Abstract
OBJECTIVE:
In 1957 Witebsky proposed the criteria for defining a disease as autoimmune. Subsequently, the original postulates of Witebsky and associates have been revised, and now it is accepted that three types of evidences are necessary to establish that a human disease is autoimmune in origin: 1) direct proof, such as transfer of the disease by either pathogenic autoantibody or auto reactive T cells; 2) indirect evidence based on reproduction of the autoimmune disease in experimental animals, and 3) circumstantial evidence arising from destructive clinical clues, such as lymphocyte infiltration of the affected organs, association with other autoimmune diseases, correlation with particular major histocompatibility complex genes, and benefit from immunosuppressive therapy. In 1908, Claude and Gourgerot, in their review on polyglandular insufficiencies, suggested a common pathogenesis for these diseases. In 1912, Hashimoto described a mononuclear leukocyte infiltration in some goitrous thyroid glands that was defined as “struma lymphomatosa”. In 1940, similar lesions within pancreatic islets of patients with type 1 diabetes mellitus (“insulitis”) were described by Von Mayenburg. In 1954, Bloodworth suggested, for the first time, that the accumulation of antibodies in the thyroid gland in patients with Schmidt’s syndrome may be related to reduced levels of adrenal cortex hormones these key observations heralded the rapid development of scientific interest and a continuous progress in studies on autoimmunity, including organ-specific autoimmune diseases.
Autoimmune diseases can be due, in genetically susceptible individuals, to release of sequestered antigens, virus-induced alterations of host membrane proteins, cross-reactivity between environmental agents and host antigens, T cell bypass, or alteration of lymphoid cells and immune regulatory cells. All these theories, however, fail to explain the cascade of autoimmune aggression toward multiple organs in one individual, as in APS. The gene responsible for this condition has been isolated, cloned, and defined as AIRE (autoimmune regulator) gene associated with Autoimmune polyglandular syndrome -APS type 1 (Addison’s disease AD, hyperparathyroidism, mucocutaneus candidacies and hepatitis).
APS type 2, also known as Schmidt’s syndrome is characterized by the presence of autoimmune AD in association with either autoimmune thyroid diseases and/or type 1 diabetes mellitus. AD is present in 100% of the patients, autoimmune thyroid diseases in 69-82%, and type 1 diabetes mellitus in 30-52% of the patients.
MATERIAL AND METHOD:
146 patients with chronic non specific symptoms were inspected by indirect Bi-digital O-ring Test according to Prof. Y.Omura. Endocrine glands were inspected covering with aluminum foil. Different drugs and slides were used as reference substances. For thyroid gland, to determinate hypothyroidism we used L-thyroxin (Thyvoral) and to determinate hyperthyroidism we used Propilthyouracil. Criterions to diagnose intolerant glucose were: 1. presence of infections of endocrine pancreas (CMV), 2. Acetylcholine 1 ng and less (most often 100 pg). 3. Deficiency of chromium. According to findings, infections were treated by selective drug uptake enhancement method (Y.Omura). Autoimmunity was treated by magnetic water made by MDK-Chips (Made by Salubris): Thyroid restore and Pancreas restore. MDK-Chips are specific magnets which emit different frequencies depending on its use. Different frequencies affect water by changing its structure for every frequency. Drinking such water achieves a specific balance of the immune and metabolic system, which helps defeat illness without any harmful effect, and creates balance in the body.
RESULTS:
From 146 patients 94 (64.38%) were female, 52 male (35.62%). Adrenal glands were affected in 74 patients (50.68%), Pancreas in 100 (68.49%), Thyroid in 78 (53.42%), Ovary (testis) in 123 (84.23%), pituitary in 54 (36.98%). Single endocrine glands were affected in 10 patients (12.98%), 2 in 19 patients (24.7%), 3 in 20 (25.97%), 4 in 17 (22.07%) and 5 n 11 (14.29%). Infections we found out were: aerobal, anaerobal bacteria and Candida (100%), Ascaris lumbricoides (93%), Chlamydia trachomatis (90,4%), Tuberculosis (63%), CMV (75%), EBV (64.8%), HPV 18 (34. 8%), HSV2 (33.6%), Borrelia burdgoferi (31.2%), HSV 1 (20%), Chlamydia pneumoniae (19.2%), HSV 7 (16%). Presence of Integrin as a sign of EMF radiations over some part of body (86.3%). Presence of heavy metal (83.56%). Allergy on heavy metal were in 19, 6%. OGTT in patients were positive in 95%. From 78 patients with thyroid gland infections, blood test showed Tag-antibodies and anti-TPO in 37 p. (47%) in different levels. After treatment by MDK Chip, antibodies decreased on normal level in 33 p. (89. 18%), AntiInsulin antibody, were in 2 Ip (27.27%) from 77p which did blood test. After treatment by MDK Chip: Pancreas restore, in 18 patients (85.7%) antibodies decrease in normal level for average one and half months. ANA were present in 15 p. After treatment by MDK Chip, ANA decreased in normal level in 13 p (86.66%).
CONCLUSION:
Importance of BDORT diagnosis is in diagnosis of sub clinical Polyendocrine autoimmune syndrome, before is possible to detect antibodies as a predictive factor of illness, and to treat cause as infective agent also to protect from environmental causes as EMFs radiation and different chemical pollutants. New device MDK Chip for treatment autoimmunity encourage that we can finally stopped diseases like APS.
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