The trend of antimicrobial susceptibility of isolated gram-negative bacteria (GNB) causing neonatal sepsis over a span of six years in a tertiary care neonatal unit in eastern India is reported. The GNB microorganism profile had not changed, but the sensitivity to commonly prescribed higher antimicrobial piperacillin and tazobactam (PIP/TZ) (27.7%-11.6%, p = .013), fluoroquinolone (64%-23.3%, p = .001) had significantly declined. The prevalence of multi-drug resistance (MDR) GNB had increased from 40% to 60%. The sensitivity pattern of GNB for various combinations of empirical antimicrobials is also presented.
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