Prevalence of HIV-2 Infection in a Family Planning Clinic in Lisbon

Abstract

A significant proportion (10%) of notified AIDS cases in Portugal are due to HIV-2 infection as a result of the close connections of Portugal with Western African Countries (ex-Portuguese colonies) where there is a high HIV-2 seroprevalence.

We conducted a seroepidemiological study of HIV-1 and HIV-2 infection in 1400 women attending family planning and antenatal clinics in a health centre in Lisbon with the objective of analysing whether there was evidence of HIV-2 spread in this population. The seroprevalence for HIV, as determined by ELISA and confirmed by Western Blot, was 0.42% (6 cases) and 50% of these were of HIV-2 infection. Analysis of the epidemiological inquiries reveals that out of the 6 seropositive cases, only one was a drug addict (HIV-1) and another a western African black woman (HIV-2). The other 4 cases (2 HIV-2 and 2 HIV-1) were white Portuguese women with no history of travelling to Africa or previous blood transfusions, and the only risk factor was a history of multiple sexual partners (in 3 out of 4).

Keywords

HIV-2 infection HIV-2 seroepidemiology Portugal women family planning

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References

Gallo

Salahuddin

Popovic

. Frequent detection and isolation of cytopathic retrovirus (HTLV III) from patients with AIDS and at risk for AIDS. Science 1984; 224: 497–500

Clavel

Mansinho

Chamaret

. Human immunodeficiency virus type 2 infection associated with AIDS in West Africa. N Engl J Med 1987; 316: 1180–5

Clavel

Guetard

Beun-Vezinet

. Isolation of a new human retrovirus from West-African patients with AIDS. Science 1986; 233: 343–6

Kanki

Barin

M'Boup

. New human T-lymphotropic virus related to simian T-lymphotropic virus type III (STLV III_AGM). Science 1986; 232: 238–43

Smallman

Cliff

The spread of human immunodeficiency virus type 2 into Europe: A geographical analysis. Int J Epidemiol 1991; 20: 480–9

Centers for Disease Control. Update: HIV2 infection—United States. MMWR 1989; 38: 572–80

Lee

Moudgil

Kerndt

. HIV2 in Los Angeles. AIDS 1991; 4: 1301–2

Aires

Costa

Champalimaud

Caetano

Ribeiro

. Document 53-AIDS situation in Portugal in June 1991. National Committee against AIDS. Lisbon: Center for Epidemiologic Surveillance of Infectious Diseases, 1991.

Stoneburner

Chiasson

Weisfuse

Thomas

. The epidemic of AIDS and HIV1 infection among heterosexuals in New York City. AIDS 1990; 4: 99–106

10.

Holf

Berardi

Wildein

Mahoney-Trout

Mitchell

Crady

. Seroprevalence of human immunodeficiency virus among childbearing women. N Engl J Med 1988; 318: 525–30

11.

Telles

Guerreiro

Lourenço

Ferreira

MOS

Victorino

RMM

. Analysis of the seroprevalence of HIV1 and HIV2 infection in women living in an area of the city of Lisbon. Acta Med Port 1991; 4: 64–70

12.

Le Guenno

HIV1 and HIV2: Two ancient viruses for a new disease. Trans R Soc Trop Med Hyg 1989; 83: 847

13.

Bryceson

Tomkins

Ridley

. HIV2 associated AIDS in the 1970s. Lancet 1988; ii: 22

14.

Victorino

RMM

Maria

Ferreira

Lourenço

. IV International Conference on AIDS. Abstract Book N.2, 5535. Stockholm, 1988

15.

Ancelle

Bletry

Baglin

Brun-Vezinet

Rey

Godeau

Long incubation period for HIV-2 infection. Lancet 1987; i: 688–99

16.

Gody

Ouattara

de Thé

Clinical experience of AIDS in relation with HIV-1 and HIV-2 infection in a rural hospital in Ivory Coast, West Africa. AIDS 1988; 2: 433–6

17.

Pepin

Morgan

Dunn

. HIV2 induced immunosuppressor among asymptomatic West African prostitutes: Evidence that HIV2 is pathogenic but less so than HIV1. AIDS 1991; 10: 1165–72

18.

Kourouma Foucault-Fretz

Diallo

. HIV1 and HIV2 seropositivity among AIDS cases in Guinea. AIDS 1990; 4: 1299–300