The appearance of circulating factor VIII:C (FVIII:C) inhibitors in nonhemophilic patients represents a rare condition characterized by spontaneous and often life-threatening bleeding. We describe a patient with ac quired idiopathic hemophilia in whom immunosuppres sive therapy associated with human FVIII infusion deter mined a prompt and complete disappearance of the inhib itor. Given the very low number of patients with acquired hemophilia and the lack of prospective randomized clin ical trials published, we hope to contribute to a better definition of the therapeutic strategy in these patients.
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