Cerebrospinal fluid (CSF) escape phenomenon is widely studied and documented in HIV-1. However, hardly anything is known about progressive neurologic disease in otherwise well-controlled HIV-2 infection. We present a case of neurosymptomatic CSF escape in HIV-2 infection from India.
FerrettiFGisslenMCinquePet al.
Cerebrospinal fluid HIV escape from antiretroviral therapy. Curr HIV/AIDS Rep2015;
12: 280–288.
2.
PelusoMJFerrettiFPetersonJet al.
Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load. AIDS2012;
26: 1765–1774.
3.
de SilvaT andWeissRA.HIV-2 goes global: an unaddressed issue in Indian anti-retroviral programmes. Indian J Med Res2010;
132: 660–662.
4.
MornerAThomasJABjorlingEet al.
Productive HIV-2 infection in the brain is restricted to macrophages/microglia. AIDS2003;
17: 1451–1455.
5.
WoodBRKleinJPLyonsJLet al.
HIV-2 encephalitis: case report and literature review. AIDS Patient Care STDS2012;
26: 383–387.
6.
JoakimEFredrikMAndersKet al. High rate of disease progression in untreated HIV-2 infection. In: Conference on retroviruses and opportunistic infections, 13–16 February 2017, Seattle, Washington.
7.
JaffarSGrantADWhitworthJet al.
The natural history of HIV-1 and HIV-2 infections in adults in Africa: a literature review. Bull World Health Organ2004;
82: 462–469.
8.
KhouryMNTanCSPeasleeMet al.
CSF viral escape in a patient with HIV-associated neurocognitive disorder. J Neurovirol2013;
19: 402–405.
9.
HammondERCrumRMTreismanGJet al.
The cerebrospinal fluid HIV risk score for assessing central nervous system activity in persons with HIV. Am J Epidemiol2014;
180: 297–307.
10.
LetendreS.Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder. Top Antivir Med2011;
19: 137–142.
