A 21-year-old girl with an ischemic bowel developed portal and splenic vein thrombosis 3 weeks later, despite thromboprophylaxis low-molecular-weight heparin. An extensive thrombophilia screen was negative and the only possible reason for her vascular occlusion was transient but severe eosinophilia. The role of transient eosinophilia in thrombosis is discussed in the light of other similar rare cases.
Fauci AS, Harley JB, Roberts WC, Ferrans VJ, Gralnick HR, Björnson BHThe idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations. Ann Intern Med. 1982;97(1):78-92.
2.
Sade K., Schwartz I., Lev E., Kivity S., Levo Y.Widespread thromboembolism in allergy. Allergy. 2001;56(3):253-254.
3.
Mukai HY, Ninomiya H., Mitsuhashi S., Hasegawa Y., Nagasawa T., Abe T.Thromboembolism in a patient with transient eosinophilia. Ann Haematol. 1996;72(2):93-95.
4.
Miyazaki H. , Yanagitani S., Matsumoto T., Yoshida K., Amoh Y., Watanabe T., et al. Hypercoagulopathy with piperacillin administration in osteomyelitis . Intern Med. 2000;39(5):424-427.
5.
Mates M., Nesher G., Roth B., Rosenberg R., Heyd R., Hershko C.Transient severe eosinophilia precipitating massive venous thrombosis in a patient with hereditary thrombophilia. Acta Haematol . 2004;112(4):209-211.
6.
Sherer Y., Salomon O., Livneh A., Pras M., Langevitz P.Thromboembolism in a patient with transient eosinophilia and thrombocytopenia . Clin Lab Haematol. 2000;22(4):247-249.
Lim SH, Tan CE, Agasthian T., Chew LSAcquired platelet dysfunction with eosinophilia: review of seven adult cases . J Clin Pathol. 1989;42(9):950-952.
9.
Spry CJF , Davies J., Tay PC, Olsen EGJ , Oakley CM, Goodwin JFClinical features of 15 patients with hypereosinophilic syndrome. Q J Med. 1983;52(4):1-22.
10.
Moosbauer C. , Morgenstern E., Cuvelier SL, Manukyan D., Bidzhekov K., Albrecht S., et al. Eosinophils are a major intravascular location for tissue factor storage and exposure . Blood. 2007;109(3):995-1002.
11.
Slungaard A. , Vercellotti GM, Tran T., Gleich GJ, Key NSEosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease. J Clin Invest. 1993;91(4): 1721-1730.
12.
Fredens K., Dahl R., Venge P. In vitro studies of the interaction between heparin and eosinophil cationic protein . Allergy. 1991;46(1):27-29.
13.
Santoro A., Ferrari G., Zucchelli P.Sensitivity to heparin anticoagulant response in eosinophilic patients . Kidney Int Suppl. 1988;24:S84-5.
14.
Samsoon G., Wood ME, Knight-George AB, Britt RPGeneral anaesthesia and the hypereosinophilic syndrome: severe postoperative complications in two patients. Br J Anaesth. 1992;69(6):653-656.