Interactions of CNS Drugs — Hypnotics and Sedatives

Abstract

The physicochemical properties of the barbiturates and a brief review of microsomal enzyme induction introduces this literature review of the interactions of sedative and hypnotic drugs. Food has been shown to delay absorption of barbiturates; barbiturates, in turn, may interfere with the absorption of griseofulvin, dicumarol, and folic acid. Barbiturate-produced enzyme induction may result in interactions with the oral anticoagulants, the anticonvulsants, vitamin D, bilirubin, digitoxin, doxycycline, and perhaps other drugs. The problem of additive central nervous system depression and the relative lack of documented evidence is considered. Finally, the interactions of nonbarbiturate hypnotics, such as glutethimide, chloral hydrate, and others are reviewed.