Chronic pulmonary irritation was induced in the chinchilla with talcum powder. Two effects on the pulmonary parenchyma were (1) exudative pneumonia, progressing quickly to predominantly proliferative pneumonia with formation of giant cell granulomas around talcum particles and (2) metaplasia of the alveolar epithelium in the areas adjacent to the granulomas. Early changes were hyperplasia of alveolar cells followed by their transformation into cuboidal cells to form a continuous lining in affected alveoli. In the final stage lesions approached an adenomatous appearance with tall columnar epithelium lining the affected alveoli. The experimental findings support the concept that chronic pulmonary irritation may be prerequisite to the development of adenomatous lesions in spontaneous pulmonary adenomatosis in the chinchilla.
References
1.
BellE. T.:
Hyperplasia of the pulmonary alveolar epithelium in disease.Amer. J. Path.19:
901–911(1943)
2.
DungalN.:
Experiments with Jaagsiekte.Amer. J. Path.22:
737–760(1946)
3.
FankhauserR.LuginbühlH.:
Chronisch-interstitielle Pneumonie mit Adenomatose bei Rindern im Kanton Uri. 1. Teil.Schweiz. Arch. Tierheilk.102:
47–58(1960)
4.
FischerW.:
Adenomatose und Krebsbildung bei chronischer Pneumonic des Meerschweinchens.Zbl. allg. Path.96:
555–562(1956)
5.
GeeverE. F.NeubuergerK. T.DavisC. L.:
The pulmonary alveolar lining under various pathologic conditions in man and animals.Amer. J. Path.19:
913–937(1943)
6.
GriciuteL.:
Experimental pulmonary adenomatosis in rabbits. In:
Lung Tumours in Animals.
Proc. of the Third Quadrennial Conf. on Cancer, University of Perugia.
Ed. by SeveriL.,
p. 789–796
(Division of Cancer Research Perugia,
Italy1966)
7.
HelmboldtC. F.JungherrE. L.Cuba CaparoA.:
Pulmonary adenomatosis in the chinchilla.Amer. J. vet. Res.19:
270–286(1958)
8.
HerbutP. A.:
Bronchiolar origin of “alveolar cell tumor” of the lung.Amer. J. Path.20:
911–929(1944)
9.
HerbutP. A.:
“Alveolar cell tumor” of the lung. Further evidence of its bronchiolar origin.Arch. Path.41:
175–184(1946)
10.
LaucheA.:
Trachea, Bronchien, Lungen und Pleura. In:
Jaffé: Anatomie und Pathologie der Spontanerkrankungen der kleinen Laboratoriumstiere
pp. 29–60
(Springer,
Berlin1931)
11.
LiebowA.:
Tumors of the lower respiratory tract. In:
Atlas of Tumor Pathology, Section V, Fasc. 17,
p. 189.
(Armed Forces Institute of Pathology,
Washington, D. C.1952)
12.
LüchtrathH.:
Experimenteller Beitrag zur Frage der Talkumlunge.
Beitr. Silikoseforsch.
Sonderband,
3:
69–76(1960)
13.
McFadyeanJ.:
Transformation of the alveolar epithelium in verminous pneumonia in the sheep.J. Comp. Path. Therap.33:
1–10(1920)
14.
OmarA. R.:
The characteristic cells of the lung and their reaction to injury.Vet. Bull.34:
371–382,
431–443(1964)
15.
RossI. S.:
Pulmonary epithelium and proliferative reactions in the lungs.Arch. Path.27:
478–496(1939)
16.
SchulzH.:
Some new observations on the submicroscopic pathology of the lung. Pulmonary adenomatosis and fat embolism.Lab. Invest.12:
616–627(1963)
17.
SeatonV. A.:
Pulmonary adenomatosis in cattle produced by nitrogen dioxide poisoning.North amer. Vet.38:
109–111(1957)
18.
SimonM. A.:
So-called pulmonary adenomatosis and “alveolar cell tumor”.Amer. J. Path.23:
413–427(1947)
SpruntD. H.DuckworthJ. K.FusteF. J.BellJ. S.MasseyL. C.:
The production of cancer of the lung by repeated irritation of the pulmonary epithelium. In:
Lung Tumours in Animals.
Proc. of the Third Quadrennial Conf. on Cancer, University of Perugia.
Ed. by SeveriL.,
p. 429–440
(Division of Cancer Research,
Perugia, Italy1966)
21.
StoianoffD.:
Über adenomatöse Wucherungen der Lungen bei Meerschweinchen.Zbl. allg. Path.100:
12–19(1959)
22.
SwanL. L.:
Pulmonary adenomatosis of man.Arch. Path.47:
517–544(1949)
23.
TaftE. B.NickersonD. A.:
Pulmonary mucous epithelial hyperplasia (pulmonary adenomatosis). A report of two cases.Amer. J. Path.20:
395–411(1944)
24.
TottenR. S.PierceG. B.Jr.:
Cortisone and atypical pulmonary “epithelial” hyperplasia. Further studies including electron microscopy, tissue culture, animal transplantation, and long term observations.Amer. J. Path.45:
977–990(1964)
25.
WoodD. A.PiersonP. H.:
Pulmonary alveolar adenomatosis in man. Is this the same disease as Jaagsiekte in sheep?Amer. Rev. Tubere.51:
205–224(1945)
