State-of-the-Art Review : G to A 20210 Prothrombin Polymorphism and Venous Thrombosis: Simple Association or Causal Relationship?

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Girolami A. , Simioni P. , Manfrin A. , et al. Asymptomatic homozygous nt 20210 G to A prothrombin polymorphism in two blood donors belonging to two different kindreds. Clin Appl Thromb Hemost 1999;5:48.

Girolami A. , Simioni P. , Tormene D. , et al. Two additional homozygous patients for the 20210 prothrombin polymorphism with no venous thrombosis. Thromb Res 1999;96:415.

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Howard TE , Marusa M. , Channel C. , et al. A patient homozygous for a mutation in the prothrombin gene 3'-untranslated region associated with massive thrombosis. Blood Coagul Fibrinolysis 1997;8:316.

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Kyrle PA , Mannhalter C. , Beguin S. , et al. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene. Arterioscler Thromb Vasc Biol 1998;18:1287.

Ridker PM , Hennekens CH , Miletich JP G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. Circulation 1999; 99:999.

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Halbmayer WM , Kalhis T. , Haushofer A. , et al. Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210 A/A prothrombin mutation and heterozygous 1691 G/A factor V Leiden mutation . Blood Coagul Fibrinolysis 1999;10:297.

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Girolami A. , Zanon E. , Tormene D. , et al. It is not sure yet whether the nt 20210 G to A prothrombin polymorphism represents a cause of familial venous thrombophilia or not. Blood Coagul Fibrinolysis 1999;10:399.

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Girolami A. , Simioni P. , Scarano L. , et al. Prothrombin and the thrombin 20210 G to A polymorphism: their relationship with hypercoagulability and thrombosis . Blood Rev (in press).

Girolami A. , Scarano L. , Girolami B. , et al. Emphasis on congenital conditions predisposing to thrombosis should not make us disregard the importance of acquired factors. Blood Coagul Fibrinolysis 1998;9:659.