Some of the highest rates of erectile dysfunction are seen in patients with renal failure, especially those on dialysis. The treatment of erectile dysfunction has been revolutionized in the last decade by the introduction of sildenafil. The literature on sildenafil in dialysis patients is here reviewed. Sildenafil seems to be both safe and effective in the treatment of sexual dysfunction in the dialysis population.
BraunwaldE.Cellular and molecular biology of cardiovascular disease. In: WilsonJ.D., BraunwaldE., IsselbacherK.J., PetersdorfR.G., MartinJ.B., FauciA.S., RootR.K., eds. Principles of internal medicine.New York: McGraw-Hill; 1991. p 835–1026.
2.
LueT.F.Erectile dysfunction. N Eng J Med2000; 342: 1802–13.
3.
FinkH.A., MacDonaldR., RutksI.R., NelsonD.B., WiltT.J.Sildenafil for male erectile dysfunction. A systematic review and meta-analysis. Arch Intern Med2002; 162: 1349–60.
4.
BellinghieriG., SantoroD., Lo FortiB., MallamaceA., Maria De SantoR., SavicaV.Erectile dysfunction in uremic dialysis patients: Diagnostic evaluation in the sildenafil era. Am J Kidney Dis2001; 38(suppl 1): S115–7.
5.
PickeringG., ShepherdA., PuddeyI., GlasserD., OrazemJ., ShermanN., ManciaG.Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents. Am J Hypertens2004; 17: 1135–42.
6.
MahonA., SidhuP., MuirG., MacdougallI.The efficacy of sildenafil treatment of erectile dysfunction in male peritoneal dialysis patients. Am J Kidney Dis2005; 45: 381–7.
7.
SeibelI., De FigueiredoC., TelokenC., MoraesJ.Efficacy of oral sildenafil in hemodialysis patients with erectile dysfunction. J Am Soc Nephrol2002; 13: 2770–5.
8.
TurkS., KaralezliG., TonbulH.Z.Erectile dysfunction and the effects of sildenafil treatment in patients on haemodialysis and continuous ambulatory peritoneal dialysis. Nephrol Dial Transplant2001; 16: 1818–22.
ChangC., HungC., ChianS., YangA.Acute renal failure in a young man, 9 days after a 5-h persisting erection following Viagra: is there a causal relationship?Nephrol Dial Transplant1999; 14: 2045–7 (Letter).
11.
GrossmanE.B., SwanS.K., MuirheadG.J., GaffneyM., ChungM., DeRiestalH., ChowD., RaijL.The pharmacokinetics and hemodynamics of sildenafil citrate in male hemodialysis patients. Kidney Int2004; 66: 367–74.
12.
MohamedE.A., MacDowallP., CowardR.A.Timing of sildenafil therapy in dialysis patients – lessons following an episode of hypotension. Nephrol Dial Transplant2000; 15: 926–7.
13.
BarrouB., CuzinB., MalavaudB., PetitJ., ParienteJ., BuchlerM., CormierL., BenoitG., CostaP.Early experience with sildenafil for the treatment of erectile dysfunction in renal transplant recipients. Nephrol Dial Transplant2003; 18: 411–7.
14.
PaulH.R., McLeishD., RaoT.K.S., FriedmanE.A.Initial experience with sildenafil for erectile dysfunction in maintenance dialysis patients. J Am Soc Nephrol1998; 9: 222 (Abstract).
15.
RosasS.E., WassersteinA., KobrinS., FeldmanH.I.Preliminary observations of sildenafil treatment for erectile dysfunction in dialysis patients. Am J Kidney Dis2001; 37: 134–7.
16.
ChenJ., MabjeeshN.J., GreensteinA., NaduA., MatkinH.Clinical efficacy of sildenafil in patients on chronic dialysis. J Urol2001; 165: 819–21.
17.
JuergensenP., BotevR., WuerthD., FinkelsteinS.H., SmithJ.D., FinkelsteinF.O.Erectile dysfunction in chronic peritoneal dialysis patients: Incidence and treatment with sildenafil. Perit Dial Int2001; 21: 355–9.
18.
SiegelR., GrossmanE.Timing of sildenafil therapy in dialysis patients. Nephrol Dial Transplant2001; 16: 1719–20.
19.
Prieto CastroR.M., Anglada CuradoF.J., Regueiro LopezJ.C., Leva VallejoM.E., Molina SanchezJ., Saceda LopezJ.L., Requena TapiaM.J.Treatment with sildenafil citrate in renal transplant patients with erectile dysfunction. BJU Int2001; 88: 241–3.
20.
RostaingL., Tran-VanT., AderJ.Increased glomerular filtration rate in kidney transplant recipients who take sildenafil. N Engl J Med2000; 342: 1679–80.
21.
ChristB., BrockmeierD., HauckE.W., Kamali-ErnstS.Investigation on interaction between tacrolimus and sildenafil in kidney transplanted patients with erectile dysfunction. Int J Clin Pharmacol Ther2004; 42: 149–56.
22.
GovierF., PotempaA.J., KaufmanJ., DenneJ., KovalenkoP., AhujaS.A multicenter, randomized, double blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction. Clin Ther2003; 25: 2709–23.
