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Abstract

Objectives

This study aimed to analyze the outcome and factors correlated with maintenance peritoneal dialysis (PD) to provide guidance for improving prognosis, and prolonging the catheterization and survival times of patients on PD with end-stage renal disease.

Methods

Clinical data of patients at The Third Xiangya Hospital of Central South University were retrospectively analyzed. We compared the survival and technique survival rates of patients, and analyzed relevant factors.

Results

A total of 510 cases of PD were included. Two hundred thirty-nine patients continued to receive PD treatment, 73 received kidney transplants, 72 transferred to hemodialysis, and 126 died. The main reasons of death were cardiovascular (27.00%) and cerebrovascular diseases (23.80%). The main reasons of transfer to HD were peritonitis and inadequate dialysis. The survival rates at 1, 2, 3, 5, and 7 years were 95.75%, 90.34%, 82.35%, 66.21%, and 54.32%, respectively. The technique survival rates at 1, 2, 3, 5, and 7 years were 93.22%, 86.76%, 77.91%, 63.16%, and 47.67%, respectively. Female sex and older age were protective factors that affected patients’ withdrawal from PD and survival time.

Conclusions

Death is the primary reason for withdrawal from PD. Female sex and older age affect patients’ withdrawal from PD and survival.

Keywords

End-stage renal disease peritoneal dialysis outcome risk factor older age survival hemodialysis

Introduction

End-stage renal disease (ESRD) is the end stage of chronic kidney disease (CKD) caused by various renal diseases. The number of patients with ESRD is significantly increasing in developed and developing countries.¹ By 2030, the projected number of people receiving renal replacement therapy (RRT) will reach 5.439 million. Approximately 2284 to 7083 million people will die prematurely because they do not have access to treatment, especially in low-income and middle-income countries in Asia, Africa, Latin America, and the Caribbean.² Currently, hemodialysis (HD) and peritoneal dialysis (PD) are the most conventional RRTs for ESRD. PD has become a common therapy because of its flexibility of home treatment, increased freedom, less hemodynamic instability issues, residual renal function preservation, lower hospitalization and intervention rates, and a higher quality of life compared with HD.^3–6 Despite numerous technical advances in PD therapy, rates of withdrawal from PD range from 19.80% to 54.80% depending on different populations and the study period.^7,8

A recent trial by Cooper et al. showed that compared with “late” or deferred dialysis, the prognosis of patients with PD did not improve survival or quality of life, or reduce the hospitalization rate.⁹ Furthermore, a national registry study reported an increase in the risk of death from patients on dialysis compared with the general population.¹⁰ Peritonitis is an important factor for withdrawal from PD therapy in Japan.¹¹ A national renal registry study showed that increasing age, female sex, and prior cerebrovascular disease were associated with withdrawal from dialysis.¹² However, there have been few reports about the causes of withdrawal from PD in China. Several studies have investigated risk factors associated with withdrawal from PD that include older people, hernia formation during PD therapy, and patients transferring from HD to PD.^13–15 Furthermore, the overall follow-up time was relatively short. Therefore, we conducted a retrospective study, which mainly focused on the long-term follow-up of Chinese patients, to identify the risk factors for withdrawal from treatment in patients on PD.

Patients and Methods

Patients

A total of 1260 patients underwent catheterization in the center for PD of the Third Xiangya Hospital of Central South University from 2002 to the end of 2016. The study protocol was approved by the Ethics Committee of Central South University Xiangya Third Hospital (No: 2018-S372). All patients provided written informed consent.

The inclusion criteria were as follows: (1) ≥18 years old; (2) continuous ambulatory peritoneal dialysis treatment for not less than 3 months; (3) patients had a clear time of catheter implantation and withdrawal; and (4) patients visited the hospital for reexamination at least every 6 months. The exclusion criteria were as follows: (1) lack of basic information; (2) acute renal failure or drug poisoning; (3) malignant tumor; (4) patients with severe underlying organ diseases, such as the heart and brain; (5) transfer to other centers; (6) patients did not adhere to the scheduled follow-up; and (7) loss to follow-up.

Study protocol

Basic clinical information of the patients on PD at the beginning of dialysis was collected, such as the patient’s name, sex, age of opening the tube, primary disease, complications, the date of catheterization, the condition and reason for the outcome, the date of withdrawal, the age of PD, and the occurrence of peritonitis.

Cardiovascular disease was defined as having a history of ischemic heart disease, angina attack, myocardial infarction, cerebral infarction or cerebral hemorrhage, coronary artery bypass/stenting, and transient ischemic attacks. The patient’s survival rate was defined as the start of PD treatment to death or to the end of the study (December 31, 2017). Death was recorded as an end-point event for the patient’s survival and was independent of the type of treatment that the patient received at the time. Except for death, any termination of peritoneal treatment (including a kidney transplant and PD transferred to HD) was used as censored data. The technical survival rate was defined as from the beginning of PD therapy to the failure of PD or to the end of the study (December 31, 2017). The retention and persistence of PD treatment as an end-point event was independent of whether the patient was alive at the time. The age of opening the tube was defined as the age at the time of catheterization. Insufficiency of dialysis was defined as failure to achieve an effect of dialysis.

Statistical analysis

Statistical analyses were conducted using SPSS, version 22.0 (IBM Corp., Armonk, NY, USA). Results are described as number and percentage for categorical data, and mean and standard deviation (SD) for approximately normally distributed continuous variables. The Student’s t-test was used to compare measurement data, while the χ² test was used to compare different rates. Kaplan–Meier analysis was used to calculate survival rates. Multivariate Cox regression analysis was used to analyze the risk factors of patients’ survival time, technique survival time, and withdrawal of PD. A P value <0.05 was considered statistically significant.

Results

Patients’ characteristics

A total of 510 patients on PD (308 [60.40%] men, 202 [39. 60%] women) were included in this study. The mean age of the patients was 48.35±13.92 years and the majority of patients were aged <65 years. The primary disease was mainly chronic glomerulonephritis, followed by hypertensive nephropathy and diabetic nephropathy. Peritonitis occurred in 166 (32.50%) patients (Table 1).

Table 1.

Basic characteristics of the patients.

Index	Values
Sex
Male	308 (60.40)
Female	202 (39.60)
Age (years)
<65	442 (86.70)
≥65	68 (13.30)
Primary disease
Chronic glomerulonephritis	321 (62.90)
Diabetic nephropathy	50 (9.80)
Hypertensive nephropathy	67 (13.10)
Polycystic renal	13 (2.50)
Obstructive nephropathy	21 (4.10)
Lupus nephritis	3 (0.60)
Gouty nephropathy	5 (1.00)
Anaphylactic purpura nephritis	3 (0.60)
Others	27 (5.30)
Peritonitis
No	344 (67.50)
Yes	166 (32.50)

Values are number (%).

Patients’ outcomes

To the end of the study, 239 (46.90%) patients continued to receive PD treatment, 73 (14.30%) received a kidney transplant, 72 (14.10%) were transferred to HD, and 126 (24.70%) died. Death and transfer to HD were the primary reasons for withdrawal from PD therapy. A total of 271 (53.10%) patients withdrew from PD. Of the patients who transferred to HD, the most common reason was for peritonitis, followed by inadequate dialysis, peritoneal rupture, and dialysis failure. The reasons of death were cardiovascular disease, cerebrovascular disease, dialysis failure, alimentary tract hemorrhage, infection, multiple organ failure, and others (Table 2).

Table 2.

Outcomes of all patients.

Outcome	Cases (n)	%
Transferred to HD	72	14.10
Peritonitis	50	69.40
Inadequate dialysis	11	15.20
Peritoneal rupture	4	5.50
Dialysis failure	2	3.00
Others	5	6.90
Death	126	24.70
Cardiovascular disease	34	27.00
Cerebrovascular disease	30	23.80
Dialysis failure	13	10.30
Alimentary tract hemorrhage	8	6.30
Infection	6	4.80
Multiple organ failure	5	4.00
Others	30	23.80
Peritoneal dialysis	239	46.90
Kidney transplant	73	14.30

HD: hemodialysis.

Multivariate Cox proportional hazards model for patients’ survival and technique survival

The survival rates at 1, 2, 3, 5, and 7 years were 95.75%, 90.34%, 82.35%, 66.21%, and 54.32%, respectively. Multivariate Cox regression analysis showed that older age (P < 0.001) and diabetic nephropathy (P = 0.05) were risk factors for the survival of patients (Table 3).

Table 3.

Multivariate Cox regression analysis of survival time in patients on PD.

Factors	P	HR	95% CI
Factors	P	HR	Lower limit	Upper limit
Sex
Male		1.00
Female	0.18	0.77	0.53	1.13
Age (years)
≤39		1.00
40–64	0.04	1.92	1.04	3.56
≥65	<0.001	4.01	2.04	7.87
Peritonitis rate	0.11	0.85	0.70	1.04
Primary disease
Others		1.00
Glomerulonephritis	0.70	1.12	0.63	2.01
Diabetic nephropathy	0.05	1.90	1.01	3.56
Hypertensive nephropathy	0.32	1.41	0.72	2.75

PD: peritoneal dialysis; HR: hazard ratio; CI: confidence interval.

The technique survival rates at 1, 2, 3, 5, and 7 years were 93.22%, 86.76%, 77.91%, 63.16%, 47.67%, respectively. Multivariate Cox regression analysis showed that female sex was a protective factor for the technique survival time (P = 0.02). The risk of technical failure of PD in women was lower than that in men (Table 4).

Table 4.

Multivariate Cox regression analysis of technique survival time in patients on PD.

Factors	P	HR	95% CI
Factors	P	HR	Lower limit	Upper limit
Sex
Male		1.00
Female	0.02	0.57	0.35	0.93
Age (years)
≤39		1.00
40–64	0.68	0.89	0.51	1.55
≥65	0.47	1.40	0.56	3.51
Peritonitis rate	0.08	1.18	0.98	1.43
Primary disease
Others		1.00
Glomerulonephritis	0.79	1.10	0.56	2.15
Diabetic nephropathy	0.41	0.63	0.21	1.88
Hypertensive nephropathy	0.52	1.39	0.52	3.76

PD: peritoneal dialysis; HR: hazard ratio; CI: confidence interval.

Multivariate Cox proportional hazards model for withdrawal from PD

Female sex was a protective factor that affected withdrawal of PD (P = 0.02). Multivariate Cox regression analysis showed that older age was a risk factor of patients withdrawing from PD (Table 5).

Table 5.

Multivariate Cox regression analysis of factors that affected withdrawal of PD.

Factors	P	HR	95% CI
Factors	P	HR	Lower limit	Upper limit
Sex
Male		1.00
Female	0.02	0.70	0.52	0.93
Age (years)
≤39		1.00
40–64	0.31	1.23	0.82	1.84
≥65	0.003	2.02	1.27	3.22
Diabetic nephropathy
No		1.00
Yes	0.367	1.10	0.74	1.60
Peritonitis
No		1.00
Yes	0.15	1.26	0.92	1.73

PD: peritoneal dialysis; HR: hazard ratio; CI: confidence interval.

Discussion

In this study, we retrospectively collected the clinical data of 510 cases of PD in a single center in China. We analyzed the general condition of the patients, the reasons for withdrawal from PD therapy, and the risk factors for survival of patients, to provide guidance for improving prognosis and prolonging the catheterization time and survival time of patients on PD with ESRD.

In this study, chronic glomerulonephritis was the primary disease of the 510 cases of PD, which is consistent with other studies.^16,17 We found that, in the present study, 271 (53.10%) patients withdrew from PD. Furthermore, death was the main reason for patients’ withdrawal from PD (24.70%), with most mortalities resulting from cardiovascular and cerebrovascular diseases. Luo et al. also reported that death was the main reason of early withdrawal from PD therapy.¹⁵ In many previous studies, the most common cause of death was cardiovascular disease.^18–20 However, other studies have shown that infection, rather than cardiovascular disease, is the main cause of death in patients of PD.^21–23 A reason for the difference between studies may be the duration of PD because a long time of PD therapy is more likely to cause infections. However, Japan’s national survey showed that the main reason for withdrawal from PD treatment was transfer to HD.²⁴ In this study, transfer to HD was the second leading cause of withdrawal from PD therapy. We also found that peritonitis was the leading reason for transfer to HD. Sakaci et al. also found that the main reason for patients transferring to HD was peritonitis.²⁵

In this study, the survival rates at 1, 2, 3, 5, and 7 years were 95.75%, 90.34%, 82.35%, 66.21%, and 54.32%, respectively. Another report showed that the survival rates of patients on PD were 89.0%, 76.0%, and 44.0% at 1, 2, and 5 years, respectively.²⁶ PD can prolong survival time for patients with ESRD, but the long-term survival rate is still not optimistic. In our study, the technique survival rates at 1, 2, 3, 5, and 7 years were 93.22%, 86.76%, 77.91%, 63.16%, and 47.67%, respectively. These results suggest that PD is a feasible and effective treatment for patients with ESRD, and it can help prolong the survival time of patients with ESRD. Kee et al. found that PD can be considered as a long-term RRT option, especially in non-diabetic, young patients with ESRD who are not overweight.²¹ Rigoni et al. also found that PD may be a viable option for large-scale dialysis treatment in the advanced CKD population.²⁷ These results were consistent with those of our study.

Multivariate Cox regression analysis was used to analyze the protective and risk factors for survival time, technique survival time, and withdrawal from PD. In the present study, older age and diabetic nephropathy were risk factors that affected survival time. Female sex was a protective factor that affected the technique survival time. A long-term survival study showed that age was a predictor of patients’ survival and technique survival.²⁸ Several studies have shown that older patients on PD have lower survival rates and technique survival rates than do younger patients.^29,30 Previous studies have shown that older age remains an important risk factor for patients withdrawing from PD.^15,31 The cause of this phenomenon may be that older patients tend to have more comorbidities, such as cardiovascular diseases, malnutrition, and hearing and visual impairments,³² which result in PD failure. In our study, female sex was a protective factor that affected patients’ withdrawal from PD. Furthermore, other studies showed that diabetes was a risk factor for patients who withdrew from PD.^33,34 He et al. found that peritoneal infection can increase the catheter removal rate and patients’ mortality, which can lead to withdrawal from PD and death of patients.³⁵ The Canadian Database reported that a higher peritonitis rate was present only among female patients with diabetes for the first time.³⁶ This may be related to patients’ local medical technology level.

Our study has limitations that should be considered in interpreting the results. The sample size of our study group was relatively small, and because it was conducted at a single center, it cannot represent the overall situation of patients on PD throughout China. Therefore, more large-scale, multicenter joint research needs to be carried out for confirmation of relevant results and conclusions.

Conclusion

Our findings suggest that chronic glomerulonephritis is the primary disease, and death and transfer to HD are the main reasons for withdrawal from PD therapy. Female sex is a protective factor affecting patients’ withdrawal and the PD technique survival time. Older age is a risk factor affecting patients’ withdrawal and PD survival time. Diabetic nephropathy is also a risk factor for PD survival time.

Abbreviations

ESRD, end-stage renal disease; RRT, renal replacement therapy; HD, hemodialysis; PD, peritoneal dialysis; CKD, chronic kidney disease.

Footnotes

Declaration of conflicting interest

The authors declare that there is no conflict of interest.

Funding

This work was supported by “Comparison of application of hemodialysis and peritoneal dialysis in ANCA associated vasculitis and renal failure” (no: C2017007).

References

Mousavi

Soleimani

Mousavi

MB.

Epidemiology of end-stage renal disease in Iran: a review article.

Saudi J Kidney Dis Transpl 2014; 25: 697–702.

Liyanage

Ninomiya

Jha

, et al. Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet 2015; 385: 1975–1982. DOI: 10.1016/S0140-6736(14)61601-9.

Chaudhary

Sangha

Khanna

Peritoneal dialysis first: rationale.

Clin J Am Soc Nephrol 2011; 6: 447–456.

Wang

Lai

KN.

The importance of residual renal function in dialysis patients.

Kidney Int 2006; 69: 1726–1732.

Oliver

Verrelli

Zacharias

, et al. Choosing peritoneal dialysis reduces the risk of invasive access interventions. Nephrol Dial Transplant 2012; 27: 810–816. DOI: 10.1093/ndt/gfr289.

Quinn

Ravani

Zhang

, et al. Impact of modality choice on rates of hospitalization in patients eligible for both peritoneal dialysis and hemodialysis. Perit Dial Int 2014; 34: 41–48. DOI: 10.3747/pdi.2012.00257.

Sanabria

Devia

Hernandez

, et al. Outcomes of a peritoneal dialysis program in remote communities within Colombia. Perit Dial Int 2015; 35: 52–61. DOI: 10.3747/pdi.2012.00301.

Descoeudres

Koller

Garzoni

, et al. Contribution of early failure to outcome on peritoneal dialysis. Perit Dial Int 2008; 28: 259–267.

Cooper

Branley

Bulfone

, et al. A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 2010; 363: 609–619. DOI: 10.1056/NEJMoa1000552.

10.

Findlay

Donaldson

Doyle

, et al. Factors influencing withdrawal from dialysis: a national registry study. Nephrol Dial Transpl 2016; 31: 2041–2048.

11.

Mizuno

Ito

Tanaka

, et al. Peritonitis is still an important factor for withdrawal from peritoneal dialysis therapy in the Tokai area of Japan. Clin Exp Nephrol 2011; 15: 727–737. DOI: 10.1007/s10157-011-0471-8.

12.

Findlay

Donaldson

Doyle

, et al. Factors influencing withdrawal from dialysis: a national registry study. Nephrol Dial Transplant 2016; 31: 2041–2048.

13.

Yang

Liu

Yang

, et al. The risk factors and the impact of hernia development on technique survival in peritoneal dialysis patients: a population-based cohort study. Perit Dial Int 2015; 35: 351–359. DOI: 10.3747/pdi.2013.00139.

14.

Bechade

Guittet

Evans

, et al. Early failure in patients starting peritoneal dialysis: a competing risks approach. Nephrol Dial Transplant 2014; 29: 2127–2135. DOI: 10.1093/ndt/gft055.

15.

Luo

Xia

Lin

, et al. Very early withdrawal from treatment in patients starting peritoneal dialysis. Ren Fail 2018; 40: 8–14. DOI: 10.1080/0886022X.2017.1419965.

16.

Sprangers

Kuypers

DR.

Recurrence of glomerulonephritis after renal transplantation.

Transplant Rev (Orlando) 2013; 27: 126–134. DOI: 10.1016/j.trre.2013.07.004.

17.

Singh

GR.

Glomerulonephritis and managing the risks of chronic renal disease.

Pediatr Clin North Am 2009; 56: 1363–1382. DOI: 10.1016/j.pcl.2009.09.014.

18.

Maiorca

Cancarini

Zubani

, et al. CAPD viability: a long-term comparison with hemodialysis. Perit Dial Int 1996; 16: 276–287.

19.

Lupo

Tarchini

Carcarini

, et al. Long-term outcome in continuous ambulatory peritoneal dialysis: a 10-year-survey by the Italian Cooperative Peritoneal Dialysis Study Group. Am J Kidney Dis 1994; 24: 826–837.

20.

Collins

Foley

Chavers

, et al. 'United States Renal Data System 2011 Annual Data Report: Atlas of chronic kidney disease & end-stage renal disease in the United States. Am J Kidney Dis 2012; 59: A7, e1–420. DOI: 10.1053/j.ajkd.2011.11.015.

21.

Kee

Park

Yoon

, et al. Characteristics and clinical outcomes of end-stage renal disease patients on peritoneal dialysis for over 15 Years: a single-center experience. Perit Dial Int 2017; 37: 535–541. DOI: 10.3747/pdi.2016.00227.

22.

Zhang

Ren

Xie

, et al. Causes of death in peritoneal dialysis patients with different kidney diseases and comorbidities: a retrospective clinical analysis in a Chinese center. Int Urol Nephrol 2014; 46: 1201–1207. DOI: 10.1007/s11255-013-0561-5.

23.

Choi

Jang

Park

, et al. Survival advantage of peritoneal dialysis relative to hemodialysis in the early period of incident dialysis patients: a nationwide prospective propensity-matched study in Korea. PLoS One 2013; 8: e84257. DOI: 10.1371/journal.pone.0084257.

24.

Kawaguchi

Ishizaki

Imada

, et al. Searching for the reasons for drop-out from peritoneal dialysis: a nationwide survey in Japan. Perit Dial Int 2003; 23(Suppl 2): S175–177.

25.

Sakaci

Ahbap

Koc

, et al. Clinical outcomes and mortality in elderly peritoneal dialysis patients. Clinics (Sao Paulo) 2015; 70: 363–368. DOI: 10.6061/clinics/2015(05)10.

26.

Nadeau-Fredette

Hawley

Pascoe

, et al. An incident cohort study comparing survival on home hemodialysis and peritoneal dialysis (Australia and New Zealand Dialysis and Transplantation Registry). Clin J Am Soc Nephrol 2015; 10: 1397–1407. DOI: 10.2215/cjn.00840115.

27.

Rigoni

Torri

Nollo

, et al. Survival and time-to-transplantation of peritoneal dialysis versus hemodialysis for end-stage renal disease patients: competing-risks regression model in a single Italian center experience. J Nephrol 2017; 30: 441–447. DOI: 10.1007/s40620-016-0366-6.

28.

De Sousa-Amorim

Bajo-Rubio

del Peso-Gilsanz

, et al. Thirty years in a peritoneal dialysis unit: long-term survival. Nefrologia 2013; 33: 546–551. DOI: 10.3265/Nefrologia.pre2013.Apr.11956.

29.

Ho-dac-Pannekeet

MM.

PD in the elderly–a challenge for the (pre)dialysis team.

Nephrol Dial Transplant 2006; 21(Suppl 2): ii60–62. DOI: 10.1093/ndt/gfl138.

30.

Buemi

Lacquaniti

Bolignano

, et al. Dialysis and the elderly: an underestimated problem. Kidney Blood Press Res 2008; 31: 330–336. DOI: 10.1159/000164277.

31.

Pulliam

Maddux

, et al. First-year outcomes of incident peritoneal dialysis patients in the United States. Am J Kidney Dis 2014; 64: 761–769. DOI: 10.1053/j.ajkd.2014.04.025.

32.

Joly

Anglicheau

Alberti

, et al. Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes. J Am Soc Nephrol 2003; 14: 1012–1021.

33.

Ghali

Bannister

Brown

, et al. Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. Perit Dial Int 2011; 31: 651–662. DOI: 10.3747/pdi.2010.00131.

34.

McDonald

Collins

Rumpsfeld

, et al. Obesity is a risk factor for peritonitis in the Australian and New Zealand peritoneal dialysis patient populations. Perit Dial Int 2004; 24: 340–346.

35.

Mao

, et al. Malnutrition-inflammation score predicts long-term mortality in Chinese PD patients. Clin Nephrol 2013; 79: 477–483.

36.

Nessim

Bargman

Austin

, et al. Predictors of peritonitis in patients on peritoneal dialysis: results of a large, prospective Canadian database. Clin J Am Soc Nephrol 2009; 4: 1195–1200. DOI: 10.2215/CJN.00910209.

Analysis of outcome and factors correlated with maintenance peritoneal dialysis

Abstract

Objectives

Methods

Results

Conclusions

Keywords

Introduction

Patients and Methods

Patients

Study protocol

Statistical analysis

Results

Patients’ characteristics

Patients’ outcomes

Multivariate Cox proportional hazards model for patients’ survival and technique survival

Multivariate Cox proportional hazards model for withdrawal from PD

Discussion

Conclusion

Abbreviations

Footnotes

Declaration of conflicting interest

Funding

References