Sage Journals: Discover world-class research

Abstract

Thrombus formation on biomaterial surfaces with microstructures is complex and not fully understood. We have studied the micro-secondary flow around microstructures that causes components of blood to adhere physically in a low Reynolds number region. The purpose of this study was to investigate the effect of micro-column size on the adhesion phenomena and show a quantitative relationship between the micro-secondary flow and physical adhesion phenomena, considering microstructures of various sizes. The flow simulation and quantitative assessment of adhesion rates around micro-columns was conducted using four sizes of micro-columns. This study also calculated the vectors of micro-secondary flow and average shear rate around a micro-column using a computational fluid dynamics analysis. The simulation showed the micro-secondary flow toward the bottom surface at upstream side and low shear rate distribution generated around a micro-column. Furthermore, physical adhesion tests were conducted using microbeads and a perfusion circuit to examine the size effect of the micro-columns on the physical adhesion. The results showed that the average adhesion rate around the micro-column increases with the associated size increase of the micro-column. Our results indicate that quantification of micro-secondary flow on a material surface with microstructures of several sizes and shapes (such as in a rough surface) is important for the evaluation of the adhesion phenomenon even though the surface roughness value on the material surface is small.

Keywords

Average shear rate three-dimensional micro-geometric structures net average adhesion rate physical adhesion phenomena size effect

Get full access to this article

View all access options for this article.

References

Zingg

Neumann

Strong

et al . Effect of surface roughness on platelet adhesion under static and under flow conditions. Can J Surg 1982; 25(1): 16–19.

Chepurov

Mertsalova

Dubovich

et al . Effect of roughness of polymer surfaces on thrombus formation. Biomed Eng 1977; 11(6): 312–315.

Imachi

. Surface modification in the artificial heart. J Surface Finishing Soc 1995; 46(10): 907–911.

Linneweber

Dohmen

Kertzscher

et al . The effect of surface roughness on activation of the coagulation system and platelet adhesion in rotary blood pumps. Artif Organs 2007; 31(5): 345–351.

Fujisawa

Poole-Warren

Woodard

et al . A novel textured surface for blood-contact. Biomaterials 1999; 20(10): 955–962.

Rose

Levin

et al . Artificial circulatory support with textured interior surfaces. A counterintuitive approach to minimizing thromboembolism. Circulation 1994; 90(52): 1187–1191.

Chen

Han

Jiang

. On improving blood compatibility: from bioinspired to synthetic design and fabrication of biointerfacial topography at micro/nano scale. Colloids Surf B Biointerfaces 2011; 85(1): 2–7.

Yamada

Nishinaka

Mizuno

et al . Neointima-inducing inflow cannula with titanium mesh for left ventricular assist device. J Artif Organs 2011; 14(4): 269–275.

Miyamoto

Nishinaka

Mizuno

et al . LVAD inflow cannula covered with a titanium mesh induces neointimal tissue with neovessels. Int J Artif Organs 2015; 38(6): 316–324.

10.

Shaoa

Zhoua

et al . Research on micro-structure and hemo-compatibility of the artificial heart valve surface. Appl Surface Sci 2009; 255(13–14): 6686–6690.

11.

Watanabe

Affeld

Schaller

et al . Investigation of human platelet adhesion under low shear conditions in a rotational flow chamber. J Biorheol 2011; 25(1): 64–70.

12.

Oota-Ishigaki

Masuzawa

Shibata

. Effect of flow around three-dimensional micro-geometric structures on adhesion phenomena. Life Support 2017; 29(2): 49–55.

Analysis of the effect of the size of three-dimensional micro-geometric structures on physical adhesion phenomena using microprint technique

Abstract

Keywords

Get full access to this article

References