Clinical, haematological and biochemical studies of 34 subjects, occupationally exposed to different types of pesticides, were conducted. The findings have been compared with those observed in 14 control subjects. Inhibition of cholinesterase activity was observed in the exposed group. Serum alkaline phosphatase was also found to be raised. Radiological examination revealed pneumonitic patches in the chest skiagrams of three exposed subjects. Paraesthesia with hyporeflexia was also found in 8.8% of exposed subjects. The findings suggest that exposure to multiple pesticides over many years affects the normal functioning of different organ systems and may produce characteristic clinical effects.
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References
1.
Dacie JV & Lewis SNPractical Haematology. Edinburgh: Churchill-Livingstone, 1975.
2.
Hestrin S.The reaction of acetyl choline and other carboxylic acid derivatives with hydroxylamines and its analytical application.Journal of Biological Chemistry1949; 180: 249-61.
3.
Bessey OA, Lowry OH & Brook MJA method for rapid determination of alkaline phosphatase. Journal of Biological Chemistry1946; 164: 321-9.
4.
Callaway S., Davies DR & Rutland JPBlood cholinesterase levels and range of personal variation in a healthy adult population. British Medical Journal1951; 2: 812-16.
5.
Ngatia J. & Mgeni AYField Worker Exposure During Pesticide Application. Amsterdam : Elsevier, 1980.
6.
Mishra UK, Nag D., Bhushan V. & Ray PKClinical and biochemical changes in chronically exposed organophosphate workers . Toxicology Letters1985; 24: 187-93.
7.
Baker EL, Zack M., Miles JW et al. Epidemic malathion poisoning in Pakistan malaria workers. Lancet1978; 1: 31-4.
Kashyap SK & Gupta SKThe effect of occupational exposure to organophosphorus pesticides on blood cholinesterase. Indian Journal of Medical Research1971; 59: 289-93.
10.
Anonymous.Report of the Plant Protection, Quarentine and Storage. Ministry of Agriculture, Government of India, 1971.
11.
" Nioh.Annual report. National Institute of Occupational Health, Ahmedabad, 1978.
12.
Kubde SS, Pathak MC & Majumdar RDA study of occupational exposure to pesticides on the health of workers. Indian Journal of Industrial Medicine1987; 33: 16-20.
13.
Vorhaus LJ & Kark RMSerum cholinesterase in health and disease. American Journal of Medicine1953; 14: 707-9.
14.
Kagan YSPrinciples of Pesticide Toxicology. Centre for International Projects. Moscow: GKNT, 1985.
15.
Despotov Z.1967 (cited in) Kagan YSPrinciples of Pesticide Toxicology. Centre for International Projects. Moscow: GKNT, 1985.
16.
Karimov TL1969 (cited in) Kagan YSPrinciples of Pesticide Toxicology. Centre for International Projects. Moscow: GKNT, 1985.
17.
Leliukh VM & Maluink VIPesticide use: Hygiene, Toxicology and Clinical Features of Poisoning, pp. 330-4. Kiev: Zdorovie, 1966.
18.
Mundhata GB & Gharpure JMToxicity studies in pesticides industrial workers. Indian Journal ofIndustrial Medicine1979; 25: 285-91.
19.
Jeyaratnam J. & Ponnabalam N.Monitoring of public health workers exposed to fenthion. In: Field Worker Exposure During Pesticide Application, eds Tordoir WF & Van Heernstra EAH.Amsterdam: Elsevier, 1980.
20.
Key K., Monkman L., Windish JP et al. Parathion exposure and cholinesterase response of Quebec apple growers. Archives of Industrial Hygiene and Occupational Medicine1952; 6: 252-62.
21.
Gupta RC, Dave SK, Shah MP & Kashyap SKA monitoring study of workers handling pesticides in warehouses and godowns . Journal Environmental Sciences and Health1979; 14: 31-4.
22.
Siddiqui Mkj , Saxena MC, Mishra UK, Krishna Murti CR & Nag D.Long-term exposure to DDT. International Archives of Occupational Environmental Health1981; 48: 301-8.
23.
Misra UK, Nag D. & Krishna Murti CRA study of cognitive functions in DDT sprayers. IndustrialHealth1984; 22: 199-206.
