Detection of lesions depends on the DARTEL template used in group comparisons with voxel-based morphometry

Abstract

Background

In many brain volumetry reports, data from both controls and patients have been used to create the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) templates for spatial normalization, whereas some studies used data from only the control group.

Purpose

To investigate the association between lesion detection and the processes used in creating DARTEL template in group comparisons with voxel-based morphometry.

Material and Methods

Three-dimensional T1-weighted MRI data of 31 healthy controls, 31 patients with Alzheimer’s disease, and 31 patients with idiopathic normal pressure hydrocephalus were obtained using a 3-T magnetic resonance scanner. Segmented gray matter images were then deformed into three types of DARTEL templates using the Statistical Parametric Mapping 12 software.

Results

Processes 1 (DARTEL template with all individuals) and 2 (DARTEL template with healthy controls) showed significant lesions, as observed in previous reports, whereas process 3 (DARTEL template with individuals divided into two groups) showed significantly larger lesions than those noted with processes 1 and 2.

Conclusion

The present study demonstrated that lesion detection depends on the processes used in the creation of the DARTEL template.

Keywords

Alzheimer’s disease DARTEL idiopathic normal pressure hydrocephalus normalization voxel-based morphometry

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