Two patients who presented with unusual cutaneous reactions attributed to quinidine are described. One had a diffuse nonpruritic macular rash, and the other had a localized pruritis without cutaneous manifestations. Both resolved upon de-challenge with quinidine. Disopyramide phosphate was substituted for quinidine in both cases, without subsequent problems.
TroutmanWG. Drug-induced skin disorders. In: KnobenJEAndersonPOWantanabeAS, eds. Handbook of clinical drug data. Hamilton, IL: Drug Intelligence Publications, 1978: 68.
2.
RaymondGESaenzRVChandlerC.Drug-induced skin manifestations. US Pharm1978; 3: 44–61.
3.
CohenISJickHCohenSI. Adverse reactions to quinidine in hospitalized patients: Findings based on data from the Boston Collaborative Drug Surveillance Program. Prog Cardiovasc Dis1977; 20: 151–63.
