The natural polymer-containing nanocomposite (Ag-Ag2O-TiO2@Eggshell membrane protein) was prepared using a rapid and efficient one-pot method. Diagnosis of this nanostructure was performed by X-ray diffraction, Energy dispersive X-ray, and SEM. The characterization results proved that this multifunctional nanocomposite was successfully synthesized within the scale of nanoscience. The conductivity of this polymer was studied in the presence of sodium iodide using acetonitrile as a solvent by complex impedance spectroscopy. The conductivity measurements prove that the highest conductivity was obtained with the highest salt concentration 1:5=Na:O. Furthermore, Ag-Ag2O-TiO2@Eggshell membrane protein nanocomposite was used to study its ability for healing the wound infected with antibiotic-resistant Staphylococcus aureus for 2 weeks. The histopathological results have shown that there is an improvement in all the indicative signs of disease with rapid development of the epidermal layer proliferating and then healing of the infected wounds rapidly.
MoreillonPQueYGlauserMP. Staphylococcus aureus. In: Principles and practice of infectious disease. Philadelphia, PA: Elsevier-Churchill Livingstone, 2005, pp. 2321–2351.
2.
PidwillGRGibsonJFColeJ, et al.The role of macrophages in Staphylococcus aureus infection. Front Immunol2021; 11: 3506.
3.
AqibAISaqibMKhanSR, et al.Non-steroidal anti-inflammatory drugs, plant extracts, and characterized microparticles to modulate antimicrobial resistance of epidemic mecA positive S. aureus of dairy origin. Appl Nanosci2021; 11(2): 553–563.
4.
QianYAltamimiAYatesSA, et al.H2S-releasing amphiphilic dipeptide hydrogels are potentS. aureusbiofilm disruptors. Biomater Sci2020; 8(9): 2564–2576.
O'GaraJP. Into the storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life-threatening infections. Environ Microbiol2017; 19(10): 3823–3833.
9.
WuYNieYHuangJ, et al.Protostemonine alleviates heat-killed methicillin-resistant Staphylococcus aureus-induced acute lung injury through MAPK and NF-κB signaling pathways. Int Immunopharmacol2019; 77: 105964.
10.
ZapfRLWiemelsREKeoghRA, et al.The small RNA Teg41 regulates expression of the alpha phenol-soluble modulins and is required for virulence in Staphylococcus aureus. MBio2019; 10(1): e02484.
11.
NonfouxLChiaruzziMBadiouC, et al.Impact of currently marketed tampons and menstrual cups on Staphylococcus aureus growth and toxic shock syndrome toxin 1 production in vitro. Appl Environ Microbiol2018; 84(12): e00351.
12.
PengLJiangJChenT, et al.Toxic shock syndrome toxin 1 induces immune response via the activation of NLRP3 inflammasome. Toxins2021; 13(1): 68.
13.
GillespieSHawkeyPM (eds). Principles and practice of clinical bacteriology. Germany: John Wiley & Sons, 2006.
14.
AlheetyMAAl-JiboriSAAliAH, et al.Ag(I)-benzisothiazolinone complex: synthesis, characterization, H2 storage ability, nano transformation to different Ag nanostructures and Ag nanoflakes antimicrobial activity. Mater Res Exp2019; 6(12): 125071.
15.
AlheetyMAHameedAA. Synthesis, characterization and antifungal activity of coated silver nanoparticles-nystatin and coated silver nanoparticles-clotrimazol. Tikrit J Pure Sci2018; 23(7): 63–70.
16.
AlheetyNFHamadMAKalifAZ, et al.Biogenic silver nanowires for hybrid silver functionalized benzothiazolilthiomethanol as a novel organic-inorganic nanohybrid. Mater Today Proc2021; 43: 2076–2082.
17.
SalihBDAliAHAlheetyMA, et al.Biosynthesis of Ag nanospheres using waste phoenix dactylifera argonne: a prospective anticancer and antibacterial. Mater Res Exp2019; 6(10): 105063.
18.
VanlalveniCLallianrawnaSBiswasA, et al.Green synthesis of silver nanoparticles using plant extracts and their antimicrobial activities: a review of recent literature. RSC Adv2021; 11(5): 2804–2837.
19.
AlheetyNFMajeedAHAlheetyMA. Silver nanoparticles anchored 5-methoxy benzimidazol thiomethanol (MBITM): Modulate, characterization and comparative studies on MBITM and Ag-MBITM antibacterial activities. J Phy Conf Series2019; 1294: 052026.
20.
MajeedAHHussainDHAl-TikrityETB, et al.Poly (o-Phenylenediamine-GO-TiO2) nanocomposite: modulation, characterization and thermodynamic calculations on its H2 storage capacity. Chem Data Collect2020; 28: 100450.
21.
TsaiWTYangJMLaiCW, et al.Characterization and adsorption properties of eggshells and eggshell membrane. Bioresour Technol2006; 97(3): 488–493.
22.
LuSHummelMGuZ, et al.Highly efficient urea oxidation via nesting nano-nickel oxide in eggshell membrane-derived carbon. ACS Sustain Chem Eng2021; 9(4): 1703–1713.
23.
GirelliAMScutoFR. Eggshell membrane as feedstock in enzyme immobilization. J Biotechnol2021; 325: 241–249.
24.
ZhangYChenYKangZ-W, et al.Waste eggshell membrane-assisted synthesis of magnetic CuFe2O4 nanomaterials with multifunctional properties (adsorptive, catalytic, antibacterial) for water remediation. Colloids Surf A Physicochem Eng Aspects2021; 612: 125874.
25.
AlheetyMARaoofAAl-JiboriSA, et al.Eco-friendly C60-SESMP-Fe3O4 inorganic magnetizable nanocomposite as high-performance adsorbent for magnetic removal of arsenic from crude oil and water samples. Mater Chem Phys2019; 231: 292–300.
26.
ShahAHaqSRehmanW, et al.Photocatalytic and antibacterial activities of paeonia emodi mediated silver oxide nanoparticles. Mater Res Express2019; 6(4): 045045.
27.
WuYGaoFWangH, et al.Probing acid-base properties of anatase TiO2 nanoparticles with dominant {001} and {101} facets using methanol chemisorption and surface reactions. J Phys Chem C2021; 125(7): 3988–4000.
28.
HerathHMASeneviratneVA. Electrical and Thermal studies on Sodium based polymer electrolyte. Proced Engg2017; 215: 124–129.
