PIA1/A2 Polymorphism of the Platelet Glycoprotein Receptor IIb/IIIIa and Its Correlation to Cerebrovascular Diseases: An Appraisal

Abstract

Platelet glycoprotein (GP) IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor. There is considerable controversy regarding the clinical role of the GP IIb/IIIa PIA1/A2 as a risk factor of cerebrovascular diseases. Here, the author performs a summative analysis on the recent previous reports on the GP IIb/IIIa PIA1/A2 and its correlation to cerebrovascular diseases. The metanalysis was performed to assess the correlation between the pattern of GP IIb/IIIa PIA1/A2 polymorphism and cerebrovascular diseases. From available 4 case-control studies, 553 patients and 1059 controls are evaluated. From overall risk estimation, the subjects with PIA2 alleles have 1.18 times higher risk to develop cerebrovascular diseases. According to this analysis, the author proposes that the pattern of GP IIb/IIIa PIA1/A2 polymorphism does not represent a useful marker of increased risk for cerebrovascular diseases. The lack of association between pattern of GP IIb/IIIa PIA1/A2 polymorphism and ethnicity can also be showed in this study.

Keywords

platelet glycoprotein polymorphism cerebrovascular disease

References

Wagner KR , Giles WH , Johnson CJ , et al. Platelet glycoprotein receptor IIIIa polymorphism P1A2 and ischemic stroke risk: the stroke prevention in young women study. Stroke. 1998;29:581-585.

Sakariassen KS , Barstad RM Mechanisms of thromboembolism at arterial PIAques. Thromb Res. 2002;108: 63-65.

Kereiakes DJ Preferential benefit of PIAtelet glycoprotein IIb/IIIIa receptor blockade: specific considerations by device and disease state. Am J Cardiol. 1998;81:49E-54E.

van Goor ML , Gomez Garcia E. , Brouwers GJ , Leebeek FW , Koudstaal PJ , Dippel DW PIA1/A2 polymorphism of the PIAtelet glycoprotein receptor IIb/IIIIa in young patients with cryptogenic TIA or ischemic stroke. Thromb Res . 2002;108:63-65.

Pongracz E. , Tordai A. , Csornai M. , Nagy Z. Platelet glycoprotein IIb/IIIa (LeuPro 33) polymorphism in stroke patients . Orv Hetil. 2001;142:781-785.

Ridker PM , Hennekens CH , Schmitz C. , Stampfer MJ , Lindpaintner K. PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet. 1997;349:385-388.

Cole VJ , Staton JM , Eikelboom JW , et al. Collagen platelet receptor polymorphisms integrin alpha2beta1 C807T and GPVI Q317L and risk of ischemic stroke. J Thromb Haemost. 2003;1:963-970.