People with systemic lupus erythematosus (SLE) frequently experience psychiatric problems. Some researchers and clinicians presume that these psychiatric problems are a direct manifestation of the disease, while others suggest that psychosocial and environmental factors have greater etiological significance. The majority of the studies addressing these issues in patients with SLE are too methodologically limited to make confident conclusions regarding etiology. More methodologically sound research in this area is needed. This article describes some of the limitations in past research in the areas of sampling, measurement, research design, data analyses and data presentation. Suggestions for improved methodology in future research are offered.
Hochberg MCSystemic lupus erythematosus. Rheum Dis Clin of North Am1990; 16: 617-639.
2.
Parke A., Rothfield NFSystemic lupus erythematosus. In: Katz WA *ed.). Diagnosis and Management of Rheumatic Diseases , 2nd edn. JB Lippencott: Philadelphia, 1988, pp 448-466.
3.
Bourke BECentral nervous system involvement in systemic lupus erythematosus. Are we any further forward? Br J Rheumatol1993; 32: 267-268.
4.
Abel T., Gladman D., Urowitz M.Neuropsychiatric lupus. J Rheumatol1980; 7: 325-333.
5.
Estes D., Christian CLThe natural history of systemic lupus erythematosus by prospective analysis . Medicine (Balt)1971; 50: 85-95.
6.
Grigor R. et al. Systemic lupus erythematosus: a prospective analysis. Ann Rheum Dis1978; 37: 121-128.
Tan EM et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum1982; 25: 1271-1277.
10.
Iverson GLPsychopathology associated with systemic lupus erythematosus: a methodological review of the literature. Semin Arthritis Rheum1993; 22: 242-251.
11.
Iverson GL, Anderson KWThe etiology of psychiatric symptoms in patients with systemic lupus erythematosus . Scand J Rheumatol1994; 23: 277-282.
12.
Clark EC, Bailey AANeurological and psychiatric signs and associations with systemic lupus erythematosus . JAMA1956; 160: 455-457.
13.
Guze SBThe occurrence of psychiatric illness in systemic lupus erythematosus . Am J Psychiatry1967; 123: 1562-1570.
14.
Feinglass EJ et al. Neuropsychiatric manifestations of systemic lupus erythematosus: diagnosis, clinical spectrum and relationships to other features of the disease. Medicine1976; 55: 323-339.
15.
Bresnihan B. et al. The neuropsychiatric disorder in systemic lupus erythematosus: evidence for both vascular and immune mechanisms. Ann Rheum Dis1979; 38: 301-306.
16.
Baker M. et al. Psychopathology in systemic lupus erythematosus. II. Relation to clinical observations, corticosteroid administration and cerebrospinal fluid C4. Semin Arthritis Rheum1973; 3: 111-126.
17.
Allen TW, Glicksman M.Psychologic involvement in systemic lupus erythematosus: a psychometric approach . Clin Rheumatol Practice1986; March/April/May: 64-70.
18.
Hay EM et al. Psychiatric disorder and cognitive impairment in systemic lupus erythematosus. Arthritis Rheum1992; 35: 411-416.
19.
Kremer JM et al. Non-organic, non-psychotic psychopathology (NONPP) in patients with systemic lupus erythematosus. Semin Arthritis Rheum1981; 11: 182-189.
20.
Keppel G. Design and Analysis: A Researchers Handbook, 2nd edn. Prentice Hall: Englewood Cliffs, 1982.
21.
Hochberg MCThe incidence of systemic lupus erythematosus in Baltimore, Maryland, 1970-1977. Arthritis Rheum1985; 28: 80-85.
22.
Fessel WJSystemic lupus erythematosus in the community: incidence, prevalence, outcome and first symptoms; the high prevalence in black women. Arch Intern Med1974; 134: 1027-1035.
23.
Ginzler EM et al. A multicenter study of outcome in systemic lupus erythematosus. I. Entry variables as predictors of prognosis. Arthritis Rheum1982; 25: 601-611.
24.
Esdaile JM et al. The relationship of socioeconomic status to subsequent health status in systemic lupus erythematosus. Arthritis Rheum1988; 31: 423-427.
25.
Lewis DA, Smith RESteroid-induced psychiatric syndromes: a report of 14 cases and a review of the literature. J Affective Disord1983; 5: 319-332.
26.
Krupp LB et al. A study of fatigue in systemic lupus erythematosus. J Rheumatol1990; 17: 1450-1452.
27.
Borg WR, Gall MDEducational Research: an Introduction, 5th edn. Longman: New York, 1989.
28.
Engle EW et al. Learned helplessness in systemic lupus erythematosus: analysis using the Rheumatology Attitudes Index. Arthritis Rheum1990; 33: 281-286.
29.
Barlow DH, Hersen M.Single Case Experimental Designs. New York: Pergamon, 1984.
