Epidemiology of Hospital Admissions for Craniosynostosis in Australia: A Population-Based Study

Abstract

Objective

To describe trends, age, and sex-specific patterns of population hospital admissions with a diagnosis of craniosynostosis (CS) in Australia.

Data Source

Population data for hospital separations (in-patient) from public and private hospitals (July 1996-June 2018) were obtained from the publicly available Australian Institute of Health and Welfare (AIHW) National Hospital Morbidity Database.

Main outcome measures

The outcome variables were hospital separation rates (HSR) (number of hospital separations divided by the estimated resident population [ERP] per year) and average length of stay (aLOS) (patient days divided by the number of hospital separations) with a diagnosis of CS. Trends in HSR and aLOS adjusted for age, sex, and type of CS were investigated by negative binomial regression presented as annual percent change (APC).

Results

In 8057 admissions identified, we observed no significant change in the annual trend for HSR for the 22-year period. However, a marginal annual decrease of 1.6% (95% CI: -0.7, -2.4) in the aLOS was identified for the same time period. HSR were higher for males, infants, and single suture synostosis. aLOS was 3.8 days (95% CI: 3.8, 3.9) per visit, longer for syndromic conditions.

Conclusion

There was a minor reduction in the average length of hospital stay for CS over the 22-year period potentially indicative of improved care. Population-level information on hospitalisations for rare craniofacial conditions can inform research, clinical, and surgical practice.

Keywords

hospital admissions craniosynostosis Australia rare disease syndromic conditions total population

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References

Durham

Howie

Cray

. Gene/environment interactions in craniosynostosis: a brief review. Orthod Craniofac Res. 2017;20 Suppl 1(Suppl 1):8–11.

Lee

Hutson

Wray

Chong

Holmes

Greensmith

. Changing epidemiology of nonsyndromic craniosynostosis and revisiting the risk factors. J Craniofac Surg. 2012;23(5):1245–1251.

Junaid

Slack-Smith

Wong

Bourke

Baynam

Calache

Leonard

. Epidemiology of rare craniofacial anomalies: retrospective western Australian population data linkage study. J Pediatr. 2022;241:162–172 e9.

Bruce

Chang

Joyce

Cobb

Maduekwe

Patel

. Age at time of craniosynostosis repair predicts increased complication rate. Cleft Palate Craniofac J. 2018;55(5):649–654.

Pearson

Matava

. Anaesthetic management for craniosynostosis repair in children. BJA Educ. 2016;16(12):410–416.

Mathijssen

IMJ

. Guideline for care of patients With the diagnoses of craniosynostosis: working group on craniosynostosis. J Craniofac Surg. 2015;26(6):1735–1807.

Yan

Abel

Alotaibi

Anderson

Niazi

Weil

Ibrahim

. A systematic review and meta-analysis of endoscopic versus open treatment of craniosynostosis. Part 1: the sagittal suture. J Neurosurg Pediatr. 2018;22(4):352–360.

Australian Institute of Health and Welfare. Health system overview. 2020a. Retrieved from Canberra: https://www.aihw.gov.au/reports/australias-health/health-system-overview

Australian Institute of Health and Welfare. Hospital care. 2020b. Retrieved from Canberra: https://www.aihw.gov.au/reports/australias-health/hospital-care

10.

Kilpatrick

Jacoby

Slack-Smith

. Description of total population hospital admissions for cleft lip and/or palate in Australia. BMC Oral Health. 2015;15:156.

11.

Australian Institute of Health and Welfare. Principal Diagnosis data cubes. 2020c. Retrieved from Canberra: https://www.aihw.gov.au/reports/hospitals/principal-diagnosis-data-cubes

12.

Junaid

Slack-Smith

Wong

Baynam

Calache

Hewitt

Leonard

. Description of total population hospital admissions for treacher Collins syndrome in Australia. Cleft Palate Craniofac J. 2021:10556656211036618.

13.

Bell

Nassar

Turner

Bower

Gillett

McBain

Raynes-Greenow

. Hospitalisations up to adulthood for children born with orofacial clefts. J Paediatr Child Health. 2016;52(4):441–448.

14.

World Health Organization. Chapter XVII Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99). 2020. Retrieved from: https://icd.who.int/browse10/2010/en#/Q80-Q89

15.

ABS.Stat and Australian Bureau of Statistics. Quarterly population Estimates (ERP), by State/Territory, Sex and Age. 2020. Retrieved from; http://stat.data.abs.gov.au/Index.aspx?DataSetCode=ERP_QUARTERLY

16.

Australian Institute of Health and Welfare. Hospital info & downloads, Glossary. 2020d. Retrieved from https://www.aihw.gov.au/reports-data/myhospitals/content/glossary

17.

Australian Institute of Health and Family Welfare. Australia’s hospitals at a glance 2018–19. 2020e. Retrieved from Canberra: https://www.aihw.gov.au/reports/hospitals/australias-hospitals-at-a-glance-2018-19

18.

Glasson

Wong

Leonard

Forbes

Ravikumara

Mews

Downs

. Evolving trends of gastrostomy insertion within a pediatric population. J Pediatr Gastroenterol Nutr. 2018;67(5):e89–e94.

19.

Australian Institute of Health and Welfare. Data quality statement: National Hospital Morbidity Database 2014–15 . 2016. Retrieved from https://meteor.aihw.gov.au/content/index.phtml/itemId/638202

20.

Australian Institute of Health and Welfare. Procedures data cubes. 2020f. Retrieved from Canberra: https://www.aihw.gov.au/reports/hospitals/procedures-data-cubes

21.

Proctor

. Endoscopic craniosynostosis repair. Transl Pediatr. 2014;3(3):247–258.

22.

Ziaziaris

Marucci

. The management of craniosynostosis in Australia and New Zealand. Australas J Plast Surg [Internet]. 2019;2(1):78–87.

23.

David

Anderson

Flapper

Syme-Grant

Santoreneos

Moore

. Apert syndrome: outcomes From the Australian craniofacial unit’s birth to maturity management protocol. J Craniofac Surg. 2016;27(5):1125–1134.

24.

Massimi

Bianchi

Frassanito

Calandrelli

Tamburrini

Caldarelli

. Imaging in craniosynostosis: when and what? Childs Nerv Syst. 2019;35(11):2055–2069.

25.

Abraham

Brandel

Dalle Ore

Reid

Kpaduwa

Lance

Gosman

. Predictors of postoperative complications of craniosynostosis repair in the national inpatient sample. Ann Plast Surg. 2018;80(5S Suppl 5):S261–S266.

26.

Australian Institute of Health and Welfare. Elective surgery waiting times 2017–18: Australian hospital statistics. Health services series no. 88. Cat. no. HSE 215. Canberra: AIHW; 2018. Retrieved from https://www.aihw.gov.au/getmedia/73b686ab-32e9-48b1-86f2-cd264b3cf073/aihw-hse-215.pdf.aspx?inline=true.

27.

Fearon

McLaughlin

Kolar

. Sagittal craniosynostosis: surgical outcomes and long-term growth. Plast Reconstr Surg. 2006;117(2):532–541.

28.

Esparza

Hinojosa

. Complications in the surgical treatment of craniosynostosis and craniofacial syndromes: apropos of 306 transcranial procedures. Childs Nerv Syst. 2008;24(12):1421–1430.

29.

Lin

Pan

Mayer

Lam

. Complications after craniosynostosis surgery: comparison of the 2012 Kids’ inpatient database and pediatric NSQIP database. Neurosurg Focus. 2015;39(6):E11.

30.

Australian Craniofacial Unit and Women’s and Children’s Hospital. Australian Craniofacial Unit. 2020. Retrieved from; http://www.wch.sa.gov.au/services/az/divisions/psurg/craniofacial/index.html

31.

Rath

Olry

Dhombres

Brandt

Urbero

Ayme

. Representation of rare diseases in health information systems: the orphanet approach to serve a wide range of end users. Hum Mutat. 2012;33(5):803–808.

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