The Imaging of Brain Death

A definition of irreversible coma. JAMA 1968; 205: 337–340.

Guidelines for the determination of death. JAMA 1981; 19: 2184–2186.

Diringer M. , Steiner T. , Angstwurn H. Diagnosis of brain death. In: Hacke W, ed. Neurocritical Care. Berlin: Springer-Verlag, 1994; 4: 219–234.

Gomes A. , Hallinan J. Intravenous digital subtraction angiography in the diagnosis of brain death. AJNR 1983; 4: 21–24.

Kricheff I.I. , Pinto R.S. , George A.E. , Braunstein P. , Korein J. Angiographic findings in brain death. Ann N Y Acad Sci 1978; 315: 168–83.

Vatne K.P.N. , Lundar T. Digital subtraction angiography (DSA) in the evaluation of brain death. A comparison of conventional cerebral angiography with intravenous and intraarterial DSA. Neuroradiology 1985; 27: 155–157.

Schwartz J.A. , Baxter J. , Brill D. , Burns J.R. Radionuclide cerebral imaging confirming brain death. JAMA 1983; 249: 246–7.

Schwartz J.A. , Baxter J. , Brill D.R. Diagnosis of brain death in children by radionuclide cerebral imaging. Pediatrics 1984; 73: 14–8.

Korein J. , Braunstein P. , Kricheff I. , Lieberman A. , Chase N. Radioisotopic bolus technique as a test to detect circulatory deficit associated with cerebral death. 142 studies on 80 patients demonstrating the bedside use of an innocuous IV procedure as an adjunct in the diagnosis of cerebral death. Circulation 1975; 51: 924–39.

Tan W.S. , Wilbur A.C. , Jafar J.J. , Spigos D.G. , Abejo R. Brian death: use of dynamic CT and intravenous digital subtraction angiography. AJNR 1987; 8: 123–5.

Korein J. , Braunstein P. , George J. , Wichter M. Brain death: I. Angiographic correlation with the radioisotope bolus technique for evaluation of critical deficit of cerebral blood flow. Ann Neurol 1977; 2: 195–205.

Rosenklint A. , Jorgensen P. Evaluation of angiographic methods in the diagnosis of brain death. Correlation with local and systemic arterial pressure and intracranial pressure. Neuroradiology 1974; 7: 215–219.

Bradac G. , Simon R. Angiography in brain death. J Neurorad 1974; 7: 25–28.

Bergquist E. , Bergstrom K. Angiography in cerebral death. Acta Radiol (Diagn) Stockh 1972; 12: 2833–288.

Heiskanen O. Cerebral circulatory arrest caused by acute increase of intracranial pressure. A clinical and roentgenological study of 25 cases. Acta Neurol Scand (Suppl) 1964; 7: 1–57.

Arnold H. , Kuhne D. , Rohr W. , Heller M. Contrast bolus technique with rapid CT scanning a reliable diagnostic tool for the determination of brain death. Neuroradiology 1981; 22: 129–132.

VanBunnen Y. , Delcour C. , Wery D. Intravenous digital subtraction angiography: a criterion of brain death. Ann Radiol 1989; 32: 279–281.

Jefferson N. Further aspects of angiographic brain death. Australas Radiol 1975; 19: 289–296.

Van-Velthoven V. , Calliauw L. Diagnosis of brain death. Transcranial Doppler sonography as an additional method. Acta Neurochir 1988; 95: 57–60.

Tsai S.H. , Cranford R.E. , Rockswold G.L. , Koehler S. Cerebral radionuclide angiography. Its application in the diagnosis of brain death. JAMA 1982; 248: 591–2.

Cowen R.J. Conventional radionuclide brain imaging in the era of transmission and emission tomography. Semin Nucl Med 1986; 16: 63–73.

Patel Y.P. , Gupta S.M. , Batson R. , Herrera N.E. Brain death: confirmation by radionuclide cerebral angiography. Clin Nucl Med 1988; 13: 438–42.

Goodman J.M. , Heck L.L. , Moore B.D. Confirmation of brain death with portable isotope angiography: a review of 204 consecutive cases. Neurosurgery 1985; 16: 492–7.

Nagle C.E. Use of immediate static scans in combination with radionuclide cerebral angiography as a confirmatory test in the diagnosis of brain death. Clin Nucl Med 1980; 5: 152–3.

Mishkin F. Determination of cerebral death by radionuclide angiography. Radiology 1975; 115: 135–137.

Goodman J.M. , Mishkin F.S. , Dyken M. Determination of brain death by isotope angiography. JAMA 1969; 209: 1869–72.

Goodman J.M. , Heck L.L. Confirmation of brain death at bedside by isotope angiography. JAMA 1977; 238: 996–8.

Mishkin F. Brain scanning in children. Semin Nucl Med 1972; 2: 328–42.

Mishkin F.S. Cerebral radionuclide angiography. Angiology 1977; 28: 261–75.

Mishkin F. Death and “brain death”. N Engl J Med 1978; 299: 1313–1314.

Brill D.R. , Schwartz J.A. , Baxter J.A. Variant flow patterns in radionuclide cerebral imaging performed for brain death. Clin Nucl Med 1985; 10: 346–52.

Ashwal S. , Smith A.J. , Torres F. , Loken M. , Chou S.N. Radionuclide bolus angiography: a technique for verification of brain death in infants and children. J Pediatr 1977; 91: 722–7.

Burkhalter J.L. , Patel B.R. Radiological seminar CCXXIV: Radionuclide cerebral angiography and brain death. J Miss State Med Assoc 1982; 23: 258–60.

Kuni C.C. , Rogge D.M. Radionuclide brain perfusion studies in suspected brain death. Clin Nucl Med 1986; 11: 551–5.

Holzman B.H. , Curless R.G. , Sfakianakis G.N. , Ajmone-Marsan C. , Montes J.E. Radionuclide cerebral perfusion scintigraphy in determination of brain death in children. Neurology 1983; 33: 1027–31.

Pearson J. , Korein J. , Harris J. , Wichter M. , Braunstein P. Brain death: II. Neuropathological correlation with the radioisotopic bolus technique for evaluation of critical deficit of cerebral blood flow. Ann Neurol 1977; 2: 206–210.

Riva A. , Gonzalez F. , Llamas-Elvira J. A diagnosis of brain death: Superiority of perfusion studies with Tc-99m HMPAO over conventional radionuclide cerebral angiography. Br J Radiol 1992; 65: 289–294.

Spieth M. , Ansari A. , Kawada T. , Siegel M. Comparison of DTPA and HMPAO for the evaluation of brain death. J Nucl Med 1991; 32: 1839.

Lee V.W. , Hauck R.M. , Morrison M.C. Scintigraphic evaluation of brain death: significance of sagittal sinus visualization. J Nucl Med 1987; 28: 1279–83.

Laurin N.R. , Driedger A.A. , Hurwitz G.A. Cerebral perfusion imaging with technetium-99m HM-PAO in brain death and severe central nervous system injury [see comments]. J Nucl Med 1989; 30: 1627–35.

Coker S.B. , Dellehay G.L. Radionuclide cerebral imaging for confirmation of brain death in children: the significance of dural sinus activity. Pediatr Neurol 1986; 2: 43–6.

Alvarez L.A. , Lipton R.B. , Hirschfeld A. , Salamon O. , Lantos G. Brain death determination by angiography in the setting of a skull defect. Arch Neurology 1988; 45: 225–7.

Hansen A.V. , Lavin P.J. , Moody E.B. , Sandler M.P. False-negative cerebral radionuclide flow study, in brain death, caused by a ventricular drain. Clin Nucl Med 1993; 18: 502–5.

de-la-Riva A. , Gonzalez F.M. , Llamas-Elvira J.M. Diagnosis of brain death: superiority of perfusion studies with 99Tcm-HMPAO over conventional radionuclide cerebral angiography. Br J Radiol 1992; 65: 289–94.

Galaske R.G. , Schober O. , Heyer R. 99mTc-HM-PAO and 1231-amphetamine cerebral scintigraphy: a new, non invasive method in determination of brain death in children. Eur J Nucl Med 1988; 14: 446–52.

Galaske R.G. , Schober O. , Heyer R. Determination of brain death in children with 1231-IMP and Tc-99m HMPAO. Psychiatry Res 1989; 29: 343–5.

Larar G.N. , Nagel J.S. Technetium-99m-HMPAO cerebral perfusion scintigraphy: considerations for timely brain death declaration [Comments]. J Nucl Med 1992; 33: 2209–11.

Wilson K. , Gordon L. , Selby JB Sr The diagnosis of brain death with Tc-99m HMPAO. Clin Nucl Med 1993; 18: 428–34.

Schlake H.P. , Bottger I.G. , Grotemeyer K.H. Determination of cerebral perfusion by means of planar brain scintigraphy and 99mTc-HMPAO in brain death, persistent vegetative state and severe coma. Intens Care Med 1992; 18: 76–81.

Yatim A. , Mercatello A. , Coronel B. 99mTc-HMPAO cerebral scintigraphy in the diagnosis of brain death. Transplant Proc 1991; 23: 2491.

Costa D.C. , Motteux I.M. , McCready A.C. Diagnosis of brain death with technetium 99m hexamethylpropylene amine oxime. Eur J Nucl Med 1991; 18: 503–6.

Reid R.H. , Gulenchyn K.Y. , Ballinger J.R. Clinical use of technetium-99m HM-PAO for determination of brain death. J Nucl Med 1989; 30: 1621–6.

Roine R.O. , Launes J. , Lindroth L. , Nikkinen P. 99mTc-hexamethylpropyleneamine oxime scans to confirm brain death (letter). Lancet 1986; 2: 1223–4.

Roine R.O. , Launes J. , Lindroth L. , Nikkinen P. Brain death and cerebral blood flow (letter). Lancet 1987; 1: 46–7.

Brandau W. , Schober O. , Knapp W.H. Determination of brain death with technetium-99m-HMPAO [Letter; Comment]. J Nucl Med 1990; 31: 2075–6.

Schober O. , Galaske R. , Heyer R. Determination of brain death with 1231-IMP and 99mTc-HM-PAO. Neurosurg Rev 1987; 10: 19–22.

Wieler H. , Marohl K. , Kaiser K.P. , Klawki P. , Frossler H. Tc-99m HMPAO cerebral scintigraphy. A reliable, noninvasive method for determination of brain death. Clin Nucl Med 1993; 18: 104–9.

Valle G. , Ciritella P. , Bonetti M.G. , Dicembrino F. , Perrone E. , Perna G.P. Considerations of brain death on a SPECT cerebral perfusion study. Clin Nucl Med 1993; 18: 953–4.

Lewis R. , Padayachee T. , Beasley M. , Keen H. Investigation of brain death with Doppler-shift ultrasound. J R Soc Med 1983; 76: 3308–310.

Feri M. , Ralli L. , Felici M. , Vanni D. , Capria V. Transcranial Doppler and brain death diagnosis. Crit Care Med 1994; 22: 1120–6.

Zurynski Y. , Dorsch N. , Pearson I. , Choong R. Transcranial Doppler ultrasound in brain death: experience in 140 patients. Neurological Research 1991; 13: 248–52.

Wallash T.M. , Reinecke M. Transcranial Doppler in brain death [Letter; Comment]. Neurology 1990; 40:.

Payen D.M. , Lamer C. , Pilorget A. Evaluation of pulsed Doppler common carotid blood flow as a noninvasive method for brain death diagnosis: a prospective study. Anesthesiology 1990; 72: 222–9.

Petty G.W. , Mohr J.P. , Pedley T.A. The role of transcranial Doppler in confirming brain death: sensitivity, specificity, and suggestions for performance and interpretation. Neurology 1990; 40: 300–3.

Dernbach P.D. Transcranial Doppler determination of brain death [Letter). Neurosurgery 1989; 25:.

Gawlowski J. , Hassler W. Is TC-Doppler sonography a useful method for the determination of brain death? Neurosurgical Review 1989; 1: 307–10.

Ries F. , Moskopp D. Value of the transcranial Doppler ultrasound technique (TCD) for the determination of brain death. Neurosurg Review 1989; 1: 302–6.

Harders A. Atraumatic estimation of blood flow arrest in the diagnosis of cerebral death with the transcranial Doppler investigation technique. Neurosurg Review 1989; 1: 298–301.

Kirkham F.J. , Neville B.G. , Gosling R.G. Diagnosis of brain death by transcranial Doppler sonography (Letter; Comment). Archives of Dis Childhood 1989; 64: 889–90.

Glasier C.M. , Siebert J.J. , Chadduck W.M. , Williamson S.L. , Leithiser R. Jr. Brain death in infants: evaluation with Doppler US. Radiology 1989; 172: 377–80.

Hassler W. , Steinmetz H. , Pirschel J. Transcranial Doppler study of intracranial circulatory arrest. J Neurosurg 1989; 71: 195–201.

Newell D.W. , Grady M.S. , Sirrota P. , Winn H.R. Evaluation of brain death using transcranial Doppler. Neurosurgery 1989; 24: 509–13.

Pilay P.K. , Wilberger J. Transcranial Doppler evaluation of brain death (Letter). Neurosurgery 1989; 25: 481–2.

Powers A.D. , Graeber M.C. , Smith R.R. Transcranial Doppler ultrasonography in the determination of brain death. Neurosurgery 1989; 24: 884–9.

Bode H. , Sauer M. , Pringsheim W. Diagnosis of brain death by transcranial Doppler sonography. Arch Dis Childhood 1988; 63: 1474–8.

Van V.V. , Calliauw L. Diagnosis of brain death. Transcranial Doppler sonography as an additional method. Acta Neurochirurg 1988; 95: 57–60.

Hassler W. , Steinmetz H. , Gawlowski J. Transcranial Doppler ultrasonography in raised intracranial pressure and in intracranial circulatory arrest. J Neurosurgery 1988; 68: 745–51.

Ahmann P.A. , Carrigan T.A. , Carlton D. , Wyly B. , Schwartz J.F. Brain death in children: characteristic common carotid arterial velocity patterns measured with pulsed Doppler ultrasound. J Pediatrics 1987; 110: 723–8.

Kirkham F.J. , Levin S.D. , Padayachee T.S. Transcranial pulsed Doppler ultrasound findings in brain stem death. J Neurol, Neurosurg & Psych 1987; 50: 1504–13.

Ropper A.H. , Kehne S.M. , Wechsler L. Transcranial Doppler in brain death. Neurology 1987; 37: 1733–5.

McMenamin J.B. , Volpe J.J. Doppler ultrasonography in the determination of neonatal brain death. Ann Neurology 1983; 14: 302–7.

Lewis R.R. , Padayachee T.S. , Beasley M.G. , Keen H. , Gosling R.G. Investigation of brain death with Doppler-shift ultrasound. 1 Roy Soc Med 1983; 76: 308–10.

Yoneda S. , Nishimoto A. , Nukada T. , Kuriyama Y. , Katsurada K. To-and-fro movement and external escape of carotid arterial blood in brain death cases. A Doppler ultrasonic study. Stroke 1974; 5: 707–13.

Rangel R. Computerized axial tomography in brain death. Stroke 1978; 9: 597–598.

Rappaport Z. , Brinker R. , Rovit R. Evaluation of brain death by contrast-enhanced computerized cranial tomography. Neurosurgery 1978; 2: 230–22.

Walker A.E. Ancillary studies in the diagnosis of brain death. Ann N Y Acad Sci 1978; 315: 228–40.

Thompson J.R. , Ashwal S. , Schneider S. Comparison of cerebral blood flow measurements by xenon computed tomography and dynamic brain scintigraphy in clinically brain dead children. Acta Radiol Suppl 1986; 369: 675–9.

Johnson D.W. , Stringer W.A. , Marks M.P. Stable xenon CT cerebral blood flow imaging: rationale for and rule in clinical decision making. Am J Neuroradiol 1991; 12: 201–13.

Pistoia F. , Johnson D.W. , Darby J.M. The role of xenon CT measurements of cerebral blood flow in the clinical determination of brain death. Am J Neuroradiol 1991; 12: 97–103.

Darby J. , Yonas H. , Gur D. , Latchaw R. Xenon-enhanced computed tomography in brain death. Arch Neurol 1987; 44: 551–554.

Ashwal S. , Schneider S. , Thompson J. Xenon computed tomography measuring cerebral blood flow in the determination of brain death in children. Ann Neurol 1989; 25: 539–546.

Jones K.M. , Barnes P.D. MR Diagnosis of brain death. Am J Neuroradiol 1992; 13: 65–6.

Aichner F. , Felber S. , Birbamer G. Magnetic resonance: a noninvasive approach to metabolism, circulation, and morphology in human brain death. Ann Neurology 1992; 32: 507–11.

Garde K. , Mortensen A.C. , Toft P.B. Phosphorous and proton spectroscopy in relation to near incarceration and incarceration in the human brain. Acta Radiol 1994; 35: 197–200.

Terk M.R. , Gober J.R. , DeGiorgio C. Brain death in the neonate: assessment with P-31 MR spectroscopy [Letter; Comment]. Radiology 1992; 182: 582–3.

Kato T. , Tokumaru A. , O'uchi T. Assessment of brain death in children by means of P-31 MR spectroscopy: preliminary note. Work in progress. Radiology 1991; 179: 95–9.

Momose T. , Nishikawa J. , Watanabe T. Clinical application of 18F-FDG-PET in patients with brain death. Kaku Igaku. Jap J Nuclear Med 1992; 29: 1139–42.