Purpose: This article describes the perceptions of African American nurses regarding the interaction between work—family conflict, job satisfaction, and psychological well-being. Design and methods: A qualitative descriptive design was employed to conduct six focus group sessions with 23 nurses at three universities in the southeastern United States. Findings: Stressors such as racism or lack of teamwork and supervisor support caused the nurses to contemplate leaving a workplace or the profession. Family stressors, such as an ill family member, also influenced any decision regarding career longevity. Implications: Future studies examining work—family interface, especially positive spillover and psychological well-being are warranted.