A recent survey estimated that over 60 million people used unconventional therapies each year in the United States for a variety of ailments that included cancer pain, arthritis, acquired immunodeficiency syndrome (AIDS), gastrointestinal (GI) problems, incontinence, eating disorders, and headaches. The methods chosen included massage, acupressure, acupuncture, heat, cold, imagery, and biofeedback. Estimated out-of-pocket expenditure for those surveyed exceeded $10.3 billion per year. Health care providers have the opportunity to enhance cancer pain management, especially in the home setting, through the use of physical and cognitive methods. Optimal pain relief depends on a thorough nursing assessment, pharmacologic management, and appropriate nondrug interventions.