Early interstitial cystitis

Abstract

Interstitial cystitis can often be the cause of persistent sine materia irritative voiding synptoms. The Authors report their experience in diagnosis and therapy of this rare and invalidating pathology, showing typical endoscopic and histopathological features. Cystoscopic features, although defined non-typical, are very characteristic because of quick appearance of glomerulus, multiple petechial hemorrhages of the mucosa during bladder distension at also mild hydrostatic pressure. Histopathological features in interstitial cystitis, also if nonspecific, are very important, both to exclude neoplastic or specific inflammatory lesions, and for the exact inflammatory definition of the bladder wall. Mastocytosis in the bladder muscular layer (> 28/mmq) is typical of IC, but to consider lower concentrations is also important, together with remaining histological findings, in order to give exact therapy and follow-up to this disease that affects the quality of life.