The acute lethality of thermal decomposition products of various polymeric materials was investigated using bioassay procedures and a small scale com bustion apparatus. The concentrations of pertinent fire gases individually and in various combinations and the amount of combusted material needed to cause 50% lethality (LC50) during a planned 30 minute exposure and 10 minute recovery period were determined along with the lethal blood cyanide and car boxyhemoglobin (COHb) concentrations. Also, the results of controlled pure gas experiments with CO, HCN, CO2, or low O2 singly or in combination are used in an attempt to explain their role during intoxication by smoke from a variety of polymeric materials, particularly those containing nitrogen and yielding HCN during thermal decomposition. These data gathered in controlled and combustion experiments using mice are compared to toxicological findings in human fire fatalities in an attempt to establish a threshold value for fatal cyanide concentrations in the blood of fire fatalities.
Cullis, C.F. and M.M. Hirschler.The Combustion of Organic Polymers, Oxford:Clarendon Press (1981).
2.
Kaplan, H.L., A.F. Grand and G.E. Hartzell.Combustion Toxicology, Principles and Test Methods , Lancaster, PA:Technomic Publishing (1983).
3.
Alarie, Y. and R.C. Anderson."Toxicologic Classification of Thermal Decomposition Products of Synthetic and Natural Polymers,"Toxicol. Appl. Pharmacol., 57:181-188 (1981).
4.
Alarie, Y. and R.C. Anderson."Toxicologic and Acute Lethal Hazard Evaluation of Thermal Decomposition Products of Synthetic and Natural Polymers,"Toxicol. Appl. Pharmacol., 51:341-362 (1979).
5.
Weil, C.S."Tables for Convenient Calculation of Median-Effective Dose (LD50 or ED50) and Instructions in Their Use,"Biometrics, 8:249-263 (1952).
6.
Paabo, M., M.M. Birky and S.E. Womble."Analysis of Hydrogen Cyanide in Fire Environments,"J of Combustion Toxicology, 6:99-109 (1979).
7.
Feldstein, M. and N. Klendshoj."The Determination of Volatile Substances by Microdiffusion Analysis,"J. of Forensic Science , 2:30 (1957).
8.
Winek, C.L. and D.M. Prex."A Comparative Study of Analytical Methods to Determine Postmortem Changes in Carbon Monoxide Concentration,"Forensic Science International, 18:181-187 (1981).
9.
Matijak-Schaper, M., M.F. Stock and Y. Alarie."Toxicity of Thermal Decomposition Products from Commonly Used Synthetic Polymers,"Fire Sci. and Tech., 1:1-10 (1982).
10.
Herpol, C."Biological Evaluation of the Toxicity of Products of Pyrolysis and Combustion of Materials,"Fire and Materials, 1:29-35 (1976).
11.
Levin, B.C. , M. Paabo, J.L. Gurman and S.E. Harris."Effects of Exposure to Single or Multiple Combinations of the Predominant Toxic Gases and Low Oxygen Atmospheres Produced in Fires,"Fundam. Appl. Toxicol., 9:236-250 (1987).
12.
Stewart, R.D. , J.E. Petersen, T.N. Fisher, M.J. Hosko, E.D. Baretta, H.C. Dodd and A.A. Herrman."Experimental Human Exposure to High Concentrations of Carbon Monoxide,"Arch. Environ. Health, 26:1-7 (1973).
13.
Matijak-Schaper, M. and Y. Alarie."Toxicity of Carbon Monoxide, Hydrogen Cyanide and Low Oxygen,"J. of Combustion Toxicol. , 9:21-61 (1982).
14.
Hartzell, G.E. , D.N. Priest and W.G. Switzer."Modeling of Toxicological Effects of Fire Gases: II. Mathematical Modeling of Intoxication of Rats by Carbon Monoxide and Hydrogen Cyanide,"J. of Fire Sciences , 3:115-128 (1985).
15.
Kimmerle, George."Aspects and Methodology for the Evaluation of Toxicological Parameters During Fire Exposure,"Combustion Toxicology, 1:4-51 (1974).
16.
Baselt, R.C.Disposition of Toxic Drugs and Chemicals in Man, Davis, California:Biomedical Publications ( 1982).
17.
Moffat, A.C.Clarke's Isolation and Identification of Drugs, London:The Pharmaceutical Press ( 1986).
18.
Blanke, R.V.Fundamentals of Clinical Chemistry, Philadelphia, PA: W. B. Saunders Comp. (1970).
19.
Levin, B.C. , J.L. Gurman, M. Paabo, L. Baier, L. Procell and H. Newball."Acute Inhalation Toxicity of Hydrogen Cyanide,"The Toxicologist, 6:59 ( 1986).
20.
Norris, J.C. , S.J. Moore and A.S. Hume."Synergistic Lethality Induced by the Combination of Carbon Monoxide and Cyanide,"Toxicology, 40:121-129 (1986).
21.
Thomas, W.C. and E.J. O'Flaherty."Cytochrome c Oxidase Activity in Tissues of Rats Exposed to Polyurethane Pyrolysis Fumes,"Toxicol. Appl. Pharmacol., 49:463-472 (1979).
22.
Purser, D.A. and W.D. Woolley."Biological Studies of Combustion Atmospheres,"J. of Fire Sciences, 1:118-144 (1983).
23.
Rodkey, F.L. and H.A. Collison."Effects of Oxygen and Carbon Dioxide on Carbon Monoxide Toxicity,"J. of Combustion Toxicol. , 6:208-212 (1979).
24.
Erecinska, M. and D.F. Wilson.Inhibitors of Mitochondrial Function , Oxford:Pergamon ( 1981).
25.
Kennah, H.E. , M.F. Stock and Y. Alarie."Toxicity of Thermal Decomposition Products from Composites,"J. of Fire Sciences , 5:3-16 (1987).
26.
Morikawa, T."Acrolein, Formaldehyde and Volatile Fatty Acids from Smoldering Combustion,"J. Fire Flammability, Comb. Toxicol., 3:135 (1976).
27.
Anderson, R.A. , A.A. Watson and W.A. Harland."Fire Deaths in the Glasgow Area: II. The Role of Carbon Monoxide,"Med. Sci. Law , 21:60-66 (1981)
Wetherell, H.R."The Occurrence of Cyanide in the Blood of Fire Victims,"J. of Forensic Sciences , 11:167-173 (1966).
30.
Anderson, R.A. and W.A. Harland."Fire Deaths in the Glasgow Area: III. The Role of Hydrogen Cyanide,"Med. Sci. Law , 22:35-72 (1982).
31.
Ballantyne, B."In Vitro Production of Cyanide in Normal Human Blood and the Influence of Thiocyanate and Storate Temperature,"Clin. Toxicol., 11:173-193 (1977).
32.
Esposito, F.M.Blood and Air Concentrations of Benzene, Carbon Monoxide, and Hydrogen Cyanide Following Inhalation of these Gases or Thermal Decomposition Products of Polymers Releasing these Toxicants, PhD dissertation, University of Pittsburgh (1987).
