Monitoring serum concentrations of anticonvulsant drugs has improved substantially the treatment of epilepsy. However, a sound knowledge of the pharmacokinetics of anticonvulsant drugs is necessary when interpreting serum concentration results and considering dosage adjustments of these drugs.
A computer program developed to assist physicians and pharmacists in designing individualized medication regimens for patients with epilepsy is described. The program also can be used as an interactive educational device for medical and clinical pharmacy students.
ReynoldsE.H.Serum levels of anticonvulsant drugs. Interpretation and clinical value. Pharmacol Ther1980; 8: 217–35.
3.
van der KleijnE., SchobbenF., VreeT.B.Clinical pharmacokinetics of antiepileptic drugs. Calculation of individual doses of drugs in the treatment of epileptic patients. Drug Intell Clin Pharm1980; 14: 674–85.
4.
KuttH., PenryJ.K.Usefulness of blood levels of anti-epileptic drugs. Arch Neurol1974; 31: 283–8.
5.
BartelsH.Rational usage of therapeutic drug monitoring in antiepileptic treatment. Eur J Pediatr1980; 133: 193–9.
6.
GuelenP.J.M., van der KleijnE., WoudstraU.Statistical analysis of pharmacokinetic parameters in epileptic patients chronically treated with anti-epileptic drugs. In: SchneiderH., JanzD., Gardner-ThorpeC., MeinardiH., SherwinA.L., eds. Clinical pharmacology of antiepileptic drugs.Berlin: Springer Verlag, 1975: 1–10.
7.
GuelenP.J.M., van der KleijnE.Rational antiepileptic drug therapy.New York: Elsevier/North Holland Biomedical Press, 1978.
8.
MullenP.W.Optimal Phenytoin therapy: a new technique for individualizing dosage. Clin Pharmacol Ther1978; 23: 228–32.
9.
CoeF.L., NortonE., OparilS., TatarA., PullmanT.N.Treatment of hypertension by computer and physician—a prospective controlled study. J Chron Dis1977; 30: 81–92.
10.
GorryG.A., SilvermanH., PaukerS.G.Capturing clinical expertise. A computer program that considers clinical responses to digitalis. Am J Med1978; 64: 452–60.
