To describe a case of leucine-rich, glioma inactivated 1 antibody-encephalitis presenting with psychosis.
Methods:
Case report.
Results:
A young man with leucine-rich, glioma inactivated 1-antibody encephalitis initially presented with acute psychotic symptoms, short-term memory loss and faciobrachial dystonic seizures. Magnetic resonance imaging revealed hippocampal lesions. Electroencephalography revealed frontotemporal slowing of background activity.
Conclusion:
Increased awareness of leucine-rich, glioma inactivated 1-antibody encephalitis may promote early recognition and treatment.
LaiMHuijbersMGLancasterEet al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol2010; 9: 776.
MesselmaniMet al. Limbic encephalitis associated with leucine-rich glioma-inactivated 1 antibodies. Ann Saudi Med2015; 35: 76–79.
7.
van ElstLTKlöppelSRauerS.Voltage-gated potassium channel/LGI1 antibody-associated encephalopathy may cause brief psychotic disorder. J Clin Psychiatry2011; 72: 722.
8.
GrausFTitulaerMJBaluRet al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol2016; 15: 391.
9.
VincentABuckleyCSchottJMet al. Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis. Brain: A Journal of Neurology2004; 127: 701.
10.
IraniSRAlexanderSWatersPet al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan’s syndrome and acquired neuromyotonia. Brain: A Journal of Neurology2010; 133: 2734.
11.
ThomasRAAmbalavananARouleauGAet al. Identification of genetic variants ofLGI1andRTN4R(NgR1) linked to schizophrenia that are defective in NgR1–LGI1 signaling. Molecular Genetics & Genomic Medicine2016; 4: 447–456.
BuckleyCOgerJCloverLet al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol2001; 50: 73–78.
14.
NavarroVKasAApartisEet al. Motor cortex and hippocampus are the two main cortical targets in LGI1-antibody encephalitis. Brain: A Journal of Neurology2016; 139: 1079.
15.
FinkeCPrüssHHeineJet al. Evaluation of Cognitive Deficits and Structural Hippocampal Damage in Encephalitis With Leucine-Rich, Glioma-Inactivated 1 Antibodies. Jama Neurology2016; 74: 50–59.
