Abstract
Objective:
To investigate the feasibility, safety and efficacy of extended-release methylphenidate in enhancing processing speed, complex attentional functioning and everyday attentional behaviour after traumatic brain injury.
Design:
Seven week randomised, placebo-controlled, double-blind, parallel pilot study.
Setting:
Inpatient and outpatient Acquired Brain Injury Rehabilitation Program.
Participants:
Eleven individuals with reduced processing speed and/or attention deficits following complicated mild to severe traumatic brain injury.
Interventions:
Participants were allocated using a blocked randomisation schedule to receive daily extended-release methylphenidate (Ritalin® LA at a dose of 0.6 mg/kg) or placebo (lactose) in identical capsules.
Main outcomes:
Tests of processing speed and complex attention, and ratings of everyday attentional behaviour were completed at baseline, week 7 (on-drug), week 8 (off-drug) and 9 months follow-up. Vital signs and side effects were monitored from baseline to week 8.
Results:
Three percent (
Conclusion:
Methylphenidate was not associated with enhanced processing speed, attentional functioning or everyday attentional behaviour after traumatic brain injury. Alternative treatments for attention deficits after traumatic brain injury should be explored given the limited feasibility of methylphenidate in this population.
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Supplementary Material
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