A compilation of tartrazine (FD and C No. 5) containing drugs from major pharmaceutical manufacturers in the United States of America appears.
Characteristics of tartrazine, spectrum of its use, incidence of allergic reactions and relationship with other food and drug dyes are discussed, as are the clinical manifestations of such reactions. The importance of coercive tartrazine disclosure, as well as the disclosure of other excipients and additives by the Food and Drug Administration is emphasized.
Get full access to this article
View all access options for this article.
References
1.
The Merck Index, 8th ed., Merck and Co., Inc., Rahway, N. J., 1968, p. 1015.
2.
ChafeeI. H.SettipaneG. A.: Asthma Caused by FD and C Approved Dyes, J. Allergy40: (No.2) 64–72 (Aug) 1967.
JuhlinL.: Urticaria and Asthma Induced by Food and Drug Additives in Patients with Aspirin Hypersensitivity, J. Allergy Clin. Immunol.50: (No. 2) 92–98 (Aug) 1972.
5.
MichaelssonG.JuhlinL.: Urticaria Induced by Preservatives and Dye Additives in Food and Drugs, Brit. J. Derm.88: 525–532 (June) 1973.
6.
FishermanE. W.CohenG. N.: Aspirin and Other Cross-Reacting Small Chemicals in Known Aspirin Intolerant Patients, Ann. Allergy31: 476–484 (Oct.) 1973.
7.
LockeyS. D.: Allergic Reactions Due to FD and C Yellow No. 5, Tartrazine, an Aniline Dye Used as a Coloring and Identifying Agent in Various Steroids, Ann. Allergy17: 719–721 (Sept.-Oct.) 1959.
8.
SamterM.BeersR. F.Jr., Intolerance to Aspirin — Clinical Studies and Consideration of its Pathogenesis, Ann. Intern. Med.68: 975–983 (May) 1968.
9.
Personal Communication, Various Pharmaceutical Manufacturers.
