Two of 632 Fischer-344 rats in a food restriction study had spontaneous, bilateral, multicentric renal tubular cell carcinomas. Although there were 104 litters represented in this study, both rats that developed this rare neoplasm were from the same litter. The littermates, one male and one female, were in the food-restricted treatment groups (60% of ad libitum intake) and were 550 and 447 days old, respectively, at death. The probability that the two rare bilateral renal neoplasms occurred by a chance event in littermates is approximately 0.8%. The apparent familial predisposition for development of specific types of neoplasms emphasizes the importance of randomization of individuals into treatment groups and consideration of lineage for rare tumors.
BannaschPZenbauH:
Renal cell adenoma and carcinoma, rat. In:
Urinary System—Monographs on Pathology of Laboratory Animals,
ed. JonesTCMohrUHuntRD,
pp. 112–139.
Springer-Verlag,
Berlin, Germany,
1986.
2.
BenningtonJLBeckwithJB:
Tumors of the kidney, renal pelvis, and ureter. In:Atlas of Tumor Pathology,
2nd series, fascicle 12,
pp. 93–199.
Armed Forces Institute of Pathology,
Washington, DC,
1975.
3.
BoormanGAMcDonaldMRImotoSPersingR:
Renal lesions induced by ochratoxin A exposure in F344 rat.
Toxicol Pathol20:
236–245,
1992.
4.
CohenAJFrederickPLBergSMarchettoDJTsaiSJacobsSCBrownRS:
Hereditary renal-cell carcinoma associated with a chromosomal translocation.
N Engl J Med301:
592–595,
1979.
5.
CrissmanJWLongPHYanoBLEverittJI:
Spontaneous renal tubular tumors and atypical hyperplasia in two strains of rats on 90-day studies; comparison to hereditary renal carcinomas in the Eker rat.
Toxicol Pathol20:
641,
1992.
EkerRMossigeJ:
A dominant gene for renal adenomas in the rat.
Nature189:
858–859,
1961.
8.
EverittJIGoldsworthyTLWolfDCWalkerCL:
Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.
J Urol148:
1932–1936,
1992.
9.
GnarraJRToryKWengYSchmidtLWerMHLiHLatifFLiuSChenFDuhFMLubenskyIDaunDRFlorenceCPozzattiRWaltherMMBanderNHGrossmanHBBrauchHPomerSBrooksJDIsaacsWBLermanMIZbarBLinehanWM:
Mutatuions of the VHL tumor suppressor gene in renal carcinoma.
Nat Genet7:
85–90,
1994.
10.
HardGC:
High frequency, single-dose model of renal adenoma/carcinoma induction using dimethylnitrosamine in Crl:(W)BR rats.
Carcinogenesis5:
1047–1050,
1984.
11.
HardGC:
Tumors of the kidney, renal pelvis and ureter. In:
Pathology of Tumors in Laboratory Animals—Tumors of the Rat,
ed. TurusovVS, 2nd ed.,
pp. 301–344.
International Agency for Research on Cancer Scientific Publications,
Lyon, France,
1990.
12.
HasemanJKArnoldJEustisSL:
Tumor incidences in Fischer 344 rats: NTP historical data. In:
Pathology of the Fischer Rat,
ed. BoormanGAEustisSLElwellWRMontgomeryCAJrMackenzieWF,
pp. 555–564.
Academic Press,
San Diego, CA,
1990.
13.
HinoOKlein-SzantoAJPFreedJJTestaJRBrownDQVilenskyMYeungRSTartofKDKnudsonAG:
Spontaneous and radiation-induced renal tumors in the Dker rat model of dominantly inherited cancer.
Proc Natl Acad Sci USA90:
327–331,
1993.
14.
HinoOMitaniHNishizawaMKatsuyamaHKobayashiEHirayamaYA:
A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat.
Jpn J Cancer Res84:
1106–1108,
1993.
15.
KaibackHMcCallumWFKnovickaAJHollandMT:
Computer record keeping in a large rodent colony.
Lab Anim Sci27:
660–666,
1977.
16.
KuboYMitaniHHinoO:
Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.
Cancer Res54:
2633–2635,
1994.
17.
MontgomeryCSJrSeelyDJ:
Kidney. In:
Pathology of the Fischer Rat,
ed. BoormanGAEustisSLElwellWRMontgomeryCAJrMackenzieWF,
pp. 127–153.
Academic Press,
San Diego, CA,
1990.
18.
TsudaHKriegK:Neoplastic lesions in the kidney: In:Pathobiology of the Aging Rat,
ed. MohrUDungworthDLCapenCC,
pp. 227–240.
ILSI Press,
Washington, DC,
1992.
19.
WalkerCL:
Comparative molecular carcinogenesis: renal cell carcinoma and mesothelioma in rats and humans.
Toxicol Pathol21:
635–637,
1993.
20.
WittWMBrandCDAttwoodMSSoaveOA:
A nationally supported study on caloric restriction of rodents.
Lab Anim18:
37–43,
1989.
21.
YeungRSBuetowKHTestaJRKnudsonAG:
Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.
Proc Natl Acad Sci USA90:
8038–8042,
1993.
22.
YuBPMasoroEJMcMahanCA:
Nutritional influences on aging of Fischer 344 rats. I. Physical, metabolic, and longevity characteristics. J.
Gerontol40:
657–670,
1985.
