The prevalence of cervical and anal human papillomavirus (HPV) and risk factors associated with infections were evaluated in a cross-sectional study of 211 adult women in American Samoa. Overall, 53% of women reported ever having a Pap smear. Cervical and anal HPV was detected in 10% and 16% of women, respectively; 4% of women had concurrent cervical and anal HPV. The most common cervical genotypes were HPV 6, HPV 16, and HPV 53. Cutaneous HPV types were detected in 40% of anal infections. Cervical HPV infection was associated with anal HPV (age-adjusted odds ratio = 3.32, 1.10-10.00). After age adjustment, cervical HPV was associated with being unmarried, postsecondary education, hot running water at home, multiple sexual partners, nulliparity, condom use, and other contraceptive methods. In multivariate analyses, only age remained associated with cervical HPV and anal HPV. Cervical and anal HPV was more prevalent among younger women; only anal HPV was detected in older women.
FerlayJBrayFPisaniPParkinDM. GLOBOCAN 2002 Cancer Incidence. Mortality and Prevalence Worldwide. IARC CancerBase No. 5 version 2.0. Lyon, France: IARC Press; 2004.
2.
SmithJSMelendyARanaRKPimentaJM. Age-specific prevalence of infection with human papillomavirus in females: a global review. J Adolesc Health. 2008;43(4 suppl):S5-S25, Se1-Se41.
3.
VaccarellaSFranceschiSHerreroR. Sexual behavior, condom use, and human papillomavirus: pooled analysis of the IARC human papillomavirus prevalence surveys. Cancer Epidemiol Biomarkers Prev. 2006;15:326-233.
4.
ParkinDM. Cancer in developing countries. Cancer Surv. 1994;19-20:519-561.
5.
United States Bureau of the Census. 2000 Census of Population and Housing. Summary Social, Economic, and Housing Characteristics: American Samoa. Washington, DC: US Department of Commerce, Economics and Statistics Administration, Bureau of the Census; 2002.
6.
MishraSILuce-AoeluaPHHubbellFA. Predictors of Papanicolaou smear use among American Samoan women. J Gen Intern Med. 2001;16:320-324.
7.
Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System Survey Data. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2002.
8.
ParkinDMBrayF. Chapter 2: The burden of HPV-related cancers. Vaccine. 2006;24(suppl 3):S3/11-S3/25.
9.
JohnsonLGMadeleineMMNewcomerLMSchwartzSMDalingJR. Anal cancer incidence and survival: the surveillance, epidemiology, and end results experience, 1973-2000. Cancer. 2004;101:281-288.
10.
BrewsterDHBhattiLA. Increasing incidence of squamous cell carcinoma of the anus in Scotland, 1975-2002. Br J Cancer. 2006;95:87-90.
11.
SolomonDDaveyDKurmanR. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002;287:2114-2119.
12.
GravittPEPeytonCLAlessiTQ. Improved amplification of genital human papillomaviruses. J Clin Microbiol. 2000;38:357-361.
13.
GravittPEPeytonCLAppleRJWheelerCM. Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol. 1998;36:3020-3027.
14.
ForslundOLyHHigginsG. Improved detection of cutaneous human papillomavirus DNA by single tube nested ‘hanging droplet’ PCR. J Virol Methods. 2003;110:129-136.
15.
ForslundO. Genetic diversity of cutaneous human papillomaviruses. J Gen Virol. 2007;88:2662-2669.
16.
CastlePE. The evolving definition of carcinogenic human papillomavirus. Infect Agent Cancer. 2009;4:7.
17.
CliffordGMGallusSHerreroR. Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet. 2005;366:991-998.
18.
DunneEFUngerERSternbergM. Prevalence of HPV infection among females in the United States. JAMA. 2007;297:813-819.
19.
HernandezBYMcDuffieKZhuX. Anal human papillomavirus infection in women and its relationship with cervical infection. Cancer Epidemiol Biomarkers Prev. 2005;14:2550-2556.
20.
PaksoyNMontavilleBMcCarthySW. Cancer occurrence in Vanuatu in the South Pacific, 1980-86. Asia Pac J Public Health. 1989;3:231-236.
21.
FranceschiSHerreroRCliffordGM. Variations in the age-specific curves of human papillomavirus prevalence in women worldwide. Int J Cancer. 2006;119:2677-2684.
22.
Centers for Disease Control and Prevention. Youth risk behavior surveillance—United States, 2005. MMWR Morb Mortal Wkly Rep. 2006;55:1-108.
23.
PalefskyJMHollyEARalstonMLDa CostaMGreenblattRM. Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis. 2001;183:383-391.
24.
VuLLeHLuongOTranHNguyenNHongL. Prevalence of cervical human papillomavirus infection among married women in Hanoi, Vietnam, 2010 [published online ahead of print February 28, 2011]. Asia Pac J Public Health. doi:10.1177/1010539510393727.
25.
SchiffmanMCastlePEJeronimoJRodriguezACWacholderS. Human papillomavirus and cervical cancer. Lancet. 2007;370:890-907.
26.
GoodmanMTShvetsovYBMcDuffieK. Acquisition of anal human papillomavirus (HPV) infection in women: the Hawaii HPV Cohort Study. J Infect Dis. 2008;197:957-966.
27.
GoodmanMTShvetsovYBMcDuffieK. Prevalence, acquisition, and clearance of cervical human papillomavirus infection among women with normal cytology: Hawaii Human Papillomavirus Cohort Study. Cancer Res. 2008;68:8813-8824.
28.
ShvetsovYBHernandezBYMcDuffieK. Duration and clearance of anal human papillomavirus (HPV) infection among women: the Hawaii HPV Cohort Study. Clin Infect Dis. 2009;48:536-546.
