of having a personal instructor.⁷ Technological developments provide an option to paper-based home programs in the form of applications and websites for online exercise prescription.⁸

Numerous healthcare professionals widely utilize telerehabilitation as part of a multidisciplinary team.⁹ Telerehabilitation is defined as the use of information and communication technologies to deliver rehabilitation services.¹⁰ Despite its importance, complying with exercise is difficult as individuals are unable to attend a gym or clinic for exercise; thus, studies on tele-exercise interventions using direct or indirect supervision have produced results comparable to in-person, clinic-based interventions.¹¹ Physical exercise can be conducted in different settings, such as gyms, rehabilitation centers, home, or public parks.¹² Under conditions of impaired mobility that might hamper participation in exercise programs, individuals may perform the exercise at home.¹¹ Moreover, teaching exercises at home may be easier, as it provides an opportunity to establish where the exercise can be safely performed with resultant higher confidence and thus more demanding exercise.¹³

Given the aforementioned context and to the best of our knowledge, no systematic review has examined the effects of TR-monitored HB therapies on UE function-related outcomes in children and adolescents with UCP. Therefore, this systematic review aimed to assess the scientific evidence regarding the effects of TR-monitored HB therapies on UE function-related outcomes in this population.

Methodology

This review has the PROSPERO Registration number CRD420251045310. The review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The PICOS framework was applied to develop the research question: what are the effects of TR-monitored HB therapies (I = intervention) on UE function (O = outcome) in children and adolescents with UCP (P = population) compared with standard, conventional, usual, or other therapies (C = comparison) in randomized controlled trials (RCTs) (S = study design)? The search procedure, appraisal of methodological quality, study selection, evaluation of risk of bias, and data extraction were conducted as outlined in our previous reviews,^14–16 with adjustments to the databases searched, the dates of the searches, the search strategy, the selection criteria, and the data extracted to align with the objectives of this review.

Search strategy

Comprehensive searches were performed across online databases, including the Cochrane Library, EMBASE, PubMed, Web of Science, and PEDro, covering the period from their inception until October 2025. Utilizing the PICOS framework, the search methodology was designed to align with the specific requirements of each database. Detailed information on the search methodology is provided in Supplementary Material 1. A comprehensive manual literature search was conducted, encompassing searches through various search engines, citation searches and cross-referencing. This included examining the reference lists of the identified studies and employing forward citation tracking. Following the export of the identified studies to Endnote Reference Manager and the subsequent removal of duplicates, the remaining studies underwent additional screening. The search was independently conducted by one author (JSU) and subsequently validated by the other two authors (TWLW and SSMN).

Selection criteria

The review involved studies that met the following inclusion criteria: studies (i) involving children and adolescents with unilateral/hemiplegic CP (UCP), (ii) describing the effects of TR-monitored HB therapies, including HB therapies with remote components such as telephone support/follow-up (iii) conducted in humans and published in peer-reviewed journals in English, and (iv) with an RCT design and accessible full text. The exclusion criteria were as follows: ❖

Abstracts of theses, conference papers, review studies, and unpublished works.

❖

Studies involving interventions administered solely in clinical or hospital environments.

❖

Studies without any telerehabilitation component, such as the use of technology, remote/tele monitoring/supervision, remote/tele coaching, remote/tele support, remote feedback, or telecommunication.

❖

Studies that included a mixed population (cerebral palsy and other conditions) without separate data on the cerebral palsy population.

Eligibility assessment and data abstraction

After duplicate records were eliminated, two authors (JSU and TWLW) independently evaluated the titles and abstracts of the studies. During the screening process, the review eligibility criteria were applied, and any disagreements between the two authors regarding the inclusion of a study were resolved through consultation with a third author (SSMN). In the course of the full-text screening phase, the complete texts of studies deemed eligible were retained, and the following pertinent information was systematically extracted from these studies: author, year of publication, design, sample size, sex and age, types of UCP, population, clinical characteristics of the population, intervention(s) groups and treatment protocol, telerehabilitation components involved, type of technology involved, details of monitoring/delivery, outcomes, assessment period, adverse events, results, and conclusions. The extracted data and characteristics of the eligible studies were entered into a Microsoft Excel spreadsheet.

Methodological quality appraisal and evaluation risk of bias

The methodological quality (MQ) of the eligible studies was assessed using the PEDro scale. The scale comprise of 11-itmes designed to evaluate the MQ of the studies.¹⁷ The 11 items encompass the internal validity of the study and statistical reporting. Notably, the first item on the eligibility criteria was excluded from the computation of the overall score.¹⁸ Each of the ten internal validity items was assigned a score of 1 or 0, indicating the presence or absence of the item.¹⁸ The overall score was categorized into four quality levels: excellent (9–10), good (6–8), fair (4–5), and poor (0–3).^19,20

The Cochrane ROB tool was utilised to determine the risk of bias (ROB) in the eligible studies. Three evaluative decisions categorized as unclear, high, or low were applied to evaluate the ROB for particular items across the domains of attrition, reporting, performance, blinding, selection, detection, and other biases.²¹ Two authors (JSU and TWLW) independently performed these assessments. Any discrepancies were addressed by seeking input from the third author (SSMN).

Synthesis and analysis

The extracted data were analysed using narrative synthesis. The risk of bias (ROB), methodological quality (MQ), findings, and characteristics of the eligible studies were summarized descriptively.

Results

Study selection

A total of 420 pertinent records were retrieved from the databases and additional source searches. After removing 76 duplicate records, 344 records remained. A total of 292 records were disqualified for failing to meet the eligibility requirements in the course of title and abstract screening. Subsequently, the full texts of the remaining 52 reports were retrieved and evaluated in accordance with the review eligibility criteria. The review involved nine studies comprising ten reports. All included studies were RCTs employing a parallel design. Figure 1 presents the methodology for study selection, guided by PRISMA guidelines.

Figure 1.

PRISMA 2020 flowchart

MQ assessment

All of the included studies had a good MQ. In all studies included in the analysis of the PEDro scale domains, the following elements were consistently present: specification of eligibility criteria, random allocation, baseline similarity among groups concerning key prognostic indicators, absence of experimenter blinding, and description of between-group comparisons. The majority of the studies demonstrated allocation concealment, lacked participant blinding, included outcome assessor blinding, measured main outcomes for most participants originally allocated to groups, ensured that all subjects for whom outcome measures were available received the treatment or control condition as allocated, and provided point measures and measures of variability for main outcomes. Table 1 presents a detailed account of the methodological quality of the studies.

Table 1.

Methodological quality of the included studies according PEDro criteria.

Author (year)	Item 1	Item 2	Item 3	Item 4	Item 5	Item 6	Item 7	Item 8	Item 9	Item 10	Item 11	Total score	Overall quality assessment
Beani (2020)	Yes	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Yes	Yes	8	Good quality
Beani (2023)	Yes	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Yes	Yes	8	Good quality
Chiu (2014)	Yes	Yes	No	Yes	No	No	Yes	Yes	Yes	Yes	Yes	7	Good quality
Comans (2017)	Yes	Yes	No	Yes	No	No	No	Yes	Yes	Yes	Yes	6	Good quality
Ejaz (2024)	Yes	Yes	No	Yes	Yes	No	No	Yes	Yes	Yes	No	6	Good quality
Ferre (2016)	Yes	Yes	Yes	Yes	No	No	Yes	No	Yes	Yes	Yes	7	Good quality
Hwang (2025)	Yes	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Yes	Yes	8	Good quality
James (2015)	Yes	Yes	Yes	Yes	No	No	No	Yes	Yes	Yes	Yes	7	Good quality
Kirkpatrick (2016)	Yes	Yes	Yes	Yes	No	No	Yes	No	No	Yes	Yes	6	Good quality
Rezk (2022)	Yes	Yes	Yes	Yes	No	No	No	Yes	Yes	Yes	Yes	7	Good quality

Item 1: eligibility criteria specified; Item 2: subjects were randomly allocated to groups(in a crossover study, subjects were randomly allocated an order in which treatments were received); Item 3: Allocation was concealed; Item 4: the groups were similar at baseline regarding the most important prognostic indicators; Item 5: there was blinding of all subjects; Item 6: there was blinding of all therapists who administered the therapy; Item 7: there was blinding of all assessors who measured at least one key outcome; Item 8: Measures of at least one key outcome were obtained from more than 85% of the subjects initially allocated to groups; Item 9: all subjects for whom outcome measures were available received the treatment or control condition as allocated or, where this was not the case, data for at least one key outcome was analyzed by “intention to treat”; Item 10: the results of between-group statistical comparisons are reported for at least one key outcome; Item 11: The study provides both point measures and measures of variability for at least one key outcome.

ROB assessment

All studies exhibited a low risk of bias (ROB) in other bias, reporting bias, and attrition bias domains. Most studies demonstrated a low ROB for allocation concealment (selection bias), random sequence generation (selection bias), and detection bias. However, nearly all studies showed a high ROB in performance bias. Figures 2A and 2B present detailed information on the ROB in the included studies.

Figure 2.

A. Risk of bias graph. B. Risk of bias summary.

Study characteristics

In total, 481 children and adolescents with UCP participated in the included studies, with an overall mean age ranging from 4.83 to 12.1 years. All studies used a parallel RCT design. Seven studies reported the affected side,^22–28 and three reported GMFCS levels.^23,24,26 Five studies reported MACS.^{23,24,26,28,29} However, HFCS has been reported in a few studies. In the majority of the studies, the participants were children and adolescents with spastic UCP (seven out of nine studies explicitly stated this, while one study implied it), and one study did not specify the type of UCP involved. UCP and home-based therapies/training were reported in all the studies. In terms of the types of therapies/training, one study each administered Wii Sports Resort™ training²⁶ and modified constraint-induced movement therapy.³⁰ Two studies applied a web-based multimodal therapy program (Mitii^TM therapy),^23,29 while three reports each used action observation training (AOT)^22,25,27 and bimanual training/therapy.^24,28,31 The studies described various telerehabilitation components, technologies, and monitoring methods used. Regarding outcome assessment, all included studies conducted before and after intervention outcome assessments, with some including follow-up assessments. Information regarding adverse events associated with the studies was also reported. Table 2 presents the detailed characteristics of the included studies.

Table 2.

Characteristics of included studies.

Author (year)Design	NSexAge(Y)	Types of UCP Population	Clinical characteristics of the patient population Type of therapy	Intervention(s)/groups Treatment protocol	TR components involvedType of technology involvedDetails of monitoring/delivery	Outcomes Assessment periodAdverse events	Results	Conclusions
Beani (2020) RCT-P	29 15M, 14F 11.73 ± 3.65	Spastic motor type of UCP Children and adolescents	Affected side: R: 19, L: 10 HFCS: grade 2–3: 5, grade 4–5: 13; grade 6–8: 11 AOT (using Tele-UPCAT)	EG: HB-AOT using Tele-UPCAT system CG: Usual care involving UL training Participants performed 15 sessions of HB-AOT for 45–60 min per day for 3 weeks (5 days per week)	TR/TM Tele-monitored Upper Limb children action observation training (Tele-UPCAT) using Tele-UPCAT system Weekly telephone-based contact between research team member with the participants and their parents	Questionnaire on usability and acceptability. Acceptability assessed with actigraphs. Pre and post Adolescents reported itchiness and being bothered due to the actigraph wristbands and experienced pain and discomfort from the frequency of required movements.	Tele-UPCAT platform was established to be usable and acceptable for HB-training	HB-AOT is feasible for adolescents and children with UCP
Beani (2023) RCT-P	30 16 M, 14F 11.61 ± 3.55	Spastic UCP Children and adolescents	Affected side: R: 10, L: 20 HFCS level: ≥2 Cognitive level: IQ ≥ 70 (within or at normal limits) AOT (using Tele-UPCAT)	EG: Intensive HB-AOT delivered with a customized ICT platform (Tele-UPCAT system) CG: SC (UC) involving physical/occupational therapy Over the course of 3 weeks, participants engaged in HB-AOT for 15 sessions, conducted 5 times a week, each lasting around 1 h.	TM Tel-UPCAT platform using all in one computer with software, toys, and a pair of actigraphs. Parents and caregivers are guided/coached by therapists to implement the training at home. To facilitate the monitoring of additional therapies potentially administered during the study period, all participating families were required to maintain a diary documenting the details of their daily routines.	Hand use in bimanual activities, quality of UE movement/unimanual capacity, gross manual dexterity, manual ability/hand function in activities of daily living, home participation, and quality of life. Baseline and post intervention. No adverse events detection	The intensive in-home AOT group demonstrated significant improvement versus SC on the AHA, sustained at 6 months. The AOT group demonstrated significantly larger improvements in BBT of the less affected hand. No significant differences were found for affected hand BBT or MA2. The tele-upcat platform showed good feasibility and adherence	The study shows that AOT home training via the ICT platform enhances UL goal-directed skills in children with Unilateral CP, with effects persisting for 6 months. This technology enables effective home training in childhood.
Chiu (2014) RCT-P	62 28M EG: 9.4 ± 1.9 CG: 9.5 ± 1.9	Spastic hemiplegic CP Children	Affected side: R:31 GMFCS: Level I-III: 52; Level IV-V:10 MACS: level I-III: 42; Level IV-V:20 Wii Sports Resort™ training	EG: HB-Wii Sports Resort™ training + usual therapy CG: Usual therapy The intervention was given three times a week for 6 weeks, each session lasts 40 min.	Supervision by the therapist and remote monitoring/support via follow-up telephone calls, if necessary. Virtual reality training at home (exergaming) uses Nintendo Wii Sports Resort games with the Wii remote held in the affected hand. Therapist supervised a session per week and was available for follow-up phone calls when necessary. Parents/carers supervised the other two sessions.	Coordination, strength, hand function, and carers’ perception of hand function. Baseline, 6 weeks (post intervention), and 12 weeks (6 weeks follow-up) Not specified in the study	At 6 and 12 weeks, the Wii group showed no significant differences compared to the controls in coordination or HF tests. However, GS showed improvement trends in the EG compared to the CG. By week 12, the CGs reported a significantly higher quantity of HF perception (p = 0.03) in the EG, persisting post-intervention. HB training compliance was 96%.	Wii training showed no improvements in coordination, strength, or HF, but motivated children to use affected hands more in daily activities, as CGs observed. This provides an engaging method for home exercise.
Comans (2017) RCT-P	102 52 M, 50F Children: 9.9 ± 1.3 Adolescents: 14.3 ± 1.3	Spastic unilateral CP Children and adolescents	MACS: level 1: 11, level 2:39, level 3: 1 Web-based multimodal therapy programme [‘Move it to improve it’ (Mitii^TM)]	EG: Mitii training (HB-web based programme) CG: Usual care The intervention duration was for 20 weeks per participant.	RM Internet-connected computer with webcam Staff time was recorded using electronic logs, encompassing the review and modification of exercise programs, as well as communication with participants and their caregivers via emails and Skype calls.	Motor and Process Skills. Occupational performance Baseline and at 20 weeks Not reported in the study	HB web-based system led to significantly more responders on both the AMPS and COPM functional measures compared to usual care.	The Mitii web-based rehabilitation system represents good value for money for children with mild to moderate UL CP.
Ejaz (2024) RCT-P	40 17 M, 23F GA:4.80 ± 0.69 GB: 4.85 ± 0.81	Unilateral spastic CP Children	NR Hand-arm bimanual intensive therapy (HABIT)	GA: HB Standard physical treatment GB: HB Bimanual training along with routine physical therapy HB task- and goal-specific bimanual training for 3 h per week for 6 weeks.	Tele-coaching/remote coaching Virtual guidance and video documentation In-person visits by the training staff, tele-coaching, and video recordings.	Daily activities/ADL and hand coordination, manual ability Baseline, 4th week and 6th week Not reported in the study	There was a significant difference in hand coordination from baseline to 6th week of intervention in group B, but not in group A.	There were significant attainments in activities of daily living and hand coordination with application of combined impact of HB bimanual exercise and routine physical therapy
Ferre (2016) RCT-P	24 10M, 14F EG: 5.2 ± 2.7 CG: 5.8 ± 2.3	Unilateral spastic CP Children	Affected side: R: 14, L: 12 GMFCS: Level 1: 20; Level 2: 6 MACS: level 1: 3, level 2 Hand-arm bimanual intensive therapy (HABIT)	EG: HB hand-arm bimanual intensive therapy (HB-HABIT) CG: LL functional intensive training (LIFT-control) The training was for 2 h per day, any 5 days per week, for 9 weeks.	TR/RS Webcam-based software (Adobe Connect). Participants were monitored through Adobe Connect webcam-based software while engaging in activities at home. Weekly supervision consisted of 1 h for 9 weeks, with a supervisor monitoring training through online submitted logs.	Dexterity, unimanual and bimanual hand function, bimanual performance, caregiver-rated functional goals Pre, post and 6 months follow-up Not reported in the study	HB-HABIT enhanced dexterity and execution of functional goals.	HB models offer a valuable, family-focused method to attain increased intensity of treatment.
Hwang (2025) RCT-P	22 12 M, 10F 5.48 ± 1.34	UnilateralCP Children	Affected side: R: 17, L: 5 MACS: level 1: 7, level 2:10, level 3: 5 Hand-arm bimanual intensive therapy (HABIT)	EG: HB HABIT (H-HABIT) + mCIMT CG:mCIMT In phase 1, both groups underwent mCIMT for a total of 30 h over 3 weeks. In phase 2, The H-HABIT program was delivered via TR for 30 h, comprising fifteen 2-h sessions conducted thrice weekly over 5 weeks to the EG only.	TR/RM The technology involved includes Zoom for video conferencing and smartphones for remote monitoring by OT. A TR method that utilized video conferencing to conduct H-HABIT sessions live. Caregiver logs were also used.	Hand use in bimanual activities, how often/how well is the use of affected arm in daily activities, overall functional independence, quality of UE movement, and physical activity Baseline, post -mCIMT (3 weeks), and post-H-HABIT (5 weeks later). Although adverse events were monitored during the sessions, none were specifically reported.	The EG showed a significant time × group interaction for AHA scores, suggesting that H-HABIT contributed to sustained progress throughout. However, improvements post-H-HABIT did not exceed the smallest detectable difference. H-HABIT gains did not translate to significant changes in the real-world arm use. TR H-HABIT received positive caregiver ratings (83.33%: easy to follow guidelines, 91.67%: helpful therapist interactions).	The 30-h H-HABIT regimen after mCIMT shows potentialfor maintaining benefits and reducing regression. While TR proved feasible and well-received by families, improvements did not significantly translate into gains in real world daily activities or actigraphy measures.
James (2015) RCT-P	101 51 M, 50F EG: 11.8 ± 2.4 CG: 11.10 ± 2.5	Spastic unilateral CP Children	Affected side: R: 53, L: 48 GMFCS: Level I: 45; Level II: 56 MACS: level 1: 24, level II: 76, level III: 1 Web-based multimodal therapy programme [‘Move it to improve it’ (Mitii^TM)]	EG: HB Mitii therapy CG: Standard care/Usual care Mitii was for 20 to 30 min, 6 days a week for 20 weeks.	RM/RS Web-based multimodal therapy programme. The program functions on a cloud server platform utilizing Adobe Flash technology and can be accessed through a computer with an internet connection. Therapists remotely monitored the participants’ programs, adjusting modules weekly by enhancing speed, accuracy, and complexity. They maintained communication to provide feedback and support through weekly emails and biweekly telephone and/or Skype calls. Participants tracked progress over 20 weeks using a rewards chart (online supporting information).	ADL Motor and process skills, bimanual function, hand function (unimanual speed and dexterity), upper limb function, self-perceived occupational performance, and visual perception. Baseline and 20 weeks During the intervention period, one participant experienced seizures, although the parents reported that this was unrelated to Mitii.	Mitii results in significant improvements in occupational performance goal attainment, visual processing, and ADL motor and processing skills. No between-groups differences on measures of impaired UE function.	Mitii provides a multimodal therapy which is web-based that can greatly increase the dose of therapy received by children with CP.
Kirkpatrick (2016) RCT-P	70 31F 5.6 ± 2.1	Unilateral CP (spastic type implied) Children	Affected side: L:40 Action observation therapy (AOT)	EG: HB AOT + repeated practice CG: Repeated practice The intervention spanned 3 months. Parents were instructed to conduct five sessions each week, with each session lasting15 min.	RS Parents were given a therapy diary to record the details of the sessions, along with reward stickers for their children. To improve adherence and ensure that the treatment was followed correctly, families received supportive phone calls every 2 weeks.	Spontaneous use of the affected hand in bimanual activities, unimanual capacity/ quality of UE movement and hand function in activities of daily living/manual ability Baseline, at 3 months and at 6 months No adverse events were associated with either treatment or assessment.	No significant differences were observed between the AO + RP and RP alone groups for AHA, MA2, or ABILHAND-Kids at 3 and 6 months. The combined-group showed significant improvements in AHA and MA2 at 3 months, which were sustained at 6 months. AHA improvement was below the smallest detectable difference. Most participants (78%) achieved over 1-h weekly therapy.	In home-based, parent-delivered play therapy, AO + RP showed no greater efficacy than RP alone. However, a parent-delivered home program of play therapy for 1 h weekly yields modest, lasting improvement in upper limb function.
Rezk (2022) RCT-P	30 17 M, 13F EG: 6.23 ± 0.78 CG: 6.17 ± 0.68	Spastic hemiplegic CP Children	NS Modified constraint induced movement therapy (mCIMT)	EG: Telerehabilitation using mCIMT with selected play-based exercises + mCIMT during home activities CG: mCIMT during home activities The EG participated in TR sessions with mCIMT and play-based exercises for 90 min, thrice weekly, plus mCIMT during home activities four times weekly for 8 weeks. The CG participated in mCIMT for 90 min daily, integrated into their regular home activities.	TR Zoom video call application (smart phone, tablet, computer or laptop, and good internet connection). Sessions were conducted via Zoom with live therapist demonstration. During the calls, the therapist demonstrated exercises and techniques to the parents and children, providing guidance. The therapist recorded every exercise session on an evaluation sheet for each child.	Quality of UE movement patterns and hand function Baseline and post-treatment Not reported in the study	Both the TR and Control groups demonstrated significant improvements in the QUEST total score and subscales of DM, grasp, WB, and PR after the intervention. The TR group achieved superior improvements across all QUEST subscales and total score compared to the CG. Parents reported high satisfaction with TR sessions and willingness to use TR again. Post-intervention, TR group showed significant differences compared to CG across all QUEST subscales and total score	Tele-rehabilitation using HB mCIMT is an effective treatment for improving upper limb function in children with hemiplegic CP. It can serve as a valuable home-based rehabilitation method during the spread of epidemics and as an effective alternative to in-person rehabilitation. Its success stems from therapist and parent supervision during sessions, emphasizing functional tasks through repetition and complexity.

AMPS: Assessment of Motor and Process Skills; COPM: Canadian Occupational Performance Measure; Mean ± SD: Mean ± standard deviation; RCT-P: parallel randomized controlled trial; Y: years; N: total sample size; M: male; F: female; SD: standard deviation; CP: cerebral palsy; R: right; L: left; HB: home-based; EG: experimental group; CG: control group; UL: upper limb; UCP: unilateral cerebral palsy; AOT: Action Observation Training; UPCAT: Upper Limb Children Action Observation Training; HFCS: House Functional Classification System; CP: cerebral palsy; MACS: Manual Ability Classification Scale; Mitii: ‘Move it to improve it’; NR: not reported; G: group; ADL: activities of daily living; PAM: pathological ameliorative model; TDM: typically developed individual/model; GMFCS: gross motor function classification system; KHC: kinematic manipulation pattern; UE: upper extremity; HABIT: hand-arm bimanual intensive therapy; LL: lower limb; LIFT: lower-limb intensive functional training; SC: standard care; UC: usual care; AHA: assisting hand assessment test; BBT: Box and Block Test; PEM-CY: participation and Environment Measure; CPQol: children and youth and cerebral palsy Quality of life, CIMT: constraint induced movement therapy; mCIMT: modified constraint induced movement therapy; OT: occupational therapist, PMAL: Pediatric Motor Activity Log, NS: not specified; TR: telerehabilitation; HF: hand function; CGs: caregivers, GS: grip strength; QUEST: Quality of Upper Extremity Skills Test, TM: telemonitoring; RM: remote monitoring; RS: remote support; DM: dissociated movement; WB: weight bearing; PR: protective reaction.

Outcomes reported

Upper extremity function-related parameters: Nine studies reported UE-related motor and functional abilities.^23–31

Occupational performance: Occupational performance was reported in two studies.^23,29

Activities of daily living : Six studies reported the use of UL in ADL.^{23,25,27–29}^,31

Motor and processing skills: Two studies reported motor and processing skills.^23,29

Other parameters : One study each reported visual perception,²³ carers’ perception of hand function,²⁶ and usability and acceptability.²²

Narrative synthesis

Effects of the interventions

Effects of bimanual training/therapy : The findings of the studies show that HB UE bimanual training/therapy improved hand coordination,³¹ dexterity, and execution of functional goals²⁴ in children with spastic UCP. Additionally, the H-HABIT regimen after modified constraint-induced movement therapy (mCIMT) demonstrates the potential to sustain the therapeutic benefits achieved during the initial mCIMT, thus reducing post-treatment regression in children with UCP.²⁸

Effects of AOT: The results of the studies revealed that Tele-monitored Upper Limb Children Action Observation Training (Tele-UPCAT) delivered HB AOT was feasible in children and adolescents with spastic UCP, and the Tele-UPCAT system showed usability and acceptability for HB training.²² In addition, post-training, the AOT group showed significant improvement in bimanual hand function compared to the standard care group, with improvements persisting for up to 6 months.²⁵ However, it was shown that there was no significant improvement in hand function when comparing the use of AO + repeated practice to repeated practice alone in children with UCP.²⁷

Effects of web-based multimodal therapy (Mitii therapy) : The findings showed that Mitii therapy resulted in significantly more responders on both AMPS and COMP functional measures in children and adolescents with spastic UCP.²⁹ Mitii therapy also results in significant improvements in occupational performance, goal attainment, visual processing, and ADL motor and processing skills in children with spastic UCP.²³ However, no between-group differences were observed in terms of impaired UE function.²³

Effects of Wii Sports Resort™ training : One study²⁶ found no differences between groups in coordination, hand function, or caregivers’ perceptions of hand function quality. However, the experimental group showed trends toward greater grip strength by 6 and 12 weeks, and caregivers perceived higher hand function quantity by 6 weeks and strengthened by 12 weeks.

Effects of modified constraint-induced movement therapy: A study³⁰ demonstrated improved UE function in both groups. Notably, a significant difference favored the study group in post-treatment mean values, highlighting the effectiveness of combining telerehabilitation program with mCIMT, as opposed to mCIMT in the context of home activities.

Telerehabilitation-monitored HB therapies demonstrated consistent positive improvements in UE function-related outcomes across the majority of studies in children and adolescents with UCP (predominantly spastic UCP studies) (low certainty of evidence due to high ROB and imprecision).

Discussion

This systematic review aimed to assess the scientific evidence on the effects of TR-monitored HB therapies on UE function-related outcomes in children and adolescents with CP. The major findings of this systematic review indicated that TR-monitored HB therapies showed consistent positive improvements in UE function-related outcomes. These improvements include hand coordination, dexterity, bimanual hand function, ADL motor and processing skills, occupational performance, and the execution of functional goals in children with UCP (predominantly spastic UCP studies).

The results showed that HB UE bimanual training/therapy improved hand coordination, dexterity, and execution of functional goals. Such improvements could enable children with UCP to perform everyday tasks requiring UE function more efficiently. This is crucial because mobility difficulties are defining features of Children with CP and are the focus of extensive therapeutic interventions.³² It is noteworthy that the observed positive impact may not solely result from bimanual training or therapy. Instead, this may be attributed to the emphasis on and integration of tele-coaching/remote monitoring and telerehabilitation in home-based training. This suggests that the combination of monitored home-based training and telerehabilitation is advantageous in assisting children with UCP in the effective performance of UE-related activities. This is significant because most ADLs require the coordinated use of both hands, and enhancing the functionality of the more affected UE to improve daily activities, including grooming, eating, and dressing, is important.³³ In addition, the findings are important because good UE coordination is crucial for the required functioning in everyday life.³⁴

The improvements due to H-HABIT can be attributed to various reasons: intensive rehabilitation interventions, rooted in the principles of motor learning, involve children in the practice of skillful movements, with enhancements in UE function posited to be linked to neuroplastic adaptations.³⁵ The HABIT process emphasizes bimanual coordination skills in the hands while preserving the intensive characteristics of constraint therapy.³⁶ In addition, the intervention incorporates a structured approach to practicing bimanual hand function through activities that are both child-friendly and selected by the children themselves based on their personal objectives and preferences.³⁶ This is supported by the statement that HABIT enhances UE function in children with CP and extends beyond typical bilateral coupling or mirror movements, integrating asymmetrical hand movements, and employing neuroplasticity and motor learning principles.³⁷ Furthermore, the implementation of synchronous telerehabilitation or telemonitoring in two studies on H-HABIT may have contributed to the favorable outcomes. These approaches potentially facilitate error-free exercises, enhance motivation, and promote increased practice and repetition.

The findings of a study indicated that Tele-UPCAT delivered HB AOT was feasible, and the Tele-UPCAT system showed usability and acceptability for HB training in children and adolescents with spastic UCP. In another study, AOT also demonstrated a significant improvement in bimanual hand function in children and adolescents with spastic UCP after treatment. These positive effects underscore the crucial role of HB AOT when combined with telerehabilitation and monitoring on these parameters in children and adolescents with UCP. This finding is advantageous because the premotor cortex serves as an alternative target due to its greater chances of survival and extensive connections within the motor network.³⁸ Additionally, improved bimanual function may facilitate more effective execution of activities using the UE. Hence, administering HB AOT alongside telerehabilitation and monitoring in children with UCP will be beneficial for their rehabilitation process.

The positive effects of AOT may stem from the fact that it holds significant promise for promoting motor recovery by activating the mirror neuron system through the observation and imitation of actions, and may enhance the effects of conventional therapies, and offers a novel mechanism to facilitate neuroplasticity.³⁹ This can be supported by the statement that AOT involves watching others’ actions and aligning them to internal representations, and observing the actions creates an internal representation of movement in the brain, enhancing motor memory and performance.⁴⁰ Additionally, another reason may be that AOT leverages the mirror mechanism in a more direct manner than mirror therapy, as it involves patients observing everyday activities carried out by other healthy individuals.⁴¹ Moreover, the implementation of the Tele-UPCAT system in certain studies may have influenced the effects of the interventions.

Mitii therapy has a positive impact on occupational performance, goal attainment, visual processing, and ADL motor and processing skills. The improvements are possible because, in addition to the therapy being a web-based multimodal, there were live interactions and constant communication and monitoring through e-mails, telephone calls, and Skype calls. This highlights the crucial role of integrating telerehabilitation with monitoring. Improvement in ADL motor and processing skills, along with occupational and functional performance measures, is essential for enabling children with spastic UCP to perform daily tasks involving the UE with minimal difficulty. The positive effects of Mitti therapy may be due to certain factors: repetitive, intensive, and progressively demanding training is required to induce brain plasticity.⁴² This is supported by the assertion that Mitii provides intensive and progressively challenging training in the cognitive, visual perceptual, and physical function domains.⁴³ In addition, web-based comprehensive training that enhances motor and cognitive skills through interdisciplinary virtual trainers may serve as a cost-efficient method for providing therapy and promoting skills translation into community and home environments.⁴²

The findings also revealed a trend of increased grip strength due to Wii Sports Resort Training in one study, while another study showed improved UE function due to mCIMT. The positive effect of Wii training could be due to certain factors. While mirror neurons contribute substantially owing to the multimodal stimulation offered by Nintendo Wii treatment (NWT), the advantages of NWT are mainly due to motor learning and neuroplasticity.⁴⁴ Additionally, it has been reported that considering the repeated practice, specific tasks, multisensory integration, and intensity that NWT facilitates, it is plausible to induce activity-dependent neuroplasticity.⁴⁴ These assertions are corroborated by prior suggestions indicating that, given the capacity of Wii Fit training to influence neural plasticity, such training could serve as a movement-priming adjunct to rehabilitation.⁴⁵ Other factors might be linked to HB and the adherence nature of the training, as research indicates that HB Wii Fit training is both safe and feasible, potentially offering benefits for children with CP, with the Wii Fit games suggested to offer both motivation and enjoyment, resulting in nearly complete adherence.⁴⁶ Moreover, it has been reported that a critical determinant of the efficacy of any intervention is the duration allocated to training and rehabilitation activities, a concept referred to as dosing.⁴⁷ Therefore, these factors likely contributed to the findings.

The observed effect of mCIMT can be attributed to the key principles of CIMT. They include counteracting maladaptive plasticity in patients with unilateral hemispheric damage (congenital or acquired), and constraining the nonparetic extremity while conducting an intensive motor activity training targeting the affected extremity with the goal of enhancing function.⁴⁸ Furthermore, it has been documented that activity-dependent cortical reorganization associated with CIMT may constitute the neural foundation for long-term enhancement in the utilization of the affected limb during daily activities post-treatment.⁴⁹ One significant limitation is that the findings on Wii training and mCIMT are each based on single studies, providing insufficient evidence for definitive conclusions to be drawn. Further research is needed in these areas.

Importantly, the positive effects of the therapies observed may be greatly attributed to the home-based nature of the training and the use of telerehabilitation or telemonitoring. The HB nature of the interventions is crucial, as research has reported that an essential advancement in rehabilitation practice is the sustained implementation of training within the child's everyday life and home environment, empowering the parents, and enhancing the autonomy of both the parents and the child from healthcare professionals.⁵⁰ Additionally, administering therapy in a home setting offers the benefit of being more resourceful, as it is more supportive, comfortable, meaningful, and welcoming for children compared to the daunting atmosphere of clinical or hospital facilities.⁵¹ These assertions could be supported by the findings that home-based rehabilitation, whether face-to-face or via telerehabilitation, is regarded as more accessible and convenient than services in facility setting.⁵² Furthermore, the success recorded with HB therapies may be attributed to its other unique characteristics, as HB training is recognized as a crucial intervention for the rehabilitation of children with CP, both currently and in the future, enabling parents to actively participate in their child's therapeutic regimen and allowing children to develop new skills within their familiar setting.⁵⁰

Furthermore, the implementation of telerehabilitation or tele/remote monitoring and supervision, whether conducted synchronously or asynchronously in the studies, may have positively influenced the outcomes, possibly due to various contributing factors. These include providing accessibility (removing barriers), and precision rehabilitation through telecommunication technologies.⁵³ There could also be improved treatment adherence through remote coaching/monitoring, as it has been reported that telemonitoring through a mobile application likely enhances adherence to exercise regimens.⁵⁴ Importantly, the successful implementation of this approach may demand critical consideration of various factors, as the effective deployment of remote patient monitoring necessitates addressing obstacles at the clinician, service, and patient levels, including considerations of technical quality, data governance, digital literacy, and reimbursement.⁵⁵ This aligns with a report that various factors affect the effective implementation of in-person home-based rehabilitation and telerehabilitation services, encompassing both facilitators and challenges.⁵² In essence, telemonitored home-based therapies may ensure practice and learning in real-world environments, thereby enhancing treatment outcomes.

This systematic review highlighted the crucial role of TR-monitored HB therapies in positively enhancing UE function-related outcomes in children and adolescents with UCP (predominantly spastic UCP studies). These therapies may ensure task practice and learning by children and adolescents with CP in real-world settings, thereby enhancing the treatment outcomes. These findings are essential for achieving optimal functionality. However, since the findings were primarily based on narrative synthesis and involved a limited number of studies, some of which had small sample sizes and certain methodological limitations. These factors may have influenced the outcomes of this review. Currently, the studies included represent the available and accessible studies in the subject area based on the focus and criteria of this review. The synthesized results and evidence indicate a positive effect of TR-monitored HB therapies on the outcomes of interest based on these accessible studies. Consequently, as more studies become available, further research with a larger number of studies and meta-analyses is necessary to substantiate this evidence.

Strengths and limitations

The primary strengths of this review encompass a comprehensive search of databases and additional sources, adherence to PRISMA guidelines, and the utilization of appropriate evaluation tools to assess the MQ and risk of bias ROB of the included studies. The studies included in the review had good MQ, and most of them had a low ROB in most domains of the Cochrane ROB tool, thereby enhancing the overall strength of the evidence. The primary limitation of this review is the absence of a meta-analysis for the outcomes, attributable to either an insufficient number of studies reporting these outcomes or the significant variability among the studies. Various factors contributed to the limitations of this systematic review, including differences in the administered HB interventions, variations in the control groups, diversity in the components of telerehabilitation employed, inconsistency in the outcome measures for certain outcomes across some studies, and technical challenges in the technologies used during the interventions. In addition, the review is susceptible to language and publication bias, as the exclusion of studies that are not in English or unpublished may lead to skewed results. The primary limitations identified in the included studies include a high ROB in the performance bias domain across the majority of the studies, and in most studies (five out of nine), the sample sizes were relatively small, with each involving fewer than 50 participants. Additionally, the included studies revealed shortcomings in safety reporting, as adverse events were not reported, underreported, or insufficiently captured in some studies, thereby restricting the evaluation of the associated potential harms. Therefore, further research is necessary to address these limitations and substantiate our findings.

Conclusions

Telerehabilitation-monitored home-based therapies showed potential to improve upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy (predominantly spastic UCP studies).

Supplemental Material

sj-docx-1-jtt-10.1177_1357633X261420104 - Supplemental material for Effects of telerehabilitation monitored home-based therapies on upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy: A systematic review

Supplemental material, sj-docx-1-jtt-10.1177_1357633X261420104 for Effects of telerehabilitation monitored home-based therapies on upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy: A systematic review by Jibrin Sammani Usman, Thomson Wai-Lung Wong and Shamay Sheung Mei Ng in Journal of Telemedicine and Telecare

Supplemental Material

sj-docx-2-jtt-10.1177_1357633X261420104 - Supplemental material for Effects of telerehabilitation monitored home-based therapies on upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy: A systematic review

Supplemental material, sj-docx-2-jtt-10.1177_1357633X261420104 for Effects of telerehabilitation monitored home-based therapies on upper extremity function-related outcomes in children and adolescents with unilateral cerebral palsy: A systematic review by Jibrin Sammani Usman, Thomson Wai-Lung Wong and Shamay Sheung Mei Ng in Journal of Telemedicine and Telecare

Footnotes

ORCID iDs

Jibrin Sammani USMAN

Thomson Wai-Lung Wong

Shamay Sheung Mei Ng

Ethical consideration

Not applicable

Consent to participate

Not applicable

Consent for publication

Not applicable

Author contributions

All authors contributed to the study design, conception, methodology, analysis, and interpretation of the data. JSU drafted the manuscript; JSU, TWLW, and SSMN critically revised the manuscript for important intellectual content. All authors have read and approved the final version of the manuscript.

Funding

This research was funded by a grant from the General Research Fund (Reference Number: 15126224) from the Research Grants Council of the Hong Kong SAR, China, awarded to Prof. Shamay S.M. Ng and her team.

Declaration of conflicting interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Data availability

Data will be made available by the corresponding author on reasonable request

Supplemental material

Supplemental material for this article is available online.

References

Feltham

Ledebt

Bennett

, et al. The “mirror box” illusion: Effect of visual information on bimanual coordination in children with spastic hemiparetic cerebral palsy. Motor Control 2010; 14: 68–82.

Ortega-Martínez

Palomo-Carrión

Varela-Ferro

Bagur-Calafat

, editors. Feasibility of a home-based mirror therapy program in children with unilateral spastic cerebral palsy. Healthcare; 2023: MDPI.

Weightman

Preston

Levesley

, et al. Home based computer-assisted upper limb exercise for young children with cerebral palsy: A feasibility study investigating impact on motor control and functional outcome. J Rehabil Med 2011; 43: 359–363.

Bruchez

Jequier Gygax

Roches

, et al. Mirror therapy in children with hemiparesis: A randomized observer-blinded trial. Dev Med Child Neurol 2016; 58: 970–978.

Auld

Johnston

Russo

, et al. A single session of mirror-based tactile and motor training improves tactile dysfunction in children with unilateral cerebral palsy: A replicated randomized controlled case series. Physiother Res Int 2017; 22: e1674.

Surana

Ferre

Dew

, et al. Effectiveness of lower-extremity functional training (LIFT) in young children with unilateral spastic cerebral palsy: A randomized controlled trial. Neurorehabil Neural Repair 2019; 33: 862–872.

Lorentzen

Greve

Kliim-Due

, et al. Twenty weeks of home-based interactive training of children with cerebral palsy improves functional abilities. BMC Neurol 2015; 15: 1–12.

Johnson

Williams

Gucciardi

, et al. Can an online exercise prescription tool improve adherence to home exercise programmes in children with cerebral palsy and other neurodevelopmental disabilities? A randomised controlled trial. BMJ open 2020; 10: e040108.

Özden

Özkeskin

. Physical exercise intervention via telerehabilitation in patients with neurological disorders: a narrative. 2022.

10.

Calabrò

Bonanno

Torregrossa

, et al. Do patients with severe acquired brain injury benefit from telerehabilitation? Promising results from a multicentric randomised controlled trial using non-immersive virtual reality. J Med Internet Res 2023; 25: e45458.

11.

Amorese

Ryan

. Home-based tele-exercise in musculoskeletal conditions and chronic disease: A literature review. Frontiers in Rehabilitation Sciences 2022; 3: 811465.

12.

Solis-Navarro

Gismero

Fernández-Jané

, et al. Effectiveness of home-based exercise delivered by digital health in older adults: A systematic review and meta-analysis. Age Ageing 2022; 51: afac243.

13.

Bates

Furber

Sherrington

, et al. Effectiveness of workshops to teach a home-based exercise program (BEST at home) for preventing falls in community-dwelling people aged 65 years and over: A pragmatic randomised controlled trial. BMC Geriatr 2022; 22: 66.

14.

Usman

Wong

TW-L

SSM

. Effects of home or community-based strength training on muscle, walking, mobility, and balance performances in patients with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord 2025; 98: 106413.

15.

Usman

Wong

TW-L

SSM

. Effects of transcranial direct current stimulation combined with concurrent dual-task walking on mobility, gait, and cognitive outcomes: A systematic review. Brain Res 2025; 1846: 149255.

16.

Usman

Wong

T-l

SSM

. Effects of treadmill training combined with transcranial direct current stimulation on mobility, motor performance, balance function, and other brain-related outcomes in stroke survivors: A systematic review and meta-analysis. Neurol Sci 2025; 46: 99–111.

17.

Maher

Sherrington

Herbert

, et al. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther 2003; 83: 713–721.

18.

Paci

Bianchini

Baccini

. Reliability of the PEDro scale: comparison between trials published in predatory and non-predatory journals. Arch Physiother 2022; 12: –9.

19.

Foley

Teasell

Bhogal

, et al. Stroke rehabilitation evidence-based review: Methodology. Top Stroke Rehabil 2003; 10: 1–7.

20.

Gonzalez

Moseley

Maher

, et al. Methodologic quality and statistical reporting of physical therapy randomized controlled trials relevant to musculoskeletal conditions. Arch Phys Med Rehabil 2018; 99: 129–136.

21.

Higgins

Altman

Gøtzsche

, et al. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. Br Med J 2011; 343: d5928.

22.

Beani

Menici

Ferrari

, et al. Feasibility of a home-based action observation training for children with unilateral cerebral palsy: An explorative study. Front Neurol 2020; 11: 16.

23.

James

Ziviani

Ware

, et al. Randomized controlled trial of web-based multimodal therapy for unilateral cerebral palsy to improve occupational performance. Dev Med Child Neurol 2015; 57: 530–538.

24.

Ferre

Brandão

Surana

, et al. Caregiver-directed home-based intensive bimanual training in young children with unilateral spastic cerebral palsy: A randomized trial. Dev Med Child Neurol 2017; 59: 497–504.

25.

Beani

Menici

Sicola

, et al. Effectiveness of the home-based training program tele-UPCAT (tele-monitored UPper limb children action observation training) in unilateral cerebral palsy: A randomized controlled trial. Eur J Phys Rehabil Med 2023; 59: 554–563.

26.

Chiu

Lee

. Upper limb training using wii sports resort for children with hemiplegic cerebral palsy: A randomized, single-blind trial. Clin Rehabil 2014; 28: 1015–1024.

27.

Kirkpatrick

Pearse

James

, et al. Effect of parent-delivered action observation therapy on upper limb function in unilateral cerebral palsy: A randomized controlled trial. Dev Med Child Neurol 2016; 58: 1049–1056.

28.

Hwang

Shin

Kim

, et al. Home-Based telerehabilitation to prevent post-modified constraint-induced movement therapy regression in unilateral cerebral palsy: A randomized controlled trial. Phys Occup Ther Pediatr 2025; 45: 711–728.

29.

Comans

Mihala

Sakzewski

, et al. The cost-effectiveness of a web-based multimodal therapy for unilateral cerebral palsy: The mitii randomized controlled trial. Dev Med Child Neurol 2017; 59: 756–761.

30.

Rezk

Aly

Kassem

, et al. Tele-rehabilitation for upper limb functions of children with hemiplegic cerebral palsy during COVID pandemic: Randomized controlled trial. Turk J Physiother Rehabil 2020; 32: 19287–19295.

31.

Ejaz

Tanveer

Shoukat

, et al. Effectiveness of routine physical therapy with or without home-based intensive bimanual training on clinical outcomes in cerebral palsy children: A randomised controlled trial. Physiother Q 2024; 32: 78–83.

32.

Sudati

Damiano

Rovai

, et al. Neural correlates of mobility in children with cerebral palsy: A systematic review. Int J Environ Res Public Health 2024; 21: 1039.

33.

Park

Choi

S-h

, et al. Relationship between the more-affected upper limb function and daily activity performance in children with cerebral palsy: A cross-sectional study. BMC Pediatr 2021; 21: 59.

34.

Shirota

Jansa

Diaz

, et al. On the assessment of coordination between upper extremities: Towards a common language between rehabilitation engineers, clinicians and neuroscientists. J Neuroeng Rehabil 2016; 13: 1–14.

35.

Bleyenheuft

Dricot

Gilis

, et al. Capturing neuroplastic changes after bimanual intensive rehabilitation in children with unilateral spastic cerebral palsy: A combined DTI, TMS and fMRI pilot study. Res Dev Disabil 2015; 43: 136–149.

36.

Ouyang

R-G

Yang

C-N

Y-L

, et al. Effectiveness of hand-arm bimanual intensive training on upper extremity function in children with cerebral palsy: A systematic review. Eur J Paediatr Neurol 2020; 25: 17–28.

37.

Meng

Tan

, et al. Short-term efficacy of hand-arm bimanual intensive training on upper arm function in acute stroke patients: A randomized controlled trial. Front Neurol 2018; 8: 26.

38.

Unger

Lowe

Beall

, et al. Stimulation of the premotor cortex enhances interhemispheric functional connectivity in association with upper limb motor recovery in moderate-to-severe chronic stroke. Brain Connect 2023; 13: 453–463.

39.

Donati

Farì

Giorgi

, et al. Evaluating the efficacy of action observation training in improving upper limb functionality in children with cerebral palsy: A scope review. OBM Neurobiology 2024; 8: 1–19.

40.

Özipek

Saricaoglu

Hanoğlu

, et al. Action observation therapy effects on motor function and balance in cerebral palsy: An fNIRS-based randomized trial. Trials 2025; 26: 465.

41.

Buccino

Molinaro

Ambrosi

, et al. Action observation treatment improves upper limb motor functions in children with cerebral palsy: A combined clinical and brain imaging study. Neural Plast 2018; 2018: 4843985.

42.

Boyd

Mitchell

, et al. Move it to improve it (Mitii): Study protocol of a randomised controlled trial of a novel web-based multimodal training program for children and adolescents with cerebral palsy. BMJ open 2013; 3: e002853.

43.

Piovesana

Ross

Lloyd

, et al. A randomised controlled trial of a web-based multi-modal therapy program to improve executive functioning in children and adolescents with acquired brain injury. Clin Rehabil 2017; 31: 1351–1363.

44.

Raipure

Kasatwar

. The effects of nintendo wii fit on postural balance control training in the geriatric population: A review. Cureus 2022; 14: e31420.

45.

Omiyale

Crowell

Madhavan

. Effect of Wii-based balance training on corticomotor excitability post stroke. J Mot Behav 2015; 47: 190–200.

46.

Chiu

H-C

Ada

Lee

S-D

. Balance and mobility training at home using Wii Fit in children with cerebral palsy: A feasibility study. BMJ open 2018; 8: e019624.

47.

Goble

Cone

Fling

. Using the Wii Fit as a tool for balance assessment and neurorehabilitation: The first half decade of “Wii-search”. J Neuroeng Rehabil 2014; 11: 12.

48.

Gulrandhe

Acharya

Patel

, et al. Pertinence of constraint-induced movement therapy in neurological rehabilitation: A scoping review. Cureus 2023; 15: e45192.

49.

Hoare

Thorley

Jackman

, et al. Constraint-induced movement therapy in children with unilateral cerebral palsy. Cochrane Database Syst Rev 2019; 2019: CD004149.

50.

Schnackers

Beckers

Janssen-Potten

, et al. Home-based bimanual training based on motor learning principles in children with unilateral cerebral palsy and their parents (the COAD-study): Rationale and protocols. BMC Pediatr 2018; 18: 139.

51.

Mahmood

Habibullah

Aurakzai

. Effectiveness of simple and basic home-based exercise programs including pediatric massage executed by caregivers at their homes in the management of children with spastic cerebral palsy: A randomized controlled trial. J Pediatr Rehabil Med 2024; 17: 97–106.

52.

Velez

Lugo-Agudelo

Patiño Lugo

, et al. Factors that influence the provision of home-based rehabilitation services for people needing rehabilitation: A qualitative evidence synthesis. Cochrane Database Syst Rev 2023; 2: Cd014823.

53.

Willingham

Stowell

Collier

, et al. Leveraging emerging technologies to expand accessibility and improve precision in rehabilitation and exercise for people with disabilities. Int J Environ Res Public Health 2024; 21: 79.

54.

Krkoska

Vlazna

Sladeckova

, et al. Adherence and effect of home-based rehabilitation with telemonitoring support in patients with chronic non-specific low back pain: A pilot study. Int J Environ Res Public Health 2023; 20: 1504.

55.

Hamann

Knitza

Kuhn

, et al. Recommendation to implementation of remote patient monitoring in rheumatology: Lessons learned and barriers to take. RMD open 2023; 9: e003363.