Sage Journals: Discover world-class research

Abstract

A new microwave-assisted method was used to prepare magnetic Fe₃ O₄ particles and magnetic bovine albumin microspheres. The microwave method produced smaller particles and is faster than traditional methods. The optimum conditions to prepare the Fe₃O₄ particles were three minutes at pH 13 and 80°C. Magnetic microspheres containing albumin were synthesized based on heating times and temperatures to form microspheres with different properties. For example, heating for 4min, at 160°C, yielded smaller sized microspheres (30 μm). Confirmed by XRD, SEM, and FT-IR that iron oxide particles were encapsulated in biocompatible proteins, The thermal stability of the microspheres were determined by DSC and TG. The magnetic properties were determined by UV—VIS spectraphotometry and a Guoy magnetic balance. This microwave process could become a preferred method for the synthesis of magnetized protein microspheres.

Keywords

microwave-assisted method magnetic Fe3O4 particles magnetic albumin microspheres magnetic microsphere preparation magnetic microsphere characterization.

Get full access to this article

View all access options for this article.

References

Zhu, J.F. and Zhu, Y.J. (2006). Microwave-Assisted One-Step Synthesis of Polyacrylamide-Metal (M = Ag, Pt, Cu) Nanocomposites in Ethylene Glycol , J. Phys. Chem. B., 110: 8593-8597.

Gass, I.A. , Milios, C.J. , Whittaker, A.G. , Fabiani, F.P.A. , Murrie, S.P.M. and Perlepes, S.P. (2006). A Cube in a Tetrahedron: Microwave-Assisted Synthesis of an Octametallic FeIII Cluster, Inorg . Chem., 45: 5281-5283.

Gronnow, M.J. , White, R.J. , Clark , J.H. and Macquarrie , D.J. (2005). Energy Efficiency in Chemical Reactions: A Comparative Study of Different Reaction Techniques, Org . Process Res. Dev., 9: 516-518.

Ito, A. , Shinkai, M. , Honda, H. and Kobayashi, T. (2005). Medical Application of Functionalized Magnetic Nanoparticles , J. Biosci. Bioeng., 100: 1-11.

Zhou, G.J. , Lu, M.K. , Yang, Z.S. et al. (2007). Fabrication of Novel Palladium Microstructures through Self-Assembly, Cry . Growth & Design, 7: 187-190.

Deng, Y.H. , Yang, W.L. , Wang, C.C. and Fu, S.K. (2003). A novel approach for preparation of Thermoresponsive Polymer Magnetic Microspheres with Core-shell Structure , Adv. Mater., 15: 1729-1732.

Wang, P.H. and Pan, C.Y. (2000). Polymer Metal Composite Microspheres Preparation and Characterization of poly(St-co-AN)Ni Microspheres, Europ . J. Polym., 36: 2297-2300.

Mahkam, M. , Allahverdipoor, M. , Mohammadi, R. , Ranaei-Siadat, S.O. , Rashidi, M.R. , Davaran, S. , Barshan, M. and Ranaei-Siadat, S.E. (2006). An Oral Delivery System for Insulin , J. Bioact. Compat. Polym., 21: 135-148.

Zhao, L. , Mitomo, H. and Yosh, F. (2008). Synthesis of pH-Sensitive and Biodegradable CM-Cellulose/Chitosan Polyampholytic Hydrogels with Electron Beam Irradiation , J. Bioact. Compat. Polym., 23: 319-333.

10.

Sweitzer, R. , Scholz, C. , Montezuma , S. and Rizzo, J.F., III , (2006). Evaluation of Subretinal Implants Coated with Amorphous Aluminum Oxide and Diamond-like Carbon , J. Bioact. Compat. Polym., 21: 5-22.

11.

Qi, R.J. and Zhu, Y.J. (2006). Microwave-assisted Synthesis of Calcium Carbonate (vaterite) of Various Morphologies in Water-ethylene Glycol Mixed Solvents , J. Phys. Chem. B., 110: 8302-8306.

12.

Berthold, A. , Cremer, K. and Kreuter, J. (1996). Preparation and Characterization of Chitosan Microspheres as Drug Carrier for Prednisolone Sodium Phosphate as Model for Anti-inflammatory Drugs , J. Control led Release , 17: 39-41.

13.

Madhan Kumar, A.B. and Panduranga Rao, K. (1998). Preparation and Characterization of pH-Sensitive Proteinoid Microspheres for the Oral Delivery of Methotrexate , Biomaterials, 19: 725-732.

14.

Shantha, K.L. and Harding, D.R.K. (2002). Synthesis and Characterisation of Chemically Modified Chitosan Microspheres, Carbohydr . Polym., 48: 247-253.

15.

Denkbas, E. and Ottenbrite, R.M. (2006). Perspectives on: Chitosan Drug Delivery Systems Based on their Geometries , J. Bioact. Compat. Polym., 21: 351-368.

16.

Klung, H.P. and Alexander, L.E. (1974). X-ray Diffraction Procedures, New York, Wiley Press.

17.

Zhang, J. , Zhang, S. , Wu, G. , Wang, W. , Gao, S. , Zhang, J. et al. (2007). An Investigation of Two Kinds of Magnetic Chitosan Composite Microspheres , J. Bioact. Compat. Polym. , 22: 429-441.

18.

Ma, Y.F. and Ca, J.Y. (2007). Study of Molecular Imprinting Polymer Made of Chitosan and BSA by AFM, Polym . Sci. Eng., 2: 273-241.

Microwave-assisted Preparation of Magnetic Albumin Microspheres

Abstract

Keywords

Get full access to this article

References