This article reports a female who presented with bleeding, acquired factor VIII and von Willebrand factor (aFVIII-VWF) deficiency, and central deficiency in the thyroid and adrenal axis (Sheehan’s syndrome). After starting hormone replacement therapy, relief of bleeding manifestations was associated with correction of both FVIII and VWF to normal. This report draws attention to a rare association between the acquired form of von Willebrand disease and hypothyroidism of central origin.
Chadarevian R. , Jublanc C., Bruckert E., et al. Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism . J Endocrinol Invest. 2005;28:398.
2.
Dalton RG, Savidge G., Matthews K., et al. Hypothyroidism as a cause of acquired von Willebrand’s disease. Lancet. 1987;1:1007.
3.
Takahashi H. , Yamada M., Shibata A.Acquired von Willebrand’s disease in hypothyroidism. Thromb Haemost. 1987;58:1095.
4.
Smith SR, Auger MJHypothyroidism and von Willebrand’s disease. Lancet . 1987;1:1314.
5.
MacCallum PK , Rodgers M., Taberner DAAcquired von Willebrand’s disease and hypothryroidism. Lancet. 1987; 1:1315.
6.
Coccia MR, Barnes HVHypothyroidism and acquired von Willebrand disease. J Adolesc Health. 1991;12:152.
7.
Levesque H., Borg JY, Vase M., et al. Acquired von Willebrand’s syndrome associated with decrease of plasminogen activator and its inhibitors during hypothyroidism. Eur J Med. 1993;2:284.
8.
Bruggers CS, McElligott K., Rallison MLAcquired von Willebrand disease in twins with autoimmune hypothyroidism: response to desmopressin and l-thyroxine therapy. J Pediatr . 1994;125:911.
9.
Nitu-Whalley C., Lee CAAcquired von Willebrand syndrome: report of 10 cases and review of the literature. Haemophilia . 1999;5:318.
10.
Michiels J. , Schoyens W., Berneman Z., et al. Acquired von Willebrand syndrome type 1 in hypothyroidism: reversal after treatment with thyroxine. Clin Appl Thrombosis/Hemostasis. 2001;7:113.
11.
Gullu S., Sav H., Kamel N.Effects of levothyroxine treatment on biochemical and hemostasis parameters in patients with hypothyroidism. Eur J Endocrinol. 2005; 152:355.
12.
Squizzato A. , Romualdi E., Büller HR, et al. Thyroid dysfunction and effects on coagulation and fibrinolysis: a systematic review. J Clin Endocrinol Metab. 2007;92:2415.
13.
Setian N., Tanaka CM, Damiani D., et al. Hypopituitarism, deficiency of factors V and VII and von Willebrand factor: an uncommon association. J Pediatr Endocrinol Metab . 2002;15:331.
