Abstract
A total of eight patients with chronic active HBsAg-positive hepatitis was treated with recombinant interferon-α2b for 12 months and serum aspartate aminotransferase, alanine aminotransferase, γ-globulin and prolyl hydroxylase concentrations were determined every 3 months. Liver biopsies after 12 months' treatment revealed a significant (P < 0.05) reduction in the histological activity score. After 6 months, alanine aminotransferase (P < 0.01) and aspartate aminotransferase (P < 0.05) concentrations fell significantly compared with baseline concentrations. Serum prolyl hydroxylase concentrations declined significantly (P < 0.05) after 15 months and remained depressed. It is concluded that interferon-α2b therapy reduced fibrogenetic activity in chronic active hepatitis B.
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