To characterize the memory dysfunction of schizophrenic patients.
Method:
The components of the human memory system are described, and then a review of the various memory deficits identified among patients suffering from schizophrenia is presented. Finally, an overview of the latest developments in the comprehension of schizophrenia and a discussion on certain proposals advanced by various researchers in the field intended to shed light on the disorder is provided.
Results:
Schizophrenia appears to be an amalgamation of many different disorders. No single model for identifying the disorder has been able to encompass every aspect of schizophrenia.
Conclusion:
Future studies will need to consider new ways of selecting and grouping schizophrenic patients.
ShalliceTBurgesPWFrithCD. Can the neuropsychological case-study approach be applied to schizophrenia?Psychol Med1991;21:661–73.
2.
WidlocherDHardy-BayleMC. Cognition and control of action in psychopathology. European Bulletin of Cognitive Psychology1989;9:583–615.
3.
PlaceEJSGilmoreGC. Perceptual organization in schizophrenia. J Abnorm Psychol1980;136:384–95.
4.
ThomasJLaplanteLEverettJ.Schizophrénie et attention sélective. L'Encéphale1989;15:7–12.
5.
CoxMDLeventhalDB. A multivariate analysis and modification of a preattentive, perceptual dysfunction in schizophrenia. J Nerv Ment Dis1978;166:709–18.
6.
ParkSHolzmanPS. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry1992;49:975–82.
7.
DanionJ-M.Les troubles de la mémoire dans la schizophrénie. In: Mémoire explicite, mémoire implicite et pathologies psychiatriques. Paris: Masson éd; 1993. p 173–84.
8.
StipELussierIBabaïMDebruilleB.Cognitive decline in young drug-naive schizophrenia. Schizophr Res1995;15:135.
9.
FlemmingKGoldbergTEGoldJMWeinbergerDR. Verbal working memory dysfunction in schizophrenia—use of Brown-Peterson Paradigm. Psychiatry Res1995;56:155–61.
10.
SaykinARubenCRaquelE, and others. Neuropsychological function in schizophrenia: Selective impairment in memory and learning. Arch Gen Psychiatry1992;48:618–24.
11.
GoldbergTEWeinbergerDRPliskinNHBermanKBPoddMH. Recall memory deficit in schizophrenia: A possible manifestation of prefrontal dysfunction. Schizophr Res1989;2:251–7.
12.
HenikAPrielBUmanskyR.Attention and automaticity in semantic processing of schizophrenic patients. Neuropsychiatry, Neuropsychology and Behavioral Neurology1992;5:161–9.
13.
McKennaPJTamlynDLundCEMortimerAMHammondSBeddeleyAD. Amnesic syndrome in schizophrenia. Psychol Med1990;20:967–72.
14.
SchwartzBLDeutschLHCohenC.Memory for temporal order in schizophrenia. Biol Psychiatry1991;29:329–39.
15.
CalevA.Memory in schizophrenia. In: WellerM, editor. Internation perspectives in schizophrenia: Biological, social and epidemiological findings. London: John Libbey; 1990. p 29–41.
16.
Gras-VincendonADanionJ-MGrangeD, and others. Explicit memory, repetition, priming and cognitive skill learning in schizophrenia. Schizophr Res1994;13:117–26.
17.
StipELussierIBabaïMDebruilleB.Atteintes cognitives précoces dans la démence précoce: Résultats chez les jeunes schizophrènes non traités par les neuroleptiques. Médecine Sciences1995;11–39.
18.
StipELussierI.The effect of risperidone on cognition in patients with schizophrenia. Can J Psychiatry1996. In press.
19.
KennyJTMeltzerHY. Attention and higher cortical functions in schizophrenia. J Neuropsychiatry Clin Neurosci1991;3:269–75.
20.
KohSD. Remembering of verbal materials by schizophrenic young adults. In: SchwartzS, editor. Language and cognition in schizophrenia. New York: Wiley; 1978.
21.
TamlynDMcKennaPJMortimerAMLundCEHammondSBeddeleyAD. Memory impairment in schizophrenia: Its extent, affiliations and neuropsychological character. Psychol Med1992;12:564–71.
22.
ClareLMcKennaPJMortimerAHBaddelleyAD. Memory in schizophrenia: What is impaired and what is preserved. Neuropsychologia1993;31:1225–41.
23.
ChapinKMcCownJVannLKenneyIYoussefI.Activation and facilitation in the lexicon of schizophrenics. Schizophr Res1992:6:251–5.
24.
HenikANisimovEPrielB, and others. Effects of cognitive load on semantic priming in patients with schizophrenia. J Abnorm Psychol1995;104:576–84.
25.
SchmandBBrandNKuipersT.Procedural learning of cognitive and motor skills in psychotic patients. Schizophr Res1992;8:157–70.
26.
Saint-CyrJTaylorAELangAE. Procedural learning and neostriatal dysfunction in man. Brain1988;111:941–59.
27.
GoldbergTESaint-CyrJWeinbergerDR. Assessment of procedural learning and problem solving in schizophrenic patients by Tower of Hanoi type tasks. J Neuropsychiatry Clin Neurosci1990;2:165–73.
28.
BrozoskiTBrownRMRosvoldHEGoldman-RakicPS. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science1979;205:429–32.
29.
Goldman-RakicPS. The working memory. Scientific American1992;267(3):110–8.
30.
BermanK.F.ZeeRFWeinbergerDR. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia, II: Role of neuroleptic treatment, attention and mental effort. Arch Gen Psychiatry1986;43:126–35.
31.
RialleVStipE.La modélisation en psychiatrie: Des modèles symboliques aux modèles parallèles et distribués. J Psychiatry Neurosci1994;19:178–92.
32.
FrithCD. The cognitive neuropsychology of schizophrenia. Howe (UK): LEA; 1992.
33.
HeinrichsWRAwadGA. Neurocognitive subtypes of chronic schizophrenia. Schizophr Res1993;9:49–58.
