Multifunctional nanocarriers have been widely accepted and utilized for biomedical applications, because of their structural regularity, convenient post-modification and controllable structure and morphology. Herein, we reported polydopamine-doped virus-like mesoporous silica coated reduced graphene oxide nanosheets (rGO@PVMSNs) nanocomposites by a facile oil–water biphase stratification method. The synthesized rGO@PVMSNs nanocomposites performed excellent biocompatibility and photothermal performance. They could be employed as photoacoustic imaging contrast in vivo. Furthermore, the rGO@PVMSNs nanocarriers were used for loading the antitumor drug doxorubicin (DOX), the rGO@PVMSNs@DOX nanocomposites were also demonstrated to be with high inhibition of HepG2 cancer cells, especially with the help of near-infrared irradiation, which were more efficient than single chemotherapy or photothermal therapy. The rGO@PVMSNs@DOX nanocomposites of this work could be used as photoacoustic imaging and chemo-photothermal synergetic therapy agents, which show a new perspective for clinical tumor diagnosis and therapy.
KimHHwangDBChoiM, et al.
Antibody-assisted delivery of a peptide–drug conjugate for targeted cancer therapy. Mol Pharm2018;
69: 191–207.
2.
ZhongZSanchez-LopezEKarinM.Autophagy, inflammation, and immunity: a Troika governing cancer and its treatment. Cell2016;
166: 288–298.
3.
LeiYTangLXieY, et al.
Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer. Nat Comm2017;
8: 1530.
4.
ZhangPHuCRanW, et al.
Recent progress in light-triggered nanotheranostics for cancer treatment. Theranostics2016;
6: 948–968.
5.
XiaoYTLiuJChenCY, et al.
Synergistic combination chemotherapy using carrier-free celastrol and doxorubicin nanocrystals for overcoming drug resistance. Nanoscale2018;
10: 12639–12649.
6.
WangCChenSQWangYX, et al.
Lipase-triggered water-responsive “Pandora’s Box” for cancer therapy: toward induced neighboring effect and enhanced drug penetration. Adv Mater2018;
30: 1706407.
7.
ChenQXuLLiangC, et al.
Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Comm2016;
7: 13193.
8.
LiuYBhattaraiPDaiZ, et al.
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem Soc Rev2019;
48: 2053–2108.
9.
LiZShaoJLuoQ, et al.
Cell-borne 2D nanomaterials for efficient cancer targeting and photothermal therapy. Biomaterials2017;
133: 37–48.
10.
WangXLiuHChenD, et al.
Multifunctional Fe3O4@P(St/MAA)@chitosan@Au core/shell nanoparticles for dual imaging and photothermal therapy. ACS Appl Mater Interfaces2013;
5: 4966–4971.
11.
YangXWangDShiY, et al.
Black phosphorus nanosheets immobilizing Ce6 for imaging-guided photothermal/photodynamic cancer therapy. ACS Appl Mater Interfaces2018;
10: 12431–12440.
12.
NamJSonSOchylLJ, et al.
Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer. Nat Comm2018;
9: 1074.
13.
ZouLWangHHeB, et al.
Current approaches of photothermal therapy in treating cancer metastasis with nanotherapeutics. Theranostics2016;
6: 762–772.
14.
YaoJLiuYWangJ, et al.
On-demand CO release for amplification of chemotherapy by MOF functionalized magnetic carbon nanoparticles with NIR irradiation. Biomaterials2019;
195: 51–62.
15.
AliMRKAliHRRankinCR, et al.
Targeting heat shock protein 70 using gold nanorods enhances cancer cell apoptosis in low dose plasmonic photothermal therapy. Biomaterials2016;
102: 1–8.
16.
YangLTsengY-TSuoG, et al.
Photothermal therapeutic response of cancer cells to aptamer–gold nanoparticle-hybridized graphene oxide under NIR illumination. ACS Appl Mater Interfaces2015;
7: 5097–5106.
17.
ChenY-WSuY-LHuS-H, et al.
Functionalized graphene nanocomposites for enhancing photothermal therapy in tumor treatment. Adv Drug Deliv Rev2016;
105: 190–204.
ComptonOCKimSPierreC, et al.
Crumpled graphene nanosheets as highly effective barrier property enhancers. Adv Mater2010;
22: 4759–4763.
20.
WangXYinRZengL, et al.
A review of graphene-based nanomaterials for removal of antibiotics from aqueous environments. Environ Pollut2019;
253: 100–110.
21.
BaoHPanYPingY, et al.
Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small2011;
7: 1569–1578.
22.
ZhangLXiaJZhaoQ, et al.
Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs. Small2010;
6: 537–544.
23.
YangXZhangXMaY, et al.
Superparamagnetic graphene oxide–Fe3O4 nanoparticles hybrid for controlled targeted drug carriers. J Mater Chem2009;
19: 2710–2714.
24.
ShiSChenFEhlerdingEB, et al.
Surface engineering of graphene-based nanomaterials for biomedical applications. Bioconjug Chem2014;
25: 1609–1619.
25.
ZhangHWuHWangJ, et al.
Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. Biomaterials2015;
42: 66–77.
26.
KalluruPVankayalaRChiangCS, et al.
Nano-graphene oxide-mediated In vivo fluorescence imaging and bimodal photodynamic and photothermal destruction of tumors. Biomaterials2016;
95: 1–10.
27.
ZhangDYZhengYTanCP, et al.
Graphene oxide decorated with Ru(II)-polyethylene glycol complex for lysosome-targeted imaging and photodynamic/photothermal therapy. ACS Appl Mater Interfaces2017;
9: 6761–6771.
28.
GaoSZhangLWangG, et al.
Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy. Biomaterials2016;
79: 36–45.
29.
WangWWangPTangX, et al.
Facile synthesis of uniform virus-like mesoporous silica nanoparticles for enhanced cellular internalization. ACS Cent Sci2017;
3: 839–846.
30.
LiuYAiKLuL.Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields. Chem Rev2014;
114: 5057–5115.
31.
BatulRTamannaTKhaliqA, et al.
Recent progress in the biomedical applications of polydopamine nanostructures. Biomater Sci2017;
5: 1204–1229.
32.
LiYJiangCZhangD, et al.
Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. Acta Biomater2017;
47: 124–134.
33.
PoinardBNeoSZYYeoELL, et al.
Polydopamine nanoparticles enhance drug release for combined photodynamic and photothermal therapy. ACS Appl Mater Interfaces2018;
10: 21125–21136.
34.
LiDZhangYWenS, et al.
Construction of polydopamine-coated gold nanostars for CT imaging and enhanced photothermal therapy of tumors: an innovative theranostic strategy. J Mater Chem B2016;
4: 4216–4226.
35.
DongZGongHGaoM, et al.
Polydopamine nanoparticles as a versatile molecular loading platform to enable imaging-guided cancer combination therapy. Theranostics2016;
6: 1031–1042.
36.
ZhangHWangXWangP, et al.
One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy. RSC Adv2018;
8: 37433–37440.
37.
LiHCuiYSuiJ, et al.
Efficient delivery of DOX to nuclei of hepatic carcinoma cells in the subcutaneous tumor model using pH-sensitive pullulan-DOX conjugates. ACS Appl Mater Interfaces2015;
7: 15855–15865.
38.
HummersWSOffemanRE.Preparation of graphitic oxide. J Am Chem Soc1958;
80: 1339.
39.
AlamSNSharmaNKumarL.Synthesis of graphene oxide (GO) by modified hummers method and its thermal reduction to obtain reduced graphene oxide (rGO). Graphene2017;
6: 1–18.
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
