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Abstract

Keywords

Conclusion

In a 1996 safety assessment of HC Red No. 1, the Cosmetic Ingredient Review Expert Panel stated that this ingredient is safe as used in hair dye formulations at concentrations of <0.5%.¹ The Expert Panel reviewed newly available studies since that assessment along with updated information regarding types and concentration of use.^2

–8 The Expert Panel confirmed that HC Red No. 1 is safe as a hair dye ingredient at concentrations of <0.5%, as given in Table 1 and did not reopen this safety assessment.

Table 1.

Historic and Current Uses and Concentrations of HC Red No.1.^1,4,6

	HC Red No. 1
	No. of uses		Concentration of use, %
Data year	1996	2011	1996	2011
Totals	47	9	<0.5	0.07
Duration of use
Leave-on	NR	NR	NR	NR
Rinse-off	47	9	≤0.5	0.07
Exposure type
Eye area	NR	NR	NR	NR
Possible ingestion	NR	NR	NR	NR
Inhalation	NR	NR	NR	NR
Dermal contact	NR	NR	NR	NR
Deodorant (underarm)	NR	NR	NR	NR
Hair—noncoloring	NR	NR	NR	NR
Hair-coloring	47	9	≤0.5	0.07
Nail	NR	NR	NR	NR
Mucous membrane	NR	NR	NR	NR
Bath products	NR	NR	NR	NR
Baby products	NR	NR	NR	NR

Abbreviation: NR, not reported.

Discussion

HC Red No. 1 is a direct hair dye reported used in 47 hair-coloring products in 1996, based on voluntary reports¹ submitted to the US Food and Drug Administration by the industry, with concentrations of use <0.5%.⁶ In 2011, HC Red No. 1 was reportedly used in 9 cosmetic products.⁴ Data from an industry survey in 2011 indicated that this ingredient was used at 0.07%.⁶

Footnotes

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council.

References

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. International Cosmetic Ingredient Dictionary and Handbook. 13th ed. Washington, DC: Personal Care Products Council (formerly the Cosmetic, Toiletry, and Fragrance Association.); 2010.

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Scientific Committee on Consumer Products (SCCP). Opinion on HC Red no. 1 (COLIPA no. B48). European Commission Health & Consumer Protection Directorate-General. 2006. Report No. SCCP/0981/06. http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sccp_o_072.pdf.