Forty-seven patients entered this comparison of frusemide–amiloride and cyclopenthiazide–potassium chloride in the treatment of congestive cardiac failure in general practice. Frusemide–amiloride was ‘very satisfactory’ in 92% of the patients compared to only 55% who took cyclopenthiazide–potassium chloride. Significantly more patients were free of paroxysmal nocturnal dyspnoea and orthopnoea after taking frusemide–amiloride.
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