Correlations between Epstein-Barr virus antibody levels and risk factors for multiple sclerosis in healthy individuals

Abstract

Background Female gender, human leukocyte antigen (HLA) DR2, tobacco smoking and Epstein-Barr virus (EBV) are established risk factors for multiple sclerosis (MS). Their possible interaction however, has been sparsely studied.

Objectives To investigate possible associations between EBV antibody levels and a range of other recognized MS risk factors.

Design, setting and study population Cross-sectional study undertaken in Denmark based on 517 healthy individuals selected from the Danish population.

Methods We measured change in mean log (anti-Epstein-Barr viral capsid antigen (VCA) immune globulin G) using linear regression.

Results Anti-Epstein-Barr VCA immune globulin G levels were positively correlated with female gender and HLA DR2. Furthermore, current smoking and cumulative tobacco consumption were positively associated with EBV antibody levels.

Conclusion The association between Epstein-Barr VCA antibody levels and non-viral MS risk factors support the view that EBV is critically involved in the etiology of MS. These non-viral MS risk factors may be linked with MS risk through EBV-specific immune responses. Multiple Sclerosis 2007; 13: 420-423. http://msj.sagepub.com

Keywords

Epstein-Barr virus antibodies gender HLA-DR2 multiple sclerosis tobacco smoking

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References

Duquette P. , Pleines J. , Girard M. , Charest L. , Senecal-Quevillon M. , Masse C. The increased susceptibility ofl women to multiple sclerosis . Can J Neurol Sci 1992; 19: 466-71 .

Jersild C. , Fog T. , Hansen GS , Thomsen M. , Svejgaard A. , Dupont B. Histocompatibility determinants in multiple sclerosis, with special reflerence to clinical course . Lancet 1973; 2: 1221-25 .

Levin LI , Munger KL , Rubertone MV , Peck CA , Lennette ET , Spiegelman D. et al. Temporal relationship between elevation ofl Epstein-Barr virus antibody titers and initial onset ofl neurological symptoms in multiple sclerosis . JAMA 2005; 293: 2496-500 .

Haahr S. , Koch-Henriksen N. , Moller-Larsen A. , Eriksen LS , Andersen HM Increased risk ofl multiple sclerosis aflter late Epstein-Barr virus inflection: a historical prospective study . Mult Scler 1995; 1: 73-77 .

Hernan MA , Olek MJ , Ascherio A. Cigarette smoking and incidence ofl multiple sclerosis . Am J Epidemiol 2001; 154: 69-74 .

Oldstone MB Molecular mimicry and autoimmune disease . Cell 1987; 50: 819-20 .

Lang HL , Jacobsen H. , Ikemizu S. , Andersson C. , Harlos K. , Madsen L. et al. A flunctional and structural basis flor TCR cross-reactivity in multiple sclerosis . Nat Immunol 2002; 3: 940-43 .

Munch M. , Riisom K. , Christensen T. , Moller-Larsen A. , Haahr S. The significance ofl Epstein-Barr virus seropositivity in multiple sclerosis patients ? Acta Neurol Scand 1998; 97: 171-74 .

Pedersen M. , Jacobsen S. , Klarlund M. , Frisch M. Socioeconomic status and risk ofl rheumatoid arthritis: a Danish case-control study . J Rheumatol 2006.

10.

Kimura A. , Sasazuki T. Eleventh International Histocompatibility Workshop reflerence protocol flor the HLA DNA typing technique. In Tsuji K , Aizawa M , Sasazuki T eds. HLA 1991, Volume 1. Oxflord University Press , 1992.

11.

Lio D. , Caccamo N. , D'Anna C. , Cigna D. , Candore G. , Caruso C. Viral antibody titers are influenced by HLA-DR2 phenotype . Exp Clin Immunogenet 1994; 11: 182-86 .

12.

Horwitz CA , Henle W. , Henle G. , Rudnick H. , Latts E. Long-term serological flollow-up ofl patients flor Epstein-Barr virus aflter recovery flrom inflectious mononucleosis . J In fect Dis 1985; 151: 1150-53 .

13.

Wagner HJ , Hornef M. , Teichert HM , Kirchner H. Sex diflflerence in the serostatus ofl adults to the Epstein-Barr virus . Immunobiology 1994; 190: 424-29 .

14.

Boyer KM , Sumaya CV , Cherry JD , Spencer MJ , Mickey MR , Terasaki PI Histocompatibility antigens and humoral immunity to Epstein-Barr virus . Tissue Antigens 1980; 15: 105-11 .

15.

Ascherio A. , Munger KL , Lennette ET , Spiegelman D. , Hernan MA , Olek MJ et al. Epstein-Barr virus antibodies and risk ofl multiple sclerosis: a prospective study . JAMA 2001; 286: 3083-88 .

16.

Delorenze GN , Munger KL , Lennette ET , Orentreich N. , Vogelman JH , Ascherio A. Epstein-Barr virus and multiple sclerosis: evidence ofl association flrom a prospective study with long-term flollow-up . Arch Neurol 2006; 63: 839-44 .

17.

Sopori ML , Kozak W. Immunomodulatory eflflects ofl cigarette smoke . J Neuroimmunol 1998; 83: 148-56 .

18.

Sundstrom P. , Juto P. , Wadell G. , Hallmans G. , Svenningson A. , Nystrom L. et al. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study . Neurology 2004; 62: 2277-82 .