In a double-blind study, three groups of patients with mild to moderate acne were treated for eight weeks with topical acne creams containing the antibacterials triclosan or triclosan plus propylene phenoxetol. The formula without antibacterials served as the control. Total-face lesion counts, evaluation of the overall degree of inflammation of the lesions, and patient self-assessment showed the added efficacy of the antibacterials when incorporated into the control.
Get full access to this article
View all access options for this article.
References
1.
BakerHWilkinsonD S (1972) Principles of treatment. In: Textbook of Dermatology. Vol. 2 (Ed. by RookAWilkinsonD SEblingF J G), pp. 2020. Blackwell Scientific Publications, Oxford & London.
2.
FuriaT ESchenkelA G (1968) 2,4,4‘-trichloro-2’-hydroxydiphenyl ether: A new broad spectrum bacteriostat. Soap and Chemical Specialities44, 47.
3.
KirtonVWilkinsonD S (1970) Benzoyl peroxide in acne. Practitioner204, 683.
4.
KligmanA MFultonJ EPlewigG (1969) Topical vitamin A acid in acne vulgaris. Archives of Dermatology99, 469.
5.
LanePWilliamsonD M (1969) Treatment of acne vulgaris with tetracycline hydrochloride: A double-blind trial with 51 patients. British Medical Journalii, 76.
6.
MaddoxD N (1976) Personal communication.
7.
MarplesR RDowningD TKligmanA M (1971) Control of free fatty acids in human surface lipids by Corynebacterium acnes. Journal of Investigative Dermatology56, 127.
8.
Nipa Laboratories Ltd (1976) Publication entitled: Some properties of the phenoxetol derivatives. Available from Nipa Laboratories Ltd., Treforest Industrial Estate, Pontypridd, Glamorgan, S Wales.
9.
PillsburyD MShelleyW BKligmanA M (1956) Dermatology. pp. 807 ff, W B Saunders, Philadelphia.
10.
PlewigGKligmanA M (1975) Acne Morphogenesis and Treatment, pp. 280 ff., Springer-Verlag, Berlin.
11.
PuhvelS MReisnerR MSakamotoM (1975) Analysis of human sebaceous gland homogenates after incubation with cutaneous bacteria: Thin layer chromatography. Journal of Investigative Dermatology64, 406.
12.
RayTKellumR E (1971) Acne vulgaris studies in pathogenesis: Free fatty acid irritancy in patients with and without acne. Journal of Investigative Dermatology57, 6.
13.
RobertsC D (1975) The role of bacteria in acne vulgaris. PhD thesis, University of Leeds.