Abstract
Background
Stroke recovery is influenced by genetics, biochemical markers, and rehabilitation. This study examines their combined impact on early upper limb recovery in stroke patients.
Methods
Forty-eight ischemic or hemorrhagic stroke patients were assessed using the Purdue Pegboard Score (PPS) and Fugl-Meyer Assessment (FMA) at admission and discharge. Genetic analysis included selected SNPs (APOE, CRP, PTGS2, IGF1, etc.). Biochemical markers (vitamin B12, folate, homocysteine, cholesterol, and vitamin D) were measured. Patients with PPS < 5 received robotic rehabilitation.
Results
No significant link was found between genetic markers and recovery. However, faster recovery was associated with higher vitamin B12, homocysteine, and cholesterol but lower folate levels. Higher initial FMA scores correlated with better outcomes after robotic rehabilitation.
Conclusions
Metabolic markers may have a stronger influence on post-stroke recovery than genetics. Robotic rehabilitation, especially in patients with higher initial FMA scores, may enhance hand function recovery. These findings emphasize the importance of metabolic and rehabilitation strategies in stroke recovery.
Keywords
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Supplementary Material
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