Vasodilators, specifically calcium-channel modulators, are currently in widespread use for the treatment of essential hypertension. Several reports of toxicity from immediate-release verapamil have appeared in the literature. We present a case of sustained-release verapamil overdose as a consequence of an attempted suicide. The treatment measures used in a verapamil toxicity are discussed, as well as a review of the current literature on verapamil overdose.
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References
1.
GoenenMColJCompereATreatment of severe verapamil poisoning with combined amrinone-isoproterenol therapy. Am J Cardiol1986; 58: 1142–3.
KozlowskiJHKozlowskiJASchullerD. Poisoning with sustained-release verapamil. Am J Med1988; 85: 127.
5.
HendrenWGSchieberRSGarrettsonLK. Extracorporeal bypass for the treatment of verapamil poisoning. Ann Emerg Med1989; 18: 984–7.
6.
ZaritskyAHorowitzMChernovB. Glucagon antagonism of calcium channel blocker-induced myocardial dysfunction. Crit Care Med1988; 16: 246–51.
7.
WhiteRDGoldsmithRSRodriguezRPlasma ionic calcium levels following injection of chloride, gluconate and gluceptate salts of calcium. J Thorac Cardiovasc Surg1976; 71: 609–13.
8.
HamannSRBlouinRAMcAllisterRG. Clinical pharmacokinetics of verapamil. Clin Pharmacokinet1984; 9: 26–41.
9.
McAllisterRGHamannSRBlouinRA. Pharmacokinetics of calcium entry blockers. Am J Cardiol1985; 65: 30B–40B.
10.
Package insert.Calan SR (verapamil sustained-release). Skokie, IL: Searle and Company, May 1988.
11.
EichelbaumMSomogyiAVonunruhGESimultaneous determination of the intravenous and oral pharmacokinetic parameters of D, L-verapamil using stable isotope-labeled verapamil. Eur J Clin Pharmacol1981; 19: 133–7.
