Abstract
Background:
The aim of this study was to investigate the magnitude and associated factors of alcohol use disorder among the elderly living in 3 towns in South West Ethiopia.
Method:
Cross-sectional community-based study was done among 382 elderly people aged 60 or more from February to March 2022 in South West Ethiopia. The participants were selected by a systematic random sampling method. Alcohol use disorder, quality of sleep, cognitive impairment, and depression were assessed by using AUDIT, Pittsburgh Sleep Quality Index, Standardized Mini Mental State Examination, and geriatric depression scale, respectively. Also, suicidal behavior, elder abuse, and other clinical and environmental factors were assessed. The data was entered into Epi Data Manager Version 4.0.2 before being exported to SPSS Version 25 for analysis. A logistic regression model was used, and variables with a P-value less than .05 in the final fitting model were stated as independent predictors of alcohol use disorder (AUD).
Result:
The magnitude of alcohol use disorder, current alcohol use, and life-time alcohol use among the elderly was 27.5%, 52.4%, and 89.3%, respectively. Also, 7%, 23%, 8.9%, and none of the elderly had nicotine, khat, inhalants, and cannabis use disorder, respectively. Furthermore, AUD was associated with cognitive impairment (AOR, 95% CI; 2.79 (1.47-5.30)), poor sleep quality (AOR, 95% CI; 3.27 (1.23-8.69)), chronic medical illness (AOR, 95% CI; 2.12 (1.20-3.74)), and suicidal ideation (AOR, 95% CI; 5.27 (2.21-12.60)).
Conclusion:
Problematic alcohol use was higher among the elderly, and cognitive impairment, poor sleep quality, having chronic medical illness, and suicidal ideation were risk factors for AUD. Therefore, community level screening for AUD and comorbid risk factors among this particular age group and managing them is crucial to prevent further complications due to AUD.
Background
Alcohol use disorder (AUD) was the most prevalent of all substance use disorders, and about 99.2 million disability-adjusted life years were attributable to alcohol use disorder among the general population. 1 Substance use disorder is a significant issue for the social, economic, and health well-being of communities, individuals, and families. More than 2 billion people drink alcohol; more than 1 billion people smoke tobacco, and about 185 million people use other drugs. 2 The elderly with psychoactive substance use disorder are increasingly consuming alcohol and other substances.3-6 Elderly people are susceptible to AUD for the following reasons; changes in body composition and metabolism, and underlying medical comorbidities. 3
AUD is linked to marked limitations in social, psychological, physical, and cognitive functioning. A person with an AUD is 5 times more likely to have a psychiatric disorder. 7 AUD is responsible for depressive disorders and alcohol withdrawal symptoms in the elderly. 8 The elderly with problematic alcohol use are at a greater risk of economic deprivation, social isolation, and the rapid development of dependence.3,9 Comorbidity between AUD and depression, dementia, and other physical and psychiatric illnesses is common in the elderly.3,10 Problematic alcohol use is linked with elder victimization,11-16 being male, poor health, social isolation, cognitive loss, falling injuries, and an elevated risk of infectious disease, using other psychoactive substances,9,17-19 unstable housing,20,21 suicidal behaviors,22,23 and mortality.24,25
Problematic alcohol use can affect sleep quality in several ways. Several studies have disclosed that problematic alcohol consumption causes poor quality of sleep characterized by frequent bedtime awakenings. 26 It is known that people with insomnia frequently consume alcohol before going to bed in order to improve their sleeping patterns.27-29 Moderate alcohol consumption is thought to be a preventive factor for mortality,27-29 whereas problematic alcohol consumption can increase the risk of mortality from various illnesses. 30 ,31-34 AUD can also cause several neuropsychiatric disorders; such as peripheral neuropathy, movement disorders, and low learning ability.35,36 AUD has also been linked to cognitive dysfunction in several studies.37-43
Despite all these complications associated with problematic alcohol consumption among people of advanced age, alcohol and alcohol-related problems are misdiagnosed, underdiagnosed, and undertreated. 44 Despite the many impacts alcohol has on elderly people, such as increased mortality, psychiatric and physical health problems, and increased social and economic burden, little is known about the magnitude of AUD and risk factors associated with problematic alcohol use among elderly people in our country, Ethiopia, or elsewhere. Therefore, the aim of this study was to assess the magnitude of AUD and its associated factors among the elderly aged 60 and above in 3 selected towns in south west Ethiopia.
Methods and Materials
Study design, setting, and period
The current study was carried out in Tepi, Bonga, and Mizan-Aman towns among elderly people aged 60 and above from February to March 2022. Tepi, Bonga, and Mizan-Aman towns were situated 611, 460, and 561 km away from the capital city of Ethiopia, respectively. Tepi and Bonga towns each have 1 general hospital and 1 health center, while Mizan Aman town has 2 health centers and 1 teaching hospital.
Study design and population
A cross-sectional study design was used, and the elderly who were living in towns in Ethiopia and those who met the eligibility criteria were considered the source and study population, respectively. The elderly who lived for 6 months or more were included in the study, while those with communication impairments and those who could not respond as a result of severe psychiatric or physical illness were not included in the study.
Sample size determination and sampling techniques
A single population proportion formula was used to determine the sample size. A prevalence (p) of 50% was used since no similar study was carried out in our country among elderly people aged 60 and above. A 95% confidence interval, a 0.05 margin of error, and a 10% non-response rate was used, and the final sample size was 422. A probability-based systematic random sampling technique was used. Mizan-Aman, Bonga, and Tepi towns were specifically chosen due to their large elderly populations. Thirty percent of each town’s kebele were chosen. The sample size was distributed proportionally as per the number of households in each kebele. The total numbers of elderly in Miza Aman town were 1324, those in Bonga town were 1040, and those in Tepi town were 845. The respondents’ households were obtained from family health extension workers assigned in each town. After the initial household was selected randomly, every kth household was recruited after labeling each individual household. In a case of 2 or more elderly people in a single household, a lottery method was employed to select one of them.
Study variables, data collection tools, and measurement
AUD was the dependent variable in the current study. Religion, age, marital status, educational level, ethnicity, employment status, income status, and clinical factors (sleep quality, cognitive impairment, depression, suicidal behaviors, and chronic medical illness) were all included as independent variables.
AUD was screened using the Alcohol Use Disorder Identification Test (AUDIT). It is a tool used to screen for heavy alcohol use and identify AUD in the elderly.45,46 The cutoff score indicating alcohol use disorder is 8. The reliability (Cronbach’s α) of AUDIT in this study was .91. ASSIST, a standardized tool, was also used to assess lifetime and current alcohol use. 47
Other substances’ (khat, nicotine, cannabis, inhalants, and caffeine) use patterns were assessed using the DSM V criteria for substance use disorder, which included the following parameters: the amount of specific substance use for at least a year; having the desire to cut down or stop; spending a significant amount of time while using or obtaining a substance; the strong desire to use the substance; continuing substance use despite persistent social problems; preferring substance use over family, occupational, and recreational activities; using a substance in situations where it is physically hazardous (while driving, manipulating a machine, etc.); using a substance despite knowing that it has psychological and/or physical health problems; increasing the dose of the substance to achieve the desired effect or reduced efficacy when the usual amount is used; and experiencing psychological or physiological symptoms if the dose is decreased or stopped at all. In order to qualify for a substance use disorder, the elderly must meet 2 out of the 11 criteria for at least a year. An elderly person with mild substance use disorder must fulfill 2 to 3 of the 11 criteria, and an elderly person with moderate substance use disorder must fulfill 4 to 5 of the 11 criteria. In addition, if the elderly met 6 or more out of the 11 criteria, they had a sever substance use disorder. 48
Cognitive impairment was assessed with the Standardized Mini Mental State Examination (SMMSE) tool; respondents with grade levels of less than or equal to 8 had scores of less than or equal to 22, and respondents with grade levels of grade 9 or more had marks of 24 or more from the score of 30.49,50 The reliability of this tool in the current study was 0.79.
The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality in the elderly. It is a tool for assessing sleep patterns and quality in the elderly. It measures 7 components of sleep to differentiate “poor quality of sleep from good” by assessing the following dimensions: latency of sleep, subjective quality of sleep, duration of sleep, habitual efficiency of sleep, disturbances of sleep, sleep medications used, and daytime dysfunction that happened due to a poor sleeping pattern in the last 1 month. A Likert scale of 0 to 3 was used to assess individual variables, with a score of 0 shows a positive response and a score of 3 shows a negative response. A total PSQI score of greater than 5 means the elderly have poor sleep quality. 51 The reliability of this tool in this study was 0.81.
Previous studies used the Geriatric Depression Scale to screen for depression in the elderly population, and this tool was widely used among the elderly in Ethiopia.52,53 Geriatric depression scales consist of 15 questions to screen for depression among the elderly. The overall score of 5 or more was indicative of depression in the elderly. 54 The reliability of this tool in this study was 0.86. Social support was measured by using the Oslo-3 social support tool with the following categories; scores of 3 to 8 was indicative of poor social support, scores of 9 to 11 was indicative of moderate social support, and scores of 12 to 14 was indicative of good social support. 55 Suicidal behaviors were assessed with the following question: “have you ever had suicidal ideation or attempt?” The elderly were abused if they responded positively to 1 or more of the 5 elder abuse items listed below. Physical abuse is positive if the respondent had 1 or more positive responses to physical abuse items; such as hitting, kicking, pushing, slapping, burning, and other events that cause bodily harm or pain. Psychological abuse is positive if the respondent was humiliated by someone. If the elderly failed to meet a basic need he or she had care giver neglect. Financial abuse is positive if there is 1 or more positive responses to one of the following events: illegally misusing an elderly person’s money, property, or assets. In addition, if the elderly had 1 or more positive responses from the sexual abuse items, such as forced sexual acts, he or she had sexual abuse,56,57
Data quality control
An interview administered questionnaire was used to collect the data. An English-language version of the tools was translated into the Amharic version, which is the local official language of the study area. The data was collected by 3 data collectors with a degree in clinical psychiatry and supervised by an expert in the field of psychiatry. The collected data was evaluated for clarity, completeness, and consistency on a daily basis.
Data processing and analysis
The Epi Data Manager Version 4.0.2 was used to code and enter the collected data before it was exported to SPSS for further analysis. Descriptive statistics such as mean and standard deviation were computed for different variables. After bivariate logistic regression, candidate variables with a P-value <.25 were transferred to the final multivariable logistic regression model. In the final model, the adjusted odds ratio with a corresponding 95% confidence interval was used to indicate the level of significance for AUD.
Results
Socio-demographic characteristics of the study participants
Of the total of 422 participants eligible to participate, only 382 elderly people participated, whose response rate was 90.5%. The mean age of the respondents age in a year was 67. The most common characteristics by religion, sex, age group, marital status, occupation, and ethnicity were being a follower of an orthodox church, being female, being in the age group of 60 to 69 years, being married, being a farmer, and being part of the Kefa ethnic group, respectively. Socio-demographic data is given below in Table 1.
The socio-demographic factors of elderly from 3 selected towns in south west, Ethiopia, 2022 (n = 382).
The prevalence of alcohol and other substance use disorders
Of the total respondents, 105 (27.5%), 200 (52.4%), and 341 (89.3%) of the elderly had AUD, current alcohol use, and lifetime alcohol use, respectively. Of the total participants, 89 (23%) had khat use disorders; among them, 62 (16.2%), 7 (1.8%), and 20 (5%) had mild, moderate, and severe khat use disorders, respectively. Of the total participants, 27 (7%) had nicotine use disorders. Among them, 4 (1%), 8 (2%), and 15 (4%) had mild, moderate, and severe nicotine use disorders, respectively. Of the total participants, 34 (8.9%) had inhalant use disorders; among them, 22 (5.8%), 0 (0%), or none of them, and 12 (3%) had mild, moderate, and severe inhalant use disorders, respectively. Of the total participants, 300 (78.9%) had caffeine use disorders. Of them, 188 (49.5%), 106 (27.9%), and 6 (1.6%) had mild, moderate, and severe caffeine use disorders, respectively. Furthermore, none of the elderly in this study had a cannabis use disorder (See Table 2).
Prevalence of AUD and substance use disorder of elderly from 3 selected towns in south west, Ethiopia, 2022 (n = 382).
The clinical and social-related variables
Almost one-fourth of the total participants (27.5%) had a chronic physical illness, and almost none of the respondents had regular physical exercise. Nearly half of the respondents had poor social support, and about 1 in 10 (9.4%) of the elderly were known HIV positive patients. Furthermore, almost half (210, 55%) of the elderly were screened positive for poor quality of sleep. In addition, more than 1 in 3 elderly people (141, 37%) had depression, and 55 (14.4%) of the elderly had suicidal ideation or attempt. Besides, 135 (35.3%) of the elderly people were screened positive for cognitive impairment (Table 3).
Prevalence of clinical and social factors of elderly from 3 selected towns in south west, Ethiopia, 2022 (n = 382).
Factors associated with alcohol use disorder
According to the bivariate analysis, being 60 to 69 years of age, being male in sex, having khat use disorder, having physical illness, being in a family with poor support, living alone, having poor quality of sleep, having cognitive impairment, being depressed, having suicidal ideation or attempt, and having elder abuse were all associated with alcohol misuse. However, the final fitted model (multivariate logistic regression) showed the following variables; cognitive impairment (AOR = 2.53, 95% CI = 1.18-5.42), poor sleep quality (AOR = 2.67, 95% CI = 1.10-6.44), physical illness (AOR = 3.27, 95% CI = 1.49-7.15), and suicidal ideation or attempt (AOR = 2.07, 95% CI = 1.06-4.40) were all positively associated with AUD among the elderly in this study (See Table 4).
AUD and associated factors in both bi-variate and multivariate logistic regression analysis of elderly from 3 selected towns in south west, Ethiopia, 2022 (n = 382).
Abbreviations: AOR, adjusted odds ratio; COR, crude odds ratio.
1 = reference category.
Discussion
The aim of this study was to determine the magnitude of AUD and associated risk factors among elderly people aged 60 or more. Accordingly, the prevalence of AUD, current use of alcohol, and life-time use of alcohol was 27.5%, 52.4%, and 89.3%, respectively. Moreover, cognitive impairment, poor sleep quality, having a self-reported medical condition, and suicidal ideation or attempt were positively associated with AUD among the elderly.
The magnitude of problematic alcohol use in this study was lower than the study done in Brazil, where current alcohol use was 100%, and higher than the studies conducted in South Africa, where current and life-time alcohol use rates were 10.7% and 23.7%, respectively,58,59 and Nigeria, where current and life-time alcohol use rates were 15.6% and 45.2%, respectively. 19 The rate of alcohol use in this study was 27.5%, which was higher than the studies conducted in Brazil and Nigeria.58,60,61 The difference can be explained by the variation in culture and screening tool differences among studies. Another possible explanation for why AUD was high in the current study might be the availability of alcoholic drinks. Most alcoholic drinks are culturally fermented and used by the elderly in Ethiopia. For example, an alcoholic drink known as tella replaces water in the culture of Ethiopia, and it is believed that drinking tella is better than drinking pure water. Therefore, tella is available in almost every house and is given to the elderly, women, children, pregnant mothers, and adults instead of drinking pure water. Furthermore, Teji and Arake (almost 40% pure alcohol content) are locally produced alcoholic drinks that any woman can make at home and are used by the elderly and other segments of the population.
This study also discovered that poor quality of sleep was strongly associated with AUD. The current finding was similar to studies done in other parts of the world.62-64 The possible explanation for the association could be that alcohol consumption has the following effects on the sleep cycle; alcohol use induces deep sleep during the initial phase of the sleep cycle, but, the quality of sleep is compromised when sleep continues longer as a result of the decreased slow wave sleep cycle and rapid eye movement sleep phase.26,65 Moreover, alcohol increases sleep-induced apnea by preventing the entry into deep sleep as a result of relaxing muscles in the upper airway and due to increased resistance during air entry into the lung, which can impede breathing severely.66-68
According to this study, cognitive impairment was positively linked with AUD. This is consistent with several other studies that found that elderly people with AUD were more likely to experience cognitive decline and impairment than their peers.39,69-72 The possible explanation could be due to the neurotoxic effects of alcohol, which might result in direct damage to brain structures or indirect effects such as metabolic toxicity, malnutrition, electrolyte disturbances, and physiological disorders such as infection and liver disease.73,74
Those with chronic physical illness were more likely to have an AUD than their counterparts in this study. This result is the same as another study, 75 and the possible explanation might be that long-lasting pain and emotional distress due to chronic medical illness might increase the risk of using alcohol as self-medication to temporarily alleviate pain. 76 The other reason could be that alcohol use might reduce the effectiveness of prescribed medications for the underlying medical illness. 77 Problematic alcohol uses might increase the probability of transmission of communicable diseases due to unprotected sexual intercourse among alcohol users due to their intoxication or alcohol blackout. 78 In addition to this, alcohol users might have decreased apatite, poor adherence to medication, a lack of follow-up for treatment, and a direct physiological effect on the body system that increases the possibility of physical illness by increasing the chance of infection. Furthermore, using a combination of multiple substances would affect treatment outcomes; For example; using khat and alcohol has a potential influence on the immunity of substance users, and vulnerable people could develop a series of adverse health effects.79-81
The current finding also discloses that suicidal ideation is a predictive factor for alcohol misuse, and this finding is consistent with other comparable studies.22,82 This association can be explained by the fact that elderly people with problematic alcohol use might have difficulty in making decisions as well as controlling their impulses. 83 Another possible explanation could also be that elderly people experiencing suicidal behavior might use alcohol as self-medication or to hide themselves from reality. 83
Currently there are numerous evidences that problematic alcohol use is responsible for brain atrophy, dementia, and severe memory impairment. 84 There are also drugs like sodium oxybate, benzodiazepines, and disulfiram to help alcohol withdrawal and alcohol abstinence in alcoholics to decrease alcohol craving, number of drinks per day, and prevent alcohol relapse. 85 Due to alcohol rehabilitation and treatment center is only located in the capital city of Ethiopia, the study region has no access to modern rehabilitation center. Therefore, this finding highlights the need to establish a community-based mental health service to screen for alcohol misuse and psychiatric disorders due to alcohol misuse in the elderly and to provide early intervention and referral to better facilities. Even though a few referral hospitals have integrated mental health services in Ethiopia, access to mental health services is still insufficient due to a cultural belief that mental illness is caused by supernatural power, and their main choices of treatment are holy water and indigenous medical practices. As a result, nowadays, mental health services are not available in health posts, general hospitals, primary hospitals, or at the community level in Ethiopia. Due to this, the patient and family visit for traditional rituals like drinking holy water and using traditional herbal remedies. Finally, the recommendation to the federal and regional health ministers is to integrate psychiatric services with the primary, general, and tertiary hospitals and other health institutions in Ethiopia, and to use an integrated treatment model for alcohol use disorder and other psychiatric and physical comorbidities rather than treating AUD only.
Limitations of the study
The readers need to understand the following limitations in this study; recall bias, interviewer bias, substance users might deny using it, medical comorbidity was assessed only by a follow-up card, and being a cross-sectional study prohibits drawing causal inference.
Conclusion
This study showed about 1 in 4 elderly people had an AUD. In addition, having poor sleep quality, chronic medical illness, cognitive impairment, and having suicidal ideation or attempt were risk factors for AUD. Therefore, screening and intervention for alcohol misuse and its predictive factors among this particular age group is crucial. It is also imperative to provide proper health education toward alcohol misuse and factors associated with it among the elderly population. Further research is recommended to determine whether the current findings apply to other regions of the elderly in Ethiopia and elsewhere.
Footnotes
Acknowledgements
The author would like to thank the supervisors, data collectors, and respondents for their unreserved cooperation.
Funding:
The author received no financial support for the research, authorship, and/or publication of this article.
Declaration Of Conflicting Interests:
The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Author Contributions
The author made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; has agreed on the journal to which the article has been submitted; and agreed to be accountable for all aspects of the work.
Ethical Approval
For the commencement of data collection, ethical clearance, and a supportive letter were obtained from Mizan Tepi University College of Health Sciences with Ref No: MTU/NR/317/14. Informed consent was obtained from study subjects. Personal identifiers were omitted to maintain the confidentiality of the information. Moreover, the collected data is kept safe throughout the whole data collection and analysis process. This study was conducted in accordance with the Helsinki declaration for research ethics.
Data Availability
Data will be available from the corresponding author upon reasonable request.