Curcumin-loaded poly(l-lactide- co -D,l-lactide) electrospun fibers: Preparation and antioxidant,anticoagulant,and antibacterial properties

Abstract

Fibrous materials of poly(l-lactide-co-d,l-lactide), poly(l-lactide-co-d,l-lactide)/poly(ethylene glycol), and curcumin were prepared by electrospinning. The incorporation of poly(ethylene glycol) in the fibers caused a decrease in the mean fiber diameters down to 700 nm and in the water contact angle value, the latter being equal to 0 at poly(l-lactide-co-d,l-lactide)/poly(ethylene glycol) 60/40 weight ratio. The water contact angle values of poly(l-lactide-co-d,l-lactide)/curcumin fibrous materials considerably exceeded those of films of the same composition (approximately 120° as compared to approximately 95°, for electrospun mats and solution-cast films, respectively). Curcumin affected the thermal stability of the fibrous materials and the crystallinity degree of the polymers. The mechanical properties of the electrospun materials also depended on the composition of the polymer matrix and the amount of curcumin therein. In the curcumin-containing fibers, curcumin was found in the amorphous state, while higher antioxidant activity was exhibited by poly(l-lactide-co-d,l-lactide)/poly(ethylene glycol)/curcumin fibrous materials. In vitro determination of the activated partial thromboplastin time and prothrombin time showed that poly(l-lactide-co-d,l-lactide)/curcumin fibrous materials displayed anticoagulant activity. Antibacterial effect toward Staphylococcus aureus was manifested by the curcumin-containing mats.