Clinical signs, pathologic changes and biochemical changes occurred in cattle with natural and experimental triaryl phosphate poisoning. Natural poisoning was caused by triaryl phosphates escaping from a gas pipeline compressor station. The clinical signs were posterior motor paralysis, dyspnea, diarrhea and agalactia. Experimental doses of 1/2-1 gm/kg body weight of these organophosphate compounds caused depression of Cholinesterase and axonal degeneration in the spinal cord.
References
1.
AhmedM.M.:
Synoptic morphology in the spinal cord of normal and tricresylphosphate (TCP) poisoned hen: an electron microscopic study.
Acta Neuropathol17:
302–309,
1971.
2.
AhmedM.M.GleesP.:
Ultrastructural changes in central nerve fibre of the hen.
Exp Neurol22:
695–701,
1968.
3.
AlbertiniA.:
Triaryl phosphate poisoning in Morocco: experiences and findings,
ed. AlbertiniGrossZinn;
League of Red Cross Societies,
Geneva,
1968.
4.
AldridgeW.M.BarnesJ.M.:
Further observations on the neurotoxicity of organophosphorous compounds.
Biochem Pharmacol15:
541–548,
1966.
5.
AldridgeW.M.ReinerE.:
Enzyme inhibitors as substrates;
1st ed.,
pp. 79–87,
North Holland,
1972.
6.
BarnesJ.M.:
Toxic substances and the nervous system.
Sci Basis Med Ann Rev183–201,
1969.
7.
BarnesJ.M.:
Toxic chemicals and peripheral neuropathy: experimental studies.
Proc R Soc Med62:
205–208,
1969.
8.
BarnettA.PeschelE.:
Potentiation of methamphetamine aggregate toxicity in mice by diethylthiocarbamate.
J Pharmacol20:
482,
1968.
9.
BeresfordW.A.GleesP.:
Degeneration in the long tracts of the cords of the chicken and cat after trioarthocresylphosphate poisoning.
Acta Neuropathol3:
108–118,
1963.
10.
CarpenterH.M.JendenD.J.ShulmanN.R.TuremanJ.R.:
Toxicology of a triaryl phosphate oil. I. Experimental toxicology.
Am Med Assoc Arch Ind Health20:62,
234–252,
1959.
11.
CavanaghJ.B.:
The toxic effects of tri-ortho-cresyl phosphate on the nervous system. An experimental study in hens.
J Neurol Neurosurg Psychiatry17:
163–172,
1954.
12.
CavanaghJ.B.:
Toxic substances and the nervous system.
Br Med Bull25:
268–273,
1969.
13.
CavanaghJ.B.DaviesD.R.HollandP.LancasterM.:
Comparison of the functional effects of dyflos, tri-o-cresyl phosphate and tri-p-ethylphenyl phosphate in chickens.
Br J Pharmacol17:
21–27,
1961.
14.
CavanaghJ.B.HollanP.:
Localization of cholinesterases in the chicken nervous system and the problem of the selective neurotoxicity of organophosphorous compounds.
Br J Pharmacol16:
218–230,
1961.
15.
CavanaghJ.B.PatangiaG.N.:
Changes in the central nervous system in the cat as the result of tri-o-cresyl phosphate poisoning.
Brain88:
165–180,
1965.
16.
ChaudhuriR.N.:
Paralytic diseases caused by consumption of flour contaminated with tricresyl phosphate.
Trans R Soc Trop Med Hyg58:
400–405,
1964.
17.
Chemical Abstracts: 70:1149n,
2584N, and
25842p,
1969.
18.
Chemical Geological Laboratories Ltd.:
Laboratory report E71-5360, Calgary, Alberta,
1971.
19.
DollahiteJ.W.PierceK.R.:
Neurologic disturbances due to triaryl phosphate toxicity.
Am J Vet Res30:
1461–1464,
1969.
20.
GentileG.GruarinR.:
Su un caso di auvelamento da T.O.C.P. in bovini.
Nuova Vet41:
116–125,
1965.
21.
EtoM.CasidaJ.TadakoE.:
Hydrolization and cyclization. Reactions involved in the metabolism of tri-o-cresyl phosphate.
Biochem Pharmacol11:
337–352,
1962.
22.
FriessS.L.JensenD.J.TuremanJ.R.:
Toxicology of a triaryl phosphate oil. II. A quantitative study of toxicity in different production batches.
Am Med Assoc Arch Ind Health20:
253–261,
1959.
23.
HaartmanA.B.VerhaartW.J.:
Cortical projections to brain stem and spinal cord in the goat by way of the pyramidal tract and the bundle of Bagley.
J Comp Neurol129:
189–202,
1967.
24.
HerscowitzA.NobuyoshiI.SchaumburgH.:
N-hexane neuropathy —a syndrome occurring as a result of industrial exposure.
New Engl J Med285:
82–85,
1971.
JagdholdH.:
Über schwere polyneuritis nach gebrauch von apiol.
Dtsch Med Wochenschr58:
623,
1932.
29.
JanzikH.H.GleesP.:
Chromatolysing spinal neurons in the chick following tricresylphosphate (TCP) intoxication.
Acta Neuropathol6:
303–306,
1966.
30.
JohnsonM.K.:
A phosphorylation site in brain and the delayed neurotoxic effect of some organophosphorous compounds.
Biochem J111:
487–495,
1969.
31.
JohnsonM.K.:
Delayed neurotoxic action of some organophosphorous compounds.
Br Med Bull25:
231–235,
1969.
32.
JohnsonM.K.:
The delayed neuropathy caused by some organophosphorous esters: mechanism and challenge.
CRC Crit Rev Toxicol3:
289–316,
1975.
33.
JohnsonM.K.BarnesJ.M.:
Age and the sensitivity of chicks to the delayed neurotoxic effects of some organophosphorous compounds.
Biochem Pharmacol19:
3045–3047,
1970.
34.
KopczynskiW.DolmierskiR.:
Psychic and sexual disturbances due to chronic poisoning with tri-o-cresyl phosphate.
Polish Med J8:
755–758,
1968.
35.
KruckenbergS.M.StrafussA.C.MarslandW.P.BlauchB.S.MarchR.T.VestiueherJ.G.WinterW.G.:
Posterior paresis in swine due to dermal absorption of the neurotoxic organophosphate tri-o-tolyl phosphate.
Am J Vet Res34:
403–404,
1973.
36.
MacDonaldK.R.:
Personal commun.,
1972.
37.
MassionJ.:
The mammalian red nucleus.
Physiol Rev47:
383–436,
1967.
38.
PickardM.A.WhelihanJ.A.WestlakeD.W.S.:
Utilization of triaryl phosphates by a mixed bacterial population.
Can J Microbiol21:
140–145,
1975.
PrineasJ.:
The pathogenesis of dying-back polyneuropathies. I. An ultrastructural study of experimental tri-ortho-cresyl phosphate intoxication in the cat.
J Neuropathol Exp Neurol28:
571–597,
1969.
41.
ShullL.R.CheekeP.P.:
Vitamin E-selenium and tri-o-cresyl phosphate interrelationships.
Proc West Sec, Am Soc Anim Sci23:
139–143,
1972.
42.
ShullL. R.CheekeP. P.selenium, TOCP relationships in erythrocyte hemolysisProc West Sec, Am Soc Anim Sci23:
148–151,
1972.
43.
SiegalJ.RudolphH.S.GetzkinA. J.JonesR.A.:
Effects on experimental animals of long term continuous inhalation of a triaryl phosphate hydraulic fluid.
Toxicol Appl Pharmacol7:
543–549,
1965.
44.
SilverA.:
Ataxia in hens poisoned by triparaethylphenyl phosphate.
Nature185:
247–248,
1961.
45.
SmithM.I.LillieM.D.:
The histopathology of tri-o-cresyl phosphate poisoning.
Arch Neurol Psychiat26:
976–992,
1931.
46.
SarokinM:
Orthocresyl phosphate neuropathy. Report of an outbreak in Fiji.
Med J Aust1:
506–508,
1969.
47.
WagemanR.GrahamB.LockhartW.L.:
Studies on chemical degradation and fish toxicity of a synthetic tri-aryl-phosphate lubrication oil,
IMOL S-140. Tech Rept No. 486,
Fisheries and Marine Service; Environment,
Canada,
1974.
