Abstract
1 Six healthy volunteers took part in a 2-week haemodynamic safety study of astemizole.
2 They were given 30 mg daily (3 x 10 mg tablets) for the first 3 days and 10 mg daily for the next 12 consecutive days.
3 Heart rate, blood pressure, ECG and systolic time intervals at rest were measured before the start and five times during the day.
4 No changes were observed in any of the parameters measured. The configuration of the ECG was not influenced.
5 Serum concentrations of astemizole plus hydroxylated metabolites measured at the end of the study were 16 times lower than those detected in a patient overdosing on 200 mg astemizole.
Get full access to this article
View all access options for this article.